Test questions
Case 1
1. Describe the pathway of light and its effect on melatonin. (Mention which tract, 2 nuclei and
1 gland)
2. How do the following factors influence the circadian rhythm? (phase delay/advance)
a. Exercise
b. Electric light
c. Drop in body temperature
d. Time of eating
3. What is the effect of the following genes:
a. REVERB
b. ROR
c. BMAL1
Case 2
4. What is the negative feedback mechanism of CREB?
5. Name 3 proteins that influence BMAL1?
6. Explain how an increase in ATP/AMP can lead to stimulation of SIRT1.
Case 3
7. What is the secretion/production place and function of these hormones?
a. Prolactin
b. Melatonin
c. Vasopressin
d. Cortisol
8. Explain the G protein signal transduction.
9. How does the MC4R pathway control food intake?
Case 4
10. Explain how dopamine release leads to an increased desire of food.
11. What are the 2 adiposity signals and why are there only 2?
12. What hypothalamic region is anabolic, thus suppressing the activity of satiety signals?
Case 5
13. What is the most important determinant of BMR, explaining why BMR is higher in men?
14. How does non-shivering thermogenesis work?
15. Name 3 causes for obesity.
Case 6
16. How does modernization lead to increased obesity? (primary/tertiary work fields)
17. Do these social characteristics decrease or increase body weight?
a. Parenthood
b. Big household
c. Divorcing
18. How does the ability of having clocks and clothes influence body weight?
Case 1
1. Describe the pathway of light and its effect on melatonin. (Mention which tract, 2 nuclei and
1 gland)
2. How do the following factors influence the circadian rhythm? (phase delay/advance)
a. Exercise
b. Electric light
c. Drop in body temperature
d. Time of eating
3. What is the effect of the following genes:
a. REVERB
b. ROR
c. BMAL1
Case 2
4. What is the negative feedback mechanism of CREB?
5. Name 3 proteins that influence BMAL1?
6. Explain how an increase in ATP/AMP can lead to stimulation of SIRT1.
Case 3
7. What is the secretion/production place and function of these hormones?
a. Prolactin
b. Melatonin
c. Vasopressin
d. Cortisol
8. Explain the G protein signal transduction.
9. How does the MC4R pathway control food intake?
Case 4
10. Explain how dopamine release leads to an increased desire of food.
11. What are the 2 adiposity signals and why are there only 2?
12. What hypothalamic region is anabolic, thus suppressing the activity of satiety signals?
Case 5
13. What is the most important determinant of BMR, explaining why BMR is higher in men?
14. How does non-shivering thermogenesis work?
15. Name 3 causes for obesity.
Case 6
16. How does modernization lead to increased obesity? (primary/tertiary work fields)
17. Do these social characteristics decrease or increase body weight?
a. Parenthood
b. Big household
c. Divorcing
18. How does the ability of having clocks and clothes influence body weight?
