UNE biochem Unit 1 Test, Medical Biochemistry Unit 1
Week 2 Assessment, Week 1 Evaluation, Week 1, Q&A, Mod
1 and 2, Week 1 pre-quiz questions, Unit 1
Allopurinol is an inhibitor of Xanthine Oxidase. Addition of this
compound will result in a decrease in what compound? correct
answer: Uric Acid
DNA replication occurs during which phase of the cell cycle?
correct answer: S phase
The affinity for DNA and histones within a chromosome can be
increased by which of the following histone modifications?
correct answer: Deaceytlation
DNA replication on both the leading and the lagging strand
proceeds in the 5' to 3' direction. The remaining over hand on
the lagging strand requires priming from which of the following
enzymes in order for the gap to be filled? correct answer:
Telomerase
Which of the following is the regulatory enzyme in pyrimidine
synthesis? correct answer: Carbamoyl phosphate synthetase II
You are counseling a family with regards to myotonic dystrophy
which is an autosomal dominant disorder. One of the individuals
is affected by this disorder (genotype Rr) while the other is not.
What is the likelihood that their child will not be impacted by
myotonic dystrophy? correct answer: 50%
,Cobalamin (B12) supplementation would be most appropriate to
enhance the activity of which of the following enzymes? correct
answer: Methionine Synthase
In the case of a deficiency in phenylalanine hydroxylase which
of the following amino acids will become essential? correct
answer: Tyrosine
Phenylketonuria (PKU) is an autosomal recessive disorder that
can be caused by a defect in phenylalanine hydroxylase. PKU
can also present due to a deficiency in which of the following
vitamins or cofactors? correct answer: Tetrahydrobiopterin (B4)
A 2-year-old boy is recently diagnosed with red-green blindness
which is an X-linked recessive disorder. Which of the following
represents the correct genotypes of this individual's parents with
respect to red-green color blindness? (X-wild type, X'- recessive
allele; R wild type autosomal allele; r recessive autosomal allele
and Y chromosome) correct answer: Mom X'X and Dad XY
Which of the following amino acids could be readily modified
by phosphorylation? correct answer: Tyrosine
In the image above the blue line indicates enzyme kinetics with
no inhibitor present. Based on this information which of the
following is true? correct answer: The green line shows enzyme
kinetics with the addition of a noncompetitive inhibitor
What is the [H+] concentration in a 0.001M = 10^-3 M solution
of NaOH. (10^-14 = [H+][OH-]) correct answer: 10^-11 M
,When an enzyme is present in the R-conformation it usually
binds which of the following with the greatest affinity? correct
answer: An allosteric activator
Histidine has 3 ionizable groups. The pKa of the alpha COOH is
1.8, pKa on the R group is 6.0; the pKa on the alpha-amino
group is 9.3. At a pH of 5, what would the net charge on
histidine be? correct answer: +1
A mutation that activates the kinase domain of a protein will
result in: correct answer: An increase in the phosphorylation of
its target protein
A frame shift mutation where 5 nucleotides are introduced
randomly within an mRNA transcript will result in: correct
answer: Shifting of the reading frame such that all amino acids
downstream of the insertion are changed
In the absence of iron, the iron response element binding protein
(IRE-BP) binds the mRNA encoding for ferritin and inhibits
protein translation. This type of gene regulation is best described
as: correct answer: Translational regulation
A mutation occurs in the GRE (glucocorticoid response
element). This mutation makes the GRE unrecognizable by the
receptor/ligand complex. What impact would this have on the
transcription of the gene downstream of this element? correct
answer: Transcription of the downstream gene will not occur
even in the presence of the receptor ligand complex
, Which of the following is an example of post translational
modification? correct answer: Phosphorylation of glycogen
phosphorylase
From the list below, please select all of the necessary events in
tRNA processing and maturation.
1. Addition of 3' amino acid attachment site
2. Addition of a 3' Poly A tail
3. Addition of a 5' cap
4. Removal of introns
5. Modification of bases correct answer: 1, 4, and 5 only
Which of the following best describes a missense mutation?
correct answer: A single change to the DNA sequence that
results in amino acid change in the primary sequence
Which of the following is needed to facilitate protein targeting
to its appropriate sub-cellular location? correct answer: Peptide
signal sequence
Which of the following genetic elements is within the
transcribed region of a gene? correct answer: Translational start
site
During protein translation, (after the initiation complex is
formed), the addition of each amino acid to the growing
polypeptide chain involves aminoacyl-tRNAs binding to which
site on the ribosome? correct answer: A site
Week 2 Assessment, Week 1 Evaluation, Week 1, Q&A, Mod
1 and 2, Week 1 pre-quiz questions, Unit 1
Allopurinol is an inhibitor of Xanthine Oxidase. Addition of this
compound will result in a decrease in what compound? correct
answer: Uric Acid
DNA replication occurs during which phase of the cell cycle?
