Hematology 2023
Anki:
https://docs.google.com/document/d/e/2PACX-1vSk6sRxgSre6n2r1jaH
f2Dn0KIYBfAQgeYeu_kbjySlCpZEoiN11PlwRFm8nSUfgfsgF7gjcILgfrC
E/pub
● Macrophages are found in tissues and are the product of one of the cell lineages
in the bone marrow. What is this cell lineage? #3
● A. Monocytic
● B. B-lymphocytic
● C. Granulocytic
● D. T-lymphocytic
● E. Megakaryocytic
○ A. Monocytic
● Which of the findings IS NOT FOUND in Disseminated Intravascular Coagulation
Syndrome in sepsis: #1
● A. Thrombocytopenia
● B. Reduced activity of Antithrombin III
● C. Short reptilase time
● D. Increased fibrin-degradation products
● E. Low fibrinogen
○ C. Short reptilase time
● Changes in which factors affects activated partial thromboplastin time (aPTT): #1
● A. Plasma + phospholipids + calcium
● B. Plasma + thromboplastin + calcium
● C. Plasma + phospholipids + thromboplastin
● D. Plasma + plasmin + calcium
● E. None of the above
○ A. Plasma + phospholipids + calcium
● The so-called "B symptoms" are described in a group of malignant haematological
diseases and is due to the secretion of pathological cytokines. It includes fever,
weight loss, abundant night sweats and persistent itching. In which of the
following diseases these symptoms determine the magnitude of its activity #1
● A. Chronic leukemias
● B. Hodgkin's Disease
● C. Myeloma
● D. Gaucher's Disease
● E. Acute leukemias
, ○ B. Hodgkin's Disease
● B cell lymphomas are characterized by the following cell markers and a
combination of monoclonal antibodies that are used for immunohistochemical
diagnosis: #1
● A. CD3, CD5, CD7
● B. CD10, CD20, CD23
● C. CD11, Cyclin D1, vimentin
● D. CD13, CD33, CD14
● E. None of the listed combinations
○ B. CD10, CD20, CD23
● What are the primary (central) lymphoid organs: #1
● A. Lymph nodes
● B. Liver, spleen, thymus
● C. Thymus, bone marrow
● D. Lymph nodes, spleen
● D. Spleen, liver
○ C. Thymus, bone marrow
● What is typical for immunoglobulin G (IgG): #1
● A. It is the most common - 80% of all immunoglobulin classes in serum
● B. It is the main immunoglobulin in mucous secretions
● C. It is involved in the late hypersensitivity reaction
● D. It is produced first in the immune response to an antigen
● E. All of the above are true
○ A. It is the most common - 80% of all immunoglobulin classes in serum
● In which cases are we talking about thalassemia intermedia: #1
● A. With a hemoglobin level between 70 and 100 g/l
● B. For heterozygous or homozygous forms
● C. In presence of microcytes and hypochromia
● D. The levels of HbA2 and HbF are increased
● E. All of the above
○ E. All of the above
● Which of the diseases listed below may manifest with ankylosis of the large joints
as a Complication: #1
● A. Thalassemia
● B. Down Syndrome
● C. Hemophilia
● D. Acute leukemia
● E. None of these
○ C. Hemophilia
,● A 28 years-old patient noticed bruises a week ago. He suffered from fatigue as
well. From the CBC: Hb 100 g/L; Leucocytes 1,3 G/L; Platelets 18 G/L. The blood
smear revealed granulated blast cells. The cytogenetical analysis showed t(15;17).
What is your diagnosis: #1
● A. Acute lymphoblastic leukemia
● B. Infectious mononucleosis
● C. Immune thrombocytopenia
● D. Leukemoid reaction
● E. Acute promyelocytic leukemia
○ E. Acute promyelocytic leukemia
● Complete remission achievement is the goal of treatment of acute leukemia.
Which of the parameters confirms complete remission: #1
● A. Blast cells in bone marrow <5%
● B. No organ infiltration signs
● C. Hemoglobin >100 g/L
● D. Platelets >100 G/L
● E. all of the above
○ E. all of the above
● What is the goal of the induction therapy in the treatment of AML: #2
● A. Normalizing the hemoglobin
● B. Prolongation of the life span
● C. Remission achievement
● D. Decreasing the blast percentage in bone marrow
● E. Overcome the hemorrhagic diathesis
○ C. Remission achievement
● What treatment is recommended for refractory myeloma: #1
● A. Experimental targeted therapy
● B. Treatment with Alkeran + Prednisolone
● C. Monoclonal Antibody - MabТhera
● D. Polychemotherapy with cytostatics from different pharmacological groups
● E. Autologous stem cell transplantation
○ A. Experimental targeted therapy
, ● The picture shows: #1
● A. Normal erythrocytes
● B. Megalocytes
● C. Anulocytes
● D. Rouleaux formations
● E. Red cell agglutination
○ D. Rouleaux formations
● In which disease is monoclonal paraprotein type IgA proven? #1
● A. Follicular lymphoma
● B. Autoimmune haemolytic anemia
● C. Chronic lymphocytic leukemia
● D. Multiple myeloma
● E. Chronic lymphocytic leukemia
○ D. Multiple myeloma
● Extreme splenomegaly of more than 1 kilogram weight is commonly related to: #1
● A. Infectious mononucleosis
● B. Primary myelofibrosis
● C. Sepsis
● D. Chronic right heart failure
● E. Chronic lymphocytic leukemia
○ B. Primary myelofibrosis
● Woman, 57y, complains of discomfort below the left rib cage which turns into
pain. Splenomegaly (+ 4cm) is revealed. From the CBC: hemoglobin 121 g/L,
leukocytes 56 G/L and platelets 358 G/L. The blood smear below is related most
