littleor no azotemia, hematuria, HTN -Nephrotic syndrome -
hyperlipidemic lipiduria
d
massive proteinuria
b
hypoalbuminemia
Generalized edema
① Minima disease
focal segmental Glomerulosclerosis. ③ membranous nephropathy
-
benign, most common cause ofNephrotic not all
* glomeruli I onlysegments of glomerulus- Immune complex deposition in glomer.
*
syndrome in children. xmaybe primary (20-30) for secondary (AIDS, heroin a could be:
abuse, nephron loss etc. ①
Primary (idiopathic) 85%:Ab agave
...
-
T-cell derived factor causes podocytes -
injury to podocytes, initiallyGFR but then b GR PLAIR.
effacement A damage ② Secondary:infections,tumors, auto
-
LM(HA) esclerosis. immune diseases, inorganic salt exposure
LM(H1Z) -e normal glomeruli EM is effacemento f
foot processes
drugs.
- -
EM-> effacement
-
offootprocesses 15 Negative -
me -
LM e diffuse thickening ofGBM
of podocytes Clinically:Ohematuria & HTN non selective
* -
EM subepithelial dome spikes
·
If negative, no immune deposits.
-s
probeinuria - If
Positive (IgG)
*
Clinically:Dnephrotic syndrome * sosuffer renal failure after 10 years clinically:nephrotic syndrome
*
& No HTN &selective profeinuria Calbumin)A poor response to corticosteroids -
Poor response to corticosteroids.
④ renal function preserved Good prognosis.A adults do worse than children -
60%Proteinuria
persists. Usu
Collapsing lomerulopallym, orphologyinvariantofapain.Progresserrecallanemissionin
frx:90% corticosteroids //4% chronic renal failure
*In adults with MCD response is slower
relapses
* are more common. can
* be:OIdiopathicassociated w/HIV infection proteinuria
③ Drug induced toxicity
hyperlipidemic lipiduria
d
massive proteinuria
b
hypoalbuminemia
Generalized edema
① Minima disease
focal segmental Glomerulosclerosis. ③ membranous nephropathy
-
benign, most common cause ofNephrotic not all
* glomeruli I onlysegments of glomerulus- Immune complex deposition in glomer.
*
syndrome in children. xmaybe primary (20-30) for secondary (AIDS, heroin a could be:
abuse, nephron loss etc. ①
Primary (idiopathic) 85%:Ab agave
...
-
T-cell derived factor causes podocytes -
injury to podocytes, initiallyGFR but then b GR PLAIR.
effacement A damage ② Secondary:infections,tumors, auto
-
LM(HA) esclerosis. immune diseases, inorganic salt exposure
LM(H1Z) -e normal glomeruli EM is effacemento f
foot processes
drugs.
- -
EM-> effacement
-
offootprocesses 15 Negative -
me -
LM e diffuse thickening ofGBM
of podocytes Clinically:Ohematuria & HTN non selective
* -
EM subepithelial dome spikes
·
If negative, no immune deposits.
-s
probeinuria - If
Positive (IgG)
*
Clinically:Dnephrotic syndrome * sosuffer renal failure after 10 years clinically:nephrotic syndrome
*
& No HTN &selective profeinuria Calbumin)A poor response to corticosteroids -
Poor response to corticosteroids.
④ renal function preserved Good prognosis.A adults do worse than children -
60%Proteinuria
persists. Usu
Collapsing lomerulopallym, orphologyinvariantofapain.Progresserrecallanemissionin
frx:90% corticosteroids //4% chronic renal failure
*In adults with MCD response is slower
relapses
* are more common. can
* be:OIdiopathicassociated w/HIV infection proteinuria
③ Drug induced toxicity