correct answer: S phase
The affinity for DNA and histones within a chromosome can be
increased by which of the following histone modifications?
correct answer: Deaceytlation
DNA replication on both the leading and the lagging strand
proceeds in the 5' to 3' direction. The remaining over hand on
the lagging strand requires priming from which of the following
enzymes in order for the gap to be filled? correct answer:
Telomerase
Which of the following is the regulatory enzyme in pyrimidine
synthesis? correct answer: Carbamoyl phosphate synthetase II
You are counseling a family with regards to myotonic dystrophy
which is an autosomal dominant disorder. One of the individuals
is affected by this disorder (genotype Rr) while the other is not.
What is the likelihood that their child will not be impacted by
myotonic dystrophy? correct answer: 50%
,Cobalamin (B12) supplementation would be most appropriate to
enhance the activity of which of the following enzymes? correct
answer: Methionine Synthase
In the case of a deficiency in phenylalanine hydroxylase which
of the following amino acids will become essential? correct
answer: Tyrosine
Phenylketonuria (PKU) is an autosomal recessive disorder that
can be caused by a defect in phenylalanine hydroxylase. PKU
can also present due to a deficiency in which of the following
vitamins or cofactors? correct answer: Tetrahydrobiopterin (B4)
A 2-year-old boy is recently diagnosed with red-green blindness
which is an X-linked recessive disorder. Which of the following
represents the correct genotypes of this individual's parents with
respect to red-green color blindness? (X-wild type, X'- recessive
allele; R wild type autosomal allele; r recessive autosomal allele
and Y chromosome) correct answer: Mom X'X and Dad XY
Which of the following amino acids could be readily modified
by phosphorylation? correct answer: Tyrosine
In the image above the blue line indicates enzyme kinetics with
no inhibitor present. Based on this information which of the
following is true? correct answer: The green line shows enzyme
kinetics with the addition of a noncompetitive inhibitor
What is the [H+] concentration in a 0.001M = 10^-3 M solution
of NaOH. (10^-14 = [H+][OH-]) correct answer: 10^-11 M
,When an enzyme is present in the R-conformation it usually
binds which of the following with the greatest affinity? correct
answer: An allosteric activator
Histidine has 3 ionizable groups. The pKa of the alpha COOH is
1.8, pKa on the R group is 6.0; the pKa on the alpha-amino
group is 9.3. At a pH of 5, what would the net charge on
histidine be? correct answer: +1
A mutation that activates the kinase domain of a protein will
result in: correct answer: An increase in the phosphorylation of
its target protein
A frame shift mutation where 5 nucleotides are introduced
randomly within an mRNA transcript will result in: correct
answer: Shifting of the reading frame such that all amino acids
downstream of the insertion are changed
In the absence of iron, the iron response element binding protein
(IRE-BP) binds the mRNA encoding for ferritin and inhibits
protein translation. This type of gene regulation is best described
as: correct answer: Translational regulation
A mutation occurs in the GRE (glucocorticoid response
element). This mutation makes the GRE unrecognizable by the
receptor/ligand complex. What impact would this have on the
transcription of the gene downstream of this element? correct
answer: Transcription of the downstream gene will not occur
even in the presence of the receptor ligand complex
, Which of the following is an example of post translational
modification? correct answer: Phosphorylation of glycogen
phosphorylase
From the list below, please select all of the necessary events in
tRNA processing and maturation.
1. Addition of 3' amino acid attachment site
2. Addition of a 3' Poly A tail
3. Addition of a 5' cap
4. Removal of introns
5. Modification of bases correct answer: 1, 4, and 5 only
Which of the following best describes a missense mutation?
correct answer: A single change to the DNA sequence that
results in amino acid change in the primary sequence
Which of the following is needed to facilitate protein targeting
to its appropriate sub-cellular location? correct answer: Peptide
signal sequence
Which of the following genetic elements is within the
transcribed region of a gene? correct answer: Translational start
site
During protein translation, (after the initiation complex is
formed), the addition of each amino acid to the growing
polypeptide chain involves aminoacyl-tRNAs binding to which
site on the ribosome? correct answer: A site
