Chemotherapy Certification Exam Questions and answers, 100% Accurate. VERIFIED.

Chemotherapy Certification Exam Questions and answers, 100% Accurate. VERIFIED. Doxorubicin - Cardiotoxic TISSUE VESICANT Baseline MUGA and total dose (CONCERN at 550 mg/m2) URINE=RED IF EXTRAVASATION OCCURS= cool/ice + Totect Idamycin - Cardiotoxic (cardiomyopathy) Bleomycin - AVOID oxygen supplementation Methotrexate - *Leukovorin decreases cytotoxicity* Pemetrexed - Vitamin B12 & folic acid supplements to decrease toxicity Fludarabine - Immunosuppression Thioguanine - Bone Marrow Suppression Stomatitis/Mucositis 5-FU - *Stomatitis Bone marrow depression *Diarrhea Mucositis Capeticibine - ***Pro-drug that converts 5FU in liver Stomatitis & mucositis Palmar-plantar erythrodysthesias (hand foot syndrome) Cytarabine or Cytosine Arabinoside - Cerebellar neurotoxicity Gemcitabine - Radiosensitizer DO NOT GIVE W/ RADIATION, except at very low doses Carmustine - ***Solvent is alcohol Alcohol sensivity is an issue Mix ONLY in 0.9% NaCl Carboplatin - Dose by CALVERT formula Allergic reaction increased from 1-27% in pts receiving 6-7 courses Cisplatin - Renal toxicity Kidney protection w/ fluids & sometimes AMIFOSTINE MONITOR MAGNESIUM levels Oxaliplatin - NEUROTOXICITY AVOID COLD (neuropathies exacerbated by cold exposure) Dilute with D5W* Cyclophosphamide - HEMMORRAGHIC CYSTITIS Blood in urine - fluids (sometimes Mesna) Temazolamide - Headache (crosses into CNS)*** Interferons - ACUTE: Flu-like Syndrome CHRONIC: Depression- BLACK BOX WARNING Interleukin-2 - Flu-like Syndrome Capillary Leak Syndrome Cabazitaxel - No PVC bags or tubing! Docