1
Pharmacology Discussion Board 1 Updated in June
and with Recent References
She believes her patient's fat percentage to lean body mass change with lack of exercise and
increased fat stores is key to the answer. Do you agree?
I concur with Jane's assertion that a lack of physical activity could result in a change in her body
mass. Lean body mass increases as a result of weight reduction, which, according to Lee & Lee
(2021), is caused by physical activity and exercise. Because of this, the shift in lean body mass
can be linked to a decrease in exercise and an overall increase in fat storage. The issue cannot,
however, just stem from this .
Your classmate also knows there are alterations in the CYP450 cytochrome system in aging.
What can you offer to help her answer the preceptor’s request?
For the detoxification of xenobiotics, cellular metabolism, and homeostasis, the CYP450
cytochrome enzyme is essential. However, age is relative, and as a person becomes older, their
CYP450 cytochrome system performs worse (Wautheir et al., 2017). As a result, the
pharmacokinetics and pharmacodynamics are impacted, which increases the likelihood of drug-
drug interactions and raises the likelihood that a medicine will have unfavorable side effects.
Consequently, the ongoing daytime sleepiness and rise in lean body mass can be linked to these
physical changes..
Pharmacology Discussion Board 1 Updated in June
and with Recent References
She believes her patient's fat percentage to lean body mass change with lack of exercise and
increased fat stores is key to the answer. Do you agree?
I concur with Jane's assertion that a lack of physical activity could result in a change in her body
mass. Lean body mass increases as a result of weight reduction, which, according to Lee & Lee
(2021), is caused by physical activity and exercise. Because of this, the shift in lean body mass
can be linked to a decrease in exercise and an overall increase in fat storage. The issue cannot,
however, just stem from this .
Your classmate also knows there are alterations in the CYP450 cytochrome system in aging.
What can you offer to help her answer the preceptor’s request?
For the detoxification of xenobiotics, cellular metabolism, and homeostasis, the CYP450
cytochrome enzyme is essential. However, age is relative, and as a person becomes older, their
CYP450 cytochrome system performs worse (Wautheir et al., 2017). As a result, the
pharmacokinetics and pharmacodynamics are impacted, which increases the likelihood of drug-
drug interactions and raises the likelihood that a medicine will have unfavorable side effects.
Consequently, the ongoing daytime sleepiness and rise in lean body mass can be linked to these
physical changes..
