Pairwise Sequence Alignme
, Pairwise Sequence Al
• Sequence comparison lies at the heart of bioinformatic
analysis.
• It is an important first step toward structural and
functional analysis of newly determined sequences.
• The most fundamental process in this type of comparis
is sequence alignment.
, Pairwise Sequence Al
• Pairwise sequence alignment is the process of alignin
two sequences and is the basis of database similarity
searching.
• sequences are compared by searching for common
character patterns and establishing residue–residue
correspondence among related sequences.
, EVOLUTIONARY BA
• DNA and proteins are products of evolution.
• Nucleotide bases, and amino acids form linear
sequences that
• determine the primary structure of the molecules.
• These molecules can be considered molecular fossils
encode the history of millions of years of evolution.
, Pairwise Sequence Al
• Sequence comparison lies at the heart of bioinformatic
analysis.
• It is an important first step toward structural and
functional analysis of newly determined sequences.
• The most fundamental process in this type of comparis
is sequence alignment.
, Pairwise Sequence Al
• Pairwise sequence alignment is the process of alignin
two sequences and is the basis of database similarity
searching.
• sequences are compared by searching for common
character patterns and establishing residue–residue
correspondence among related sequences.
, EVOLUTIONARY BA
• DNA and proteins are products of evolution.
• Nucleotide bases, and amino acids form linear
sequences that
• determine the primary structure of the molecules.
• These molecules can be considered molecular fossils
encode the history of millions of years of evolution.
