GLUCONEOGENESIS
Glucose
Gewese-6-phosphatase
Glucose-6-phosphate
12
Isomerase
-
Fructose-6-phosphate
X
Fructose-1,6-bisphosphatase
Fructose-6-bisphosphate
Glyceraldehyde-s-Phosphate QUAD
S ↑
NAD+
Glycerol-3-phosphate DN
&
2
> NAD4 +4t
unit
witin
↳ Bisphosphoglycerate Glycerol-3-phosphate
- M
AD ADP
~
AT
A
Glycera kinase
3-phosphoglycerate GLYCEROL
1
-
2-
Phosphoglycerate
-
e CYTOPLASM
>Phasphdendpyruvate
~
ADP
GDP ↳ AT
j
LDH
PEPCK
Pyrorate LACTATE
GTP ALT
Pyruvate
L ALANINE
Pyruvate MITOCHONDRIA
aboutwingeeventhe
Carbaylase v
Acetyl con
-- occaloacetate
Nien) MDH
NA1#
, synthesis of glucose from
non-carbohydratecompounds
*
<partial reversal of glycolysis)
lactate, pyruvate, fumarate, glycerol, propionate
* Location-mainly in cytosol, takes place mainly in the Liver I to some in
extent the
matrix.
kidney
* Importance: -
(a) Brain CNS, RBCs and Testes are dependanton glucose for continuous
supply of
energy
(b) Glucose that supplies energy to skeletal muscle is anaerobic conditions
is
only source
(2)
During fasting, Gluconeogenesis occur
must to meetbasal requirements
of glucose
for body.
* Significance: -
(a) Maintains blood glucose during stration.
13) Itis used to clear the waste products of metabolism.
eg:lactate from muscle and RBCs, Glycerol from adipose tissue, Propionyl CoAfrom
Boccidatich of odd chain
fatty acids.
These compounds taken up
are
by liver-undergo gluconeogenesis.
*
Regellatich:-
ENZYME INDUCER REPRESSOR ACTIVATOR INUIBITOR
Pyruvate Carboxylase Glucagon, cortisal Insuli Acetyl CoA ADP
(1 (L
PEPCK
1 Amp
LI
Fructose I, o
bisphosphatase Citale Fructose 2.6 Bis-
12
11 -
phosphatase.
Glasses
phosphatase
, CORI CYCLE
Muscle/RBL Liver
glwase glowse
glycogen -
Anaerobic
gewednedgenesis
Glycolysis
~v
lactate > lactate
significance:indirect way of utilising muscle
glycogen to maintain blood
level in conditions.
gerase fasting
Glucose
Gewese-6-phosphatase
Glucose-6-phosphate
12
Isomerase
-
Fructose-6-phosphate
X
Fructose-1,6-bisphosphatase
Fructose-6-bisphosphate
Glyceraldehyde-s-Phosphate QUAD
S ↑
NAD+
Glycerol-3-phosphate DN
&
2
> NAD4 +4t
unit
witin
↳ Bisphosphoglycerate Glycerol-3-phosphate
- M
AD ADP
~
AT
A
Glycera kinase
3-phosphoglycerate GLYCEROL
1
-
2-
Phosphoglycerate
-
e CYTOPLASM
>Phasphdendpyruvate
~
ADP
GDP ↳ AT
j
LDH
PEPCK
Pyrorate LACTATE
GTP ALT
Pyruvate
L ALANINE
Pyruvate MITOCHONDRIA
aboutwingeeventhe
Carbaylase v
Acetyl con
-- occaloacetate
Nien) MDH
NA1#
, synthesis of glucose from
non-carbohydratecompounds
*
<partial reversal of glycolysis)
lactate, pyruvate, fumarate, glycerol, propionate
* Location-mainly in cytosol, takes place mainly in the Liver I to some in
extent the
matrix.
kidney
* Importance: -
(a) Brain CNS, RBCs and Testes are dependanton glucose for continuous
supply of
energy
(b) Glucose that supplies energy to skeletal muscle is anaerobic conditions
is
only source
(2)
During fasting, Gluconeogenesis occur
must to meetbasal requirements
of glucose
for body.
* Significance: -
(a) Maintains blood glucose during stration.
13) Itis used to clear the waste products of metabolism.
eg:lactate from muscle and RBCs, Glycerol from adipose tissue, Propionyl CoAfrom
Boccidatich of odd chain
fatty acids.
These compounds taken up
are
by liver-undergo gluconeogenesis.
*
Regellatich:-
ENZYME INDUCER REPRESSOR ACTIVATOR INUIBITOR
Pyruvate Carboxylase Glucagon, cortisal Insuli Acetyl CoA ADP
(1 (L
PEPCK
1 Amp
LI
Fructose I, o
bisphosphatase Citale Fructose 2.6 Bis-
12
11 -
phosphatase.
Glasses
phosphatase
, CORI CYCLE
Muscle/RBL Liver
glwase glowse
glycogen -
Anaerobic
gewednedgenesis
Glycolysis
~v
lactate > lactate
significance:indirect way of utilising muscle
glycogen to maintain blood
level in conditions.
gerase fasting
