BIOL 1018 EXAM QUESTIONS WITH ANSWERS
Molecular Biology Worksheet
The flow of information in a cell proceeds
A. from RNA to DNA to protein.
B. from protein to RNA to DNA.
C. from DNA to protein to RNA.
D. from RNA to protein to
DNA. E. from DNA to RNA to
protein
A segment of DNA has one strand with the following sequence of
bases:5`AGCGCATAGCAA3`. The complimentary strand of DNA would be
A. UCGCGUAUCGUU
B. TCGCGTATCGTT
C. GAUAUGCGAUGG
D. CTATACGCTACC
E. AGCGCATAGCAA
Both DNA and RNA
A. are single stranded
B. contain the same four nitrogenous bases
C. are polymers of amino acids
D. have the same five carbon sugars
E. contain phosphate groups
How does the structure of DNA provide a framework for replication?
A. Each polynucleotide strand is a complementary copy of the other.
B. Each polynucleotide strand is an exact copy of the other.
C. At no time do the two polynucleotide strands separate from each other.
D. The DNA is lumpy in some areas in which two purines are paired.
E. none of these choices are true
The leading strand in DNA synthesis is one continuously forming strand of DNA
while the lagging strand is a series of Okazaki fragments
A. True
B. False
DNA replication along the 3' --> 5' template strand
,BIOL 1018 EXAM QUESTIONS WITH ANSWERS
Molecular Biology Worksheet
A. is continuous. B. is discontinuous.
C. cannot occur. D. forms a lagging strand.
E. must loop the DNA
Prokaryote DNA synthesis has many replication bubbles
A. True
B. False
Use the following information to answer the question;
I. Uracil bonds with adenine.
II. Complementary bonding between codon
and anticodon.
III. DNA unzips.
IV. mRNA joins with ribosome.
The correct order of the above during protein synthesis is;
A. I, II, IV, III
B. I, III, II, IV
C. III, I, IV, II
D. III, II, I, IV
It has been established that, in many cells, ribosomes occur in chains along
messenger RNA molecules. What is the advantage of this arrangement when
compared with a situation in which ribosomes occur singly?
A. A greater variety of polypeptides can be produced.
B. Fewer transfer RNA molecules are used in protein synthesis
C. Larger polypeptide chains can be produced.
D. Polypeptides can be produced more
rapidly.
E. The probability of gene mutation occurring is lower.
Attributes of the genetic code include all of the following EXCEPT:
A. Each codon consists of 3 nucleotides.
B. Each codon specifies more than one amino acid.
C. Codons are non-overlapping.
D. Most amino acids are coded for by more than one codon.
E. The code is essentially universal.
The mRNA codons of amino acids in a sequence of part of a polypeptide chain are
shown below. 5’ UGU-GAU-CAC-UAG-GAU-AAG-CAC3’. Which DNA base
sequence could provide the code for this section of polypeptide?
A. 3'ACA-CTA-GTG-ATC-CTA-TTC-GTG 5'
B. 3' ACA-CTA-GTG-ATG-CTA-AAC-GTG 5'
C. 3'ACA-CTT-GTG-ATG-CTA-TTC-GTG 5'
D. 3' ACA-CUA-GUG-AUG-CUA-UUC-GUG 5'
E. 3'CAC-ATC-UTU-CTU-ATC-TTA-UTU 5'
, BIOL 1018 EXAM QUESTIONS WITH ANSWERS
Molecular Biology Worksheet
The natural role of restriction
endonucleases is to
A. allow the in vitro construction of recombinant DNA molecules
B. methylate host DNA
C. remove RNA primer during DNA synthesis
D. cleave foreign DNA molecules that enter the cell
A function of transfer RNA (tRNA) is to;
A. stay in the nucleus and be copied by DNA.
B. carry amino acids to the growing polypeptide chain.
C. copy DNA and carry the information to the ribosome.
D. read the codons and provide the site for protein synthesis.
If the code for an amino acid is AGC on the DNA molecule, the anticodon on the
tRNA would be
A. AGC
B. TGC
C. UCG
D. UGC
The DNA code for glutamic acid is CTC or CTT. The code for valine is CAA or
CAT. In sickle cell haemoglobin, valine is present instead of glutamic acid.
Assuming a single base pair substitution has occurred, what is the mRNA code in the
affected mutant?
A. CUU
B. GAA
C. GAG
D. GUA
E. GUU
A pharmaceutical company is studying a new antibiotic that inhibits bacterial protein
synthesis. When the antibiotic is added to an in vitro (test tube) protein synthesis
system that is translating the mRNA sequence AUGUUUUUUUAG, the only
product formed is the dipeptide fMet-Phe. What step in protein synthesis is MOST
LIKELY inhibited by the antibiotic?
A. Initiation of translation.
B. Binding of charged tRNA to the ribosomal A site.
C. Peptidyl transferase
activity. D. Ribosomal
translocation.
E. Termination of translation.
If the transcription of the mRNA were to occur in a human cell, which of
the following enzymes would be required?
