ANTIVIRALS
*ANTI INFLUENZA DRUGS
influenza virus is enveloped virus, single stranded,
segmental Rnas
the viral envelope is made up of lipid bilayer,
1. Hemagluttin
2. Neuraminidase
3. Matrix 2
^ the binding of hemagluttin to Salic acid residues in the surface of the host
cell results in, engulfment of the virus into the cell, via endocytosis.
^ M2 forms pH gated channels that allows the protons to move through the
viral envelope and acidify the core of the virus, which, leads to, release of viral
Rnas and proteins, it is transported to the cell membrane.
^ in the cell nucleus, the viral Rna is transcribed into messenger Rna (MRna )
^ The MRna undergoes, translation, in the ribosomes to viral proteins
^ Once synthesized, hemagluttin, neuraminidase and glycoproteins are
secreted through the Golgi apparatus onto the cell surface where they fuse
with the plasma membrane
^ other viral proteins, migrate to the cell nucleus and it assembles with the
newly replicated genomes
^ the assembled viral capsid moves to the plasma membrane and buds off,
taking a segment of the membrane containing hemagluttinin and
neuraminidase, it forms a viral particle
^ viral neuraminidase enzyme clears and removes the sialic acid receptors,
from the surface of the cell, it allows the release and spread of the virus to new
cells
, M2 ION CHANNELS INHIBITORS
Mechanism of action – it blocks the M2 channels, restricting the pathway of
the protons, which is necessary to trigger the production of viral genome into
the cell nucleus
AMANTADINE
RIMANTADINE
ENDONUCLEASE INHIBITORS
Mechanism of Action – Selectively inhibiting cap dependent endonuclease, it is
necessary to initiate influenza virus MRna synthesis
It prevents the viral transcription, which, leads to,
influenza viral replication
BALOXAVIR
NEURAMINIDASE INHIBOTORS
Mechanism of action – Inhibition of neuraminidase enzyme
It becomes unable to cleave to the sialic acid and the virus is unable to escape
from the cell
OSELTAMIVIR
PERAMIVIR
ZANAMIVIR
*ANTI INFLUENZA DRUGS
influenza virus is enveloped virus, single stranded,
segmental Rnas
the viral envelope is made up of lipid bilayer,
1. Hemagluttin
2. Neuraminidase
3. Matrix 2
^ the binding of hemagluttin to Salic acid residues in the surface of the host
cell results in, engulfment of the virus into the cell, via endocytosis.
^ M2 forms pH gated channels that allows the protons to move through the
viral envelope and acidify the core of the virus, which, leads to, release of viral
Rnas and proteins, it is transported to the cell membrane.
^ in the cell nucleus, the viral Rna is transcribed into messenger Rna (MRna )
^ The MRna undergoes, translation, in the ribosomes to viral proteins
^ Once synthesized, hemagluttin, neuraminidase and glycoproteins are
secreted through the Golgi apparatus onto the cell surface where they fuse
with the plasma membrane
^ other viral proteins, migrate to the cell nucleus and it assembles with the
newly replicated genomes
^ the assembled viral capsid moves to the plasma membrane and buds off,
taking a segment of the membrane containing hemagluttinin and
neuraminidase, it forms a viral particle
^ viral neuraminidase enzyme clears and removes the sialic acid receptors,
from the surface of the cell, it allows the release and spread of the virus to new
cells
, M2 ION CHANNELS INHIBITORS
Mechanism of action – it blocks the M2 channels, restricting the pathway of
the protons, which is necessary to trigger the production of viral genome into
the cell nucleus
AMANTADINE
RIMANTADINE
ENDONUCLEASE INHIBITORS
Mechanism of Action – Selectively inhibiting cap dependent endonuclease, it is
necessary to initiate influenza virus MRna synthesis
It prevents the viral transcription, which, leads to,
influenza viral replication
BALOXAVIR
NEURAMINIDASE INHIBOTORS
Mechanism of action – Inhibition of neuraminidase enzyme
It becomes unable to cleave to the sialic acid and the virus is unable to escape
from the cell
OSELTAMIVIR
PERAMIVIR
ZANAMIVIR
