APhA immunization certification
1. Main WBC of innate immunity
- process?: Macrophages
- engulf antigens, deliver to T-cells which release cytokines
2. WBC of cellular immunity: T-cells
- helper T: attach antigen, release cytokines, generate B-cell response
- cytotoxic T cells: destroy antigens
3. WBC of humoral immunity: B-cells
- mature to plasma cells (secrete antibodies)
- some remain as memory cells
4. Consideration for live attenuated vaccines: Must replicate to work
5. Consideration for inactivated vaccines: Antigen load stimulates
immune re- sponse
6. Polysaccharide vs conjugate polysaccharide vaccines?: Polysaccharide
- do not stimulate t-cells, short-lived immunity, no boost
Conjugate polysaccharide
- stimulate t-cells, there for memory/boost
7. Vaccination important during pregnancy: Tdap for *every* pregnancy
after 20 weeks gestation
(inactivated flu vaccine as well)
1/3
, 8. General consideration for immunosuppression and timeline of
vaccine administration: live vaccines: 4 weeks before
inactivated vaccines: 2 (4) weeks before
9. Shift vs drift
- new vaccine each year due to: Shift = large change in type
A flu drift = small change in type A/B flu
- *DRIFT*
10.Age recommendation for flu vaccination: over 6 mo, no
contraindications = GIVE
if 6mo-8 years and never had, 2 DOSES *FOUR WEEKS* APART
11.Egg allergy concern for: Flu vaccine - hives
*give anyway*
12. Timeline for PPSV23 and PCV13 for 65+
- vaccine naive
2/3
1. Main WBC of innate immunity
- process?: Macrophages
- engulf antigens, deliver to T-cells which release cytokines
2. WBC of cellular immunity: T-cells
- helper T: attach antigen, release cytokines, generate B-cell response
- cytotoxic T cells: destroy antigens
3. WBC of humoral immunity: B-cells
- mature to plasma cells (secrete antibodies)
- some remain as memory cells
4. Consideration for live attenuated vaccines: Must replicate to work
5. Consideration for inactivated vaccines: Antigen load stimulates
immune re- sponse
6. Polysaccharide vs conjugate polysaccharide vaccines?: Polysaccharide
- do not stimulate t-cells, short-lived immunity, no boost
Conjugate polysaccharide
- stimulate t-cells, there for memory/boost
7. Vaccination important during pregnancy: Tdap for *every* pregnancy
after 20 weeks gestation
(inactivated flu vaccine as well)
1/3
, 8. General consideration for immunosuppression and timeline of
vaccine administration: live vaccines: 4 weeks before
inactivated vaccines: 2 (4) weeks before
9. Shift vs drift
- new vaccine each year due to: Shift = large change in type
A flu drift = small change in type A/B flu
- *DRIFT*
10.Age recommendation for flu vaccination: over 6 mo, no
contraindications = GIVE
if 6mo-8 years and never had, 2 DOSES *FOUR WEEKS* APART
11.Egg allergy concern for: Flu vaccine - hives
*give anyway*
12. Timeline for PPSV23 and PCV13 for 65+
- vaccine naive
2/3