likely to: #1
Anki:
https://docs.google.com/document/d/e/2PACX-1vSk6sRxgSre6n2r1jaH
f2Dn0KIYBfAQgeYeu_kbjySlCpZEoiN11PlwRFm8nSUfgfsgF7gjcILgfrC
E/pub
● Macrophages are found in tissues and are the product of one of the cell lineages
in the bone marrow. What is this cell lineage? #3
● A. Monocytic
● B. B-lymphocytic
● C. Granulocytic
● D. T-lymphocytic
● E. Megakaryocytic
○ A. Monocytic
● Which of the findings IS NOT FOUND in Disseminated Intravascular Coagulation
Syndrome in sepsis: #1
● A. Thrombocytopenia
● B. Reduced activity of Antithrombin III
● C. Short reptilase time
● D. Increased fibrin-degradation products
● E. Low fibrinogen
○ C. Short reptilase time
● Changes in which factors affects activated partial thromboplastin time (aPTT): #1
● A. Plasma + phospholipids + calcium
● B. Plasma + thromboplastin + calcium
● C. Plasma + phospholipids + thromboplastin
● D. Plasma + plasmin + calcium
● E. None of the above
○ A. Plasma + phospholipids + calcium
● The so-called "B symptoms" are described in a group of malignant haematological
diseases and is due to the secretion of pathological cytokines. It includes fever,
weight loss, abundant night sweats and persistent itching. In which of the
following diseases these symptoms determine the magnitude of its activity #1
● A. Chronic leukemias
● B. Hodgkin's Disease
● C. Myeloma
● D. Gaucher's Disease
● E. Acute leukemias
, ○ B. Hodgkin's Disease
● B cell lymphomas are characterized by the following cell markers and a
combination of monoclonal antibodies that are used for immunohistochemical
diagnosis: #1
● A. CD3, CD5, CD7
● B. CD10, CD20, CD23
● C. CD11, Cyclin D1, vimentin
● D. CD13, CD33, CD14
● E. None of the listed combinations
○ B. CD10, CD20, CD23
● What are the primary (central) lymphoid organs: #1
● A. Lymph nodes
● B. Liver, spleen, thymus
● C. Thymus, bone marrow
● D. Lymph nodes, spleen
● D. Spleen, liver
○ C. Thymus, bone marrow
● What is typical for immunoglobulin G (IgG): #1
● A. It is the most common - 80% of all immunoglobulin classes in serum
● B. It is the main immunoglobulin in mucous secretions
● C. It is involved in the late hypersensitivity reaction
● D. It is produced first in the immune response to an antigen
● E. All of the above are true
○ A. It is the most common - 80% of all immunoglobulin classes in serum
● In which cases are we talking about thalassemia intermedia: #1
● A. With a hemoglobin level between 70 and 100 g/l
● B. For heterozygous or homozygous forms
● C. In presence of microcytes and hypochromia
● D. The levels of HbA2 and HbF are increased
● E. All of the above
○ E. All of the above
● Which of the diseases listed below may manifest with ankylosis of the large joints
as a Complication: #1
● A. Thalassemia
● B. Down Syndrome
● C. Hemophilia
● D. Acute leukemia
● E. None of these
○ C. Hemophilia
,● A 28 years-old patient noticed bruises a week ago. He suffered from fatigue as
well. From the CBC: Hb 100 g/L; Leucocytes 1,3 G/L; Platelets 18 G/L. The blood
smear revealed granulated blast cells. The cytogenetical analysis showed t(15;17).
What is your diagnosis: #1
● A. Acute lymphoblastic leukemia
● B. Infectious mononucleosis
● C. Immune thrombocytopenia
● D. Leukemoid reaction
● E. Acute promyelocytic leukemia
○ E. Acute promyelocytic leukemia
● Complete remission achievement is the goal of treatment of acute leukemia.
Which of the parameters confirms complete remission: #1
● A. Blast cells in bone marrow <5%
● B. No organ infiltration signs
● C. Hemoglobin >100 g/L
● D. Platelets >100 G/L
● E. all of the above
○ E. all of the above
● What is the goal of the induction therapy in the treatment of AML: #2
● A. Normalizing the hemoglobin
● B. Prolongation of the life span
● C. Remission achievement
● D. Decreasing the blast percentage in bone marrow
● E. Overcome the hemorrhagic diathesis
○ C. Remission achievement
● What treatment is recommended for refractory myeloma: #1
● A. Experimental targeted therapy
● B. Treatment with Alkeran + Prednisolone
● C. Monoclonal Antibody - MabТhera
● D. Polychemotherapy with cytostatics from different pharmacological groups
● E. Autologous stem cell transplantation
○ A. Experimental targeted therapy
, ● The picture shows: #1
● A. Normal erythrocytes
● B. Megalocytes
● C. Anulocytes
● D. Rouleaux formations
● E. Red cell agglutination
○ D. Rouleaux formations
● In which disease is monoclonal paraprotein type IgA proven? #1
● A. Follicular lymphoma
● B. Autoimmune haemolytic anemia
● C. Chronic lymphocytic leukemia
● D. Multiple myeloma
● E. Chronic lymphocytic leukemia
○ D. Multiple myeloma
● Extreme splenomegaly of more than 1 kilogram weight is commonly related to: #1
● A. Infectious mononucleosis
● B. Primary myelofibrosis
● C. Sepsis
● D. Chronic right heart failure
● E. Chronic lymphocytic leukemia
○ B. Primary myelofibrosis
● Woman, 57y, complains of discomfort below the left rib cage which turns into
pain. Splenomegaly (+ 4cm) is revealed. From the CBC: hemoglobin 121 g/L,
leukocytes 56 G/L and platelets 358 G/L. The blood smear below is related most
likely to: #1
