Hematology (MLS ASCP) | 191 Questions With
Verified Solution | 2023
Bone marrow and peripheral blood
growth factors that stimulate the Cell Lines
Flat Bones which include: Skull, Sternum, Pelvis, Vertebrae and the Ribs
Sites of active bone marrow in adults
myeloblast
immature bone marrow that gives rise to granulocytes
Promyelocyte
an immature, developing form of blood cell
myelocyte
an immature cell that comes from a myeloblast in the red marrow and develops into
either a neutrophil, eosinophil, or basophil
Metamyelocyte
transitional cell intermediate in development between a myelocyte and a mature
granular leukocyte
Band Neutrophil
immature neutrophil
segmented neutrophil
white blood cell most often seen when performing a differential
monoblast
immature monocyte
Promonocyte
a cell arising from a monoblast, leaving the bone marrow and developing into a
monocyte.
monocyte
*A type of white blood cell that transforms into macrophages, extends pseudopods, and
engulfs huge numbers of microbes over a long period of time
*An agranular leukocyte that is able to migrate into tissues and transform into a
macrophage.
Macrophages
Amoeboid cells that roam connective tissue and engulf foreign particles and debris of
dead cells.
Basophils
A circulating leukocyte that produces histamine and heparin
Eosinophils
a white blood cell containing granules that are readily stained by eosin.
Rubriblast (Pronormoblast)
Earliest Recognizable RBC Precursor
Prorubricyte (Basophilic Normoblast)
Last stage with a nucleolus. Very blue cytoplasm
Rubricyte
A stage of development of red blood cells between the prorubricyte and the
metarubricyte
, Metarubricyte (Orthochromic Normoblast)
nucleated RBC
Reticulocyte
second to last stage of a red blood cell
Lymphoblast
immature lymphocyte
Prolymphocyte
derived from a lymphoblast, immediate precursor of a lymphocyte.
Lymphocytes
A type of white blood cell that make antibodies to fight off infections. T-Cells, B-Cells,
and Natural Killer Cells
Megakaryoblast
cell that produces platelets and is found in bone marrow, large cell, single round
nucleus,becomes promegakaryocyte
Promegakaryocyte
stage of thrombocyte maturation where granules begin to form
megakaryocyte
a large bone marrow cell from which platelets are derived
platelet (thrombocyte)
cell fragment involved in clotting process
Transferrin
iron transport protein
Ferritin
storage form of iron
Hemosiderin
Iron storage form made during iron overload. Used for long-term storage.
Hemochromatosis
hereditary disorder with an excessive buildup of iron deposits in the body. Caused by
mutation in C282Y
Hemosiderosis
condition of iron overloading caused by the large breakdown of red blood cells
Heme synthesis
process needs two parts: Iron and protoporphyrin
Precursors - DELTA-aminolevulinic acid --> PORphobilinogen -->
URoporphyrinogen --> COProporphyrinogen --> PROTOporphyrin --> HEME +
globin 4 hemoglobin
What are the steps to Protoporphyrin Synthesis?
Porphyrias
diseases that result from deficiencies of any of several enzymes required to make heme
Hgb F
hemoglobin highest in newborns, 2 alpha and 2 gamma seen in
Hgb A
2 alpha and 2 beta, highest in adults
hemoglobin dissociation curve
a plot of the percent of hemoglobin that is saturated with oxygen (y axis) vs. oxygen
partial pressure (x axis)
Verified Solution | 2023
Bone marrow and peripheral blood
growth factors that stimulate the Cell Lines
Flat Bones which include: Skull, Sternum, Pelvis, Vertebrae and the Ribs
Sites of active bone marrow in adults
myeloblast
immature bone marrow that gives rise to granulocytes
Promyelocyte
an immature, developing form of blood cell
myelocyte
an immature cell that comes from a myeloblast in the red marrow and develops into
either a neutrophil, eosinophil, or basophil
Metamyelocyte
transitional cell intermediate in development between a myelocyte and a mature
granular leukocyte
Band Neutrophil
immature neutrophil
segmented neutrophil
white blood cell most often seen when performing a differential
monoblast
immature monocyte
Promonocyte
a cell arising from a monoblast, leaving the bone marrow and developing into a
monocyte.
monocyte
*A type of white blood cell that transforms into macrophages, extends pseudopods, and
engulfs huge numbers of microbes over a long period of time
*An agranular leukocyte that is able to migrate into tissues and transform into a
macrophage.
Macrophages
Amoeboid cells that roam connective tissue and engulf foreign particles and debris of
dead cells.
Basophils
A circulating leukocyte that produces histamine and heparin
Eosinophils
a white blood cell containing granules that are readily stained by eosin.
Rubriblast (Pronormoblast)
Earliest Recognizable RBC Precursor
Prorubricyte (Basophilic Normoblast)
Last stage with a nucleolus. Very blue cytoplasm
Rubricyte
A stage of development of red blood cells between the prorubricyte and the
metarubricyte
, Metarubricyte (Orthochromic Normoblast)
nucleated RBC
Reticulocyte
second to last stage of a red blood cell
Lymphoblast
immature lymphocyte
Prolymphocyte
derived from a lymphoblast, immediate precursor of a lymphocyte.
Lymphocytes
A type of white blood cell that make antibodies to fight off infections. T-Cells, B-Cells,
and Natural Killer Cells
Megakaryoblast
cell that produces platelets and is found in bone marrow, large cell, single round
nucleus,becomes promegakaryocyte
Promegakaryocyte
stage of thrombocyte maturation where granules begin to form
megakaryocyte
a large bone marrow cell from which platelets are derived
platelet (thrombocyte)
cell fragment involved in clotting process
Transferrin
iron transport protein
Ferritin
storage form of iron
Hemosiderin
Iron storage form made during iron overload. Used for long-term storage.
Hemochromatosis
hereditary disorder with an excessive buildup of iron deposits in the body. Caused by
mutation in C282Y
Hemosiderosis
condition of iron overloading caused by the large breakdown of red blood cells
Heme synthesis
process needs two parts: Iron and protoporphyrin
Precursors - DELTA-aminolevulinic acid --> PORphobilinogen -->
URoporphyrinogen --> COProporphyrinogen --> PROTOporphyrin --> HEME +
globin 4 hemoglobin
What are the steps to Protoporphyrin Synthesis?
Porphyrias
diseases that result from deficiencies of any of several enzymes required to make heme
Hgb F
hemoglobin highest in newborns, 2 alpha and 2 gamma seen in
Hgb A
2 alpha and 2 beta, highest in adults
hemoglobin dissociation curve
a plot of the percent of hemoglobin that is saturated with oxygen (y axis) vs. oxygen
partial pressure (x axis)
