PHARMACOLOGY THIRD YEAR
ANTIVIRALS AND ANTIFUNGALS
, ANTIVIRALS
ANTI INFLUENZA DRUGS
M2 Ion Channel Inhibitors --
Mechanism of Action -- it blocks the M2 channels, restricting
the pathway of the protons, which is necessary to trigger the
production of viral genome into the cell nucleus.
AMANTADINE
RIMANTADINE
Endonuclease Inhibitors –
Mechanism of Action -- Selectively inhibiting cap dependent
endonuclease, it is necessary to initiate influenza virus MRna
synthesis.
It prevents the viral transcription, which, leads to, influenza
viral replication.
BALOXAVIR
Neuraminidase Inhibitors –
Mechanism of Action -- Inhibition of neuraminidase enzyme.
It becomes unable to cleave to the sialic acid and the virus is
unable to escape from the cell.
OSELTAMIVIR
PERAMIVIR
ZANAMIVIR
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