A. RNA polymerase II
B. DNA polymerase α
C. RNA polymerase I
D. DNA ligase
Molecular Biology Worksheet
The flow of information in a cell proceeds
A. from RNA to DNA to protein.
B. from protein to RNA to DNA.
C. from DNA to protein to RNA.
D. from RNA to protein to
DNA. E. from DNA to RNA to
protein
A segment of DNA has one strand with the following sequence of
bases:5`AGCGCATAGCAA3`. The complimentary strand of DNA would be
A. UCGCGUAUCGUU
B. TCGCGTATCGTT
C. GAUAUGCGAUGG
D. CTATACGCTACC
E. AGCGCATAGCAA
Both DNA and RNA
A. are single stranded
B. contain the same four nitrogenous bases
C. are polymers of amino acids
D. have the same five carbon sugars
E. contain phosphate groups
How does the structure of DNA provide a framework for replication?
A. Each polynucleotide strand is a complementary copy of the other.
B. Each polynucleotide strand is an exact copy of the other.
C. At no time do the two polynucleotide strands separate from each other.
D. The DNA is lumpy in some areas in which two purines are paired.
E. none of these choices are true
The leading strand in DNA synthesis is one continuously forming strand of DNA
while the lagging strand is a series of Okazaki fragments
A. True
B. False
DNA replication along the 3' --> 5' template strand
,BIOL 1018 EXAM QUESTIONS WITH ANSWERS
Molecular Biology Worksheet
A. is continuous. B. is discontinuous.
C. cannot occur. D. forms a lagging strand.
E. must loop the DNA
Prokaryote DNA synthesis has many replication bubbles
A. True
B. False
Use the following information to answer the question;
I. Uracil bonds with adenine.
II. Complementary bonding between codon
and anticodon.
III. DNA unzips.
IV. mRNA joins with ribosome.
The correct order of the above during protein synthesis is;
A. I, II, IV, III
B. I, III, II, IV
C. III, I, IV, II
D. III, II, I, IV
It has been established that, in many cells, ribosomes occur in chains along
messenger RNA molecules. What is the advantage of this arrangement when
compared with a situation in which ribosomes occur singly?
A. A greater variety of polypeptides can be produced.
B. Fewer transfer RNA molecules are used in protein synthesis
C. Larger polypeptide chains can be produced.
D. Polypeptides can be produced more
rapidly.
E. The probability of gene mutation occurring is lower.
Attributes of the genetic code include all of the following EXCEPT:
A. Each codon consists of 3 nucleotides.
B. Each codon specifies more than one amino acid.
C. Codons are non-overlapping.
D. Most amino acids are coded for by more than one codon.
E. The code is essentially universal.
The mRNA codons of amino acids in a sequence of part of a polypeptide chain are
shown below. 5’ UGU-GAU-CAC-UAG-GAU-AAG-CAC3’. Which DNA base
sequence could provide the code for this section of polypeptide?
A. 3'ACA-CTA-GTG-ATC-CTA-TTC-GTG 5'
B. 3' ACA-CTA-GTG-ATG-CTA-AAC-GTG 5'
C. 3'ACA-CTT-GTG-ATG-CTA-TTC-GTG 5'
D. 3' ACA-CUA-GUG-AUG-CUA-UUC-GUG 5'
E. 3'CAC-ATC-UTU-CTU-ATC-TTA-UTU 5'
, BIOL 1018 EXAM QUESTIONS WITH ANSWERS
Molecular Biology Worksheet
The natural role of restriction
endonucleases is to
A. allow the in vitro construction of recombinant DNA molecules
B. methylate host DNA
C. remove RNA primer during DNA synthesis
D. cleave foreign DNA molecules that enter the cell
A function of transfer RNA (tRNA) is to;
A. stay in the nucleus and be copied by DNA.
B. carry amino acids to the growing polypeptide chain.
C. copy DNA and carry the information to the ribosome.
D. read the codons and provide the site for protein synthesis.
If the code for an amino acid is AGC on the DNA molecule, the anticodon on the
tRNA would be
A. AGC
B. TGC
C. UCG
D. UGC
The DNA code for glutamic acid is CTC or CTT. The code for valine is CAA or
CAT. In sickle cell haemoglobin, valine is present instead of glutamic acid.
Assuming a single base pair substitution has occurred, what is the mRNA code in the
affected mutant?
A. CUU
B. GAA
C. GAG
D. GUA
E. GUU
A pharmaceutical company is studying a new antibiotic that inhibits bacterial protein
synthesis. When the antibiotic is added to an in vitro (test tube) protein synthesis
system that is translating the mRNA sequence AUGUUUUUUUAG, the only
product formed is the dipeptide fMet-Phe. What step in protein synthesis is MOST
LIKELY inhibited by the antibiotic?
A. Initiation of translation.
B. Binding of charged tRNA to the ribosomal A site.
C. Peptidyl transferase
activity. D. Ribosomal
translocation.
E. Termination of translation.
If the transcription of the mRNA were to occur in a human cell, which of
the following enzymes would be required?
A. RNA polymerase II
B. DNA polymerase α
C. RNA polymerase I
D. DNA ligase
