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NR 566 Week 2 Assignment; HIV National Curriculum - Antiretroviral Therapy

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esson 1 Quiz: Antiretroviral Medications and Initial Therapy 1. Question: What result is required for maraviroc to be considered appropriate for use? 2. Question: Which one of the following medications requires phosphorylation to become active as an inhibitor of HIV? 3. Question: According to the Adult and Adolescent ARV Guidelines, at what CD4 threshold should antiretroviral therapy by recommended for persons with HIV? 4. Question: According to the Adult and Adolescent ARV Guidelines, which one of the following is classified as a recommended initial regimen for most people with HIV? 5. Question: After starting the antiretroviral therapy, when should the next HIV RNA level be checked? Lesson 2 Quiz: Adverse Effects of Antiretroviral Medications 1. Question: Which one of the following antiretroviral therapy regimens has been most clearly associated with weight gain? 2. Question: Which one of the following medications requires baseline HLA-B*5701 testing to identify persons at increased risk of developing a medication-related hypersensitivity reaction? 3. Question: Which organs are most likely to be adversely impacted by long-term tenofovir DF therapy 4. Question: What is the most likely explanation for this small, but persistent increase in serum creatinine? 5. Question: Atazanavir causes hyperbilirubinemia by inhibiting what enzyme? Lesson 3 Quiz: Drug Interactions with Antiretroviral Medications 1. Question: Which superfamily of enzymes is responsible for the metabolism of more than half of all antiretroviral medications? 2. Question: Which one of the following antiretroviral medications is most likely to have levels decreased if taken with a proton-pump inhibitor? 3. Question: What impact will this antiretroviral therapy switch likely have on methadone levels during the next 6 weeks? 4. Question: Which one of the following can be a serious complication of coadministration of ritonavir and inhaled fluticasone? 5. Question: Which one of the following antiretroviral medications should be avoided in a patient taking rifampin?

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1
Maraviroc is being considered as a part of the new antiretroviral regimen and an HIV
tropism coreceptor assay is ordered.
What result is required for maraviroc to be considered appropriate for use?
R5-tropic HIV
Mixed-tropic HIV
X4-tropic HIV
Dual-tropic HIV

2
Which one of the following medications requires phosphorylation to become
active as an inhibitor of HIV?
Etravirine
Lamivudine
Atazanavir
Raltegravir

3
According to the Adult and Adolescent ARV Guidelines, at what CD4 threshold
should antiretroviral therapy by recommended for persons with HIV
infection?
When the CD4 count declines to less than 500 cells/mm3
When the CD4 count declines to less than 200 cells/mm3
When the CD4 count declines to less than 350 cells/mm3
Antiretroviral therapy is recommended for all, regardless of CD4 cell count

4
According to the Adult and Adolescent ARV Guidelines, which one of the
following is classified as a recommended initial regimen for most people with
HIV?
Doravirine-tenofovir DF-emtricitabine
Efavirenz-tenofovir DF-emtricitabine
Dolutegravir plus tenofovir alafenamide-emtricitabine
Darunavir plus ritonavir plus tenofovir alafenamide-emtricitabine

5
What is the mechanism of action of the nucleoside transcriptase inhibitors
(NRTIs)?
Induction of a conformation change in the reverse transcriptase enzyme
Incorporation into the elongating primer strand of HIV DNA with resultant chain termination
Binding to the RNase H region of reverse transcriptase with result separation of the p66 and
p51 subunits
Enzyme inhibition through binding of the polymerase domain binding pocket




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https://www.coursehero.com/file/56021499/HIV-Questionsdocx/

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