By : Noor Almomani
Grg8
-1888 ar3835
In
* all cases of breast cancer, we examine (ERreceptors,PR receptors, and HER2/new receptor
->
ER positive (HER2 negative; -601)
↑ ② (infiltrative)
I
Non invasive -
HER2 positive (ER positive or
negative's =201 Invasive
-
Triple negative (ER, PRIHER2 negative: =10i)
-
① lobular carcinoma in Situ & Ductal carcinoma in Situ. OInvasive ductal carcinoma Invasive lobular Carcinoma Carcinoma with Colloid Carcinoma Tubular Ca.
-
Malignant clonal proliferation within -
malignantclonal proliferation -
70% to 80% of cases 10-15% of all breast can medullary features mucinous
a carcinoma. 25%
lobules and ducts. within ducts and lobules. -
Precancerous lesion is 8- * Precancerous lesion
8-2 A 3% Grare subtype Clinically:
3
-
-
wide
-
cells
grow
in discohesive fashion -
DCIS have a
variety Ductal carcinoma in Situ 213 associated with lobular .Microscopically: -
Grossly:soft and Always detected
of histologic appearances clinical
presentation
due of the tumor Situ -large anaplastic cells
to
acquired loss -
carcinoma in gelatinous. as irregular
·
an
suppressive adhesion protein E-cadherin solid,comedos cribriform Mammographic density A multicentric bilateral with pushing, well -
Microscopically: mammographic
Named "lobular" because the papillary and micropapillary or hards palpable irregular (10-20%) circumscribed borders Tumor cells produce densities.
-
proliferation takes an
appearance masses. *
Clinically 8- with a pronounced abundant quantities of
-
Microscopic:
resembling lobules. Receptor Profile 3
*
mostpresenta s palpable lymphocytic infiltraten extracellular mucin thatwell formed
Usually CERPR #, HER 2=) masses or
mammographic densities a Precancerous
lesioning dissects into the surrounding tubules with low
* Receptor profile: 3 Usudly absent. stroma grade nuclei
ER, PRsHER2-) -
Increased in - L.N metastasis
* Histo logically: with BRCA mutations.
-
Receptor Profile is rare.
cells invade stroma
individualy -
Receptor Profile by (ERA, HER2-) -
Prognosis is
and often are aligned in Triple negative o excellent.
"Single file" -
Receptor Profile:
ER A ,
HER2 -)
A features common to all invasive cancers. A
spread ofBreast cancers:
Fixation: adherent to the pectoral muscles or deep fascia of the -Through lymphatic and hematogenous channels.
chest wall
-Favored mets are the bone, lungs, skeleton,
retraction or dimpling of the skin or nipple: adherence to the liver, and adrenals and (less commonly) the
overlying skin brain, spleen, and pituitary
peaud'o range (orange peel): Involvementofthe lymphatic pathways cause -Metastases may appear many years after
localized lymphedema, the skin becomes thickened and exaggerated around therapeutic control of the primary lesion
hair follicles
Grg8
-1888 ar3835
In
* all cases of breast cancer, we examine (ERreceptors,PR receptors, and HER2/new receptor
->
ER positive (HER2 negative; -601)
↑ ② (infiltrative)
I
Non invasive -
HER2 positive (ER positive or
negative's =201 Invasive
-
Triple negative (ER, PRIHER2 negative: =10i)
-
① lobular carcinoma in Situ & Ductal carcinoma in Situ. OInvasive ductal carcinoma Invasive lobular Carcinoma Carcinoma with Colloid Carcinoma Tubular Ca.
-
Malignant clonal proliferation within -
malignantclonal proliferation -
70% to 80% of cases 10-15% of all breast can medullary features mucinous
a carcinoma. 25%
lobules and ducts. within ducts and lobules. -
Precancerous lesion is 8- * Precancerous lesion
8-2 A 3% Grare subtype Clinically:
3
-
-
wide
-
cells
grow
in discohesive fashion -
DCIS have a
variety Ductal carcinoma in Situ 213 associated with lobular .Microscopically: -
Grossly:soft and Always detected
of histologic appearances clinical
presentation
due of the tumor Situ -large anaplastic cells
to
acquired loss -
carcinoma in gelatinous. as irregular
·
an
suppressive adhesion protein E-cadherin solid,comedos cribriform Mammographic density A multicentric bilateral with pushing, well -
Microscopically: mammographic
Named "lobular" because the papillary and micropapillary or hards palpable irregular (10-20%) circumscribed borders Tumor cells produce densities.
-
proliferation takes an
appearance masses. *
Clinically 8- with a pronounced abundant quantities of
-
Microscopic:
resembling lobules. Receptor Profile 3
*
mostpresenta s palpable lymphocytic infiltraten extracellular mucin thatwell formed
Usually CERPR #, HER 2=) masses or
mammographic densities a Precancerous
lesioning dissects into the surrounding tubules with low
* Receptor profile: 3 Usudly absent. stroma grade nuclei
ER, PRsHER2-) -
Increased in - L.N metastasis
* Histo logically: with BRCA mutations.
-
Receptor Profile is rare.
cells invade stroma
individualy -
Receptor Profile by (ERA, HER2-) -
Prognosis is
and often are aligned in Triple negative o excellent.
"Single file" -
Receptor Profile:
ER A ,
HER2 -)
A features common to all invasive cancers. A
spread ofBreast cancers:
Fixation: adherent to the pectoral muscles or deep fascia of the -Through lymphatic and hematogenous channels.
chest wall
-Favored mets are the bone, lungs, skeleton,
retraction or dimpling of the skin or nipple: adherence to the liver, and adrenals and (less commonly) the
overlying skin brain, spleen, and pituitary
peaud'o range (orange peel): Involvementofthe lymphatic pathways cause -Metastases may appear many years after
localized lymphedema, the skin becomes thickened and exaggerated around therapeutic control of the primary lesion
hair follicles
