A 32-year-old woman was treated for mantle cell lymphoma with a nonmyeloablative bone
marrow transplant. Before the transplant and after a donor was selected, STR analysis was
performed on the donor and the recipient to find informative alleles. One hundred days after the
transplant, engraftment was evaluated using the selected STR alleles. The results from one
marker, D5S818, are shown in the top panel. One year later, the patient was reevaluated. The
results from the same marker are shown in the bottom panel. Results from engraftment analysis
at 100 days (top) and 1 year (bottom) showing marker D5S818. R. recipient; D, donor Was the
woman successfully engrafted with donor cells? Explain your answer.
Solution
The woman has not successfully engrafted of the donor cells it is because the size of allele at 135
Mb DNA position is not same as the donor. The donor allele size is still 61188 bp but the
recipient has 53400 bp allele size after 1 year of engraftation. The size should be equal to work
efficiently or functionally inside the cell.
marrow transplant. Before the transplant and after a donor was selected, STR analysis was
performed on the donor and the recipient to find informative alleles. One hundred days after the
transplant, engraftment was evaluated using the selected STR alleles. The results from one
marker, D5S818, are shown in the top panel. One year later, the patient was reevaluated. The
results from the same marker are shown in the bottom panel. Results from engraftment analysis
at 100 days (top) and 1 year (bottom) showing marker D5S818. R. recipient; D, donor Was the
woman successfully engrafted with donor cells? Explain your answer.
Solution
The woman has not successfully engrafted of the donor cells it is because the size of allele at 135
Mb DNA position is not same as the donor. The donor allele size is still 61188 bp but the
recipient has 53400 bp allele size after 1 year of engraftation. The size should be equal to work
efficiently or functionally inside the cell.
