PHARMACOLOGY - GI DRUGS 2023

PHARMACOLOGY - GI DRUGS 2023 Pantoprazole PPI with the least drug-drug interactions Proximal small intestine/duodenum Site of absorption of Proton pump inhibitors Cimetidine H2 blocker with CYP450 inhibition Forms protective coating on ulcerated tissue MOA of Bismuth subsalicylate Bulk-forming laxative MOA of Psyllium Blocking D2 receptors Metoclopramide and Domperidone act as prokinetic agents by Senna (anthraquinone-containing laxatives) Melanosis coli may occur as a result of taking Stimulant (directly stimulates enteric nervous system) Bisacodyl is what type of laxative Ursodeoxycholic acid Drug that may be used in the dissolution of small cholesterol gallstones Vitamin B12 deficiency, pneumonia, small benign gastric fundic-gland polyps Side effects with long term use of PPIs Metoclopramide Increase motility and resting tone of GIT for gastroparesis Parkinsonian features, Tardive dyskinesia, Galactorrhea, Akathisia Metoclopramide adverse effects Hyoscine Blocks muscarinic receptors for treatment of nausea and vomiting Bloody, mucoid stools, Young children, Acute ulcerative colitis Loperamide contraindications Finasteride Other drug that may be given to a patient with alopecia already given Minoxidil · Promotes satiety via hypothalamic receptor · Slows down gastric emptying time · Inhibits inappropriate secretion of glucagon Effects of Pramlintide · Steroids · Surgery · Immunomodulators Management of Crohn's disease Terlipressin Drug effective in bleeding esophageal varices Calcium channel blockers Antihypertensive contraindicated in patients with bleeding esophageal varices Diphenoxylate Centrally acting acting anti-diarrheal agent Osteoporosis and bone fracture, Hypomagnesemia, Eradicate H. pylori Complications of long-term use of Omeprazole Amylase, Lipase, Proteases Components of Creon 250