A codon that specifies the amino acid His undergoes a single-base substitution that yields a
codon that specifies Arg. Refer to the genetic code table and give all possible DNA sequences
for the original and the mutated codon. Is the mutation a transition or a transversion?
Solution
Histidine produce from codons:
CAC, CAT
While arginine is coded from CGA CGT, AGA CGC, CGG, AGG
So single base mutations in the codons CAC, CAT of Hisitidine will be results in the codons
CGC CGT of arginine respectively
Conversion by substitution A of CAC = into G of CGC by transition mutation of Adinine (A)
into Guanine (G).
Conversion by substitution A of CAT = into G of CGT by transition mutation of Adinine (A)
into Guanine (G).
codon that specifies Arg. Refer to the genetic code table and give all possible DNA sequences
for the original and the mutated codon. Is the mutation a transition or a transversion?
Solution
Histidine produce from codons:
CAC, CAT
While arginine is coded from CGA CGT, AGA CGC, CGG, AGG
So single base mutations in the codons CAC, CAT of Hisitidine will be results in the codons
CGC CGT of arginine respectively
Conversion by substitution A of CAC = into G of CGC by transition mutation of Adinine (A)
into Guanine (G).
Conversion by substitution A of CAT = into G of CGT by transition mutation of Adinine (A)
into Guanine (G).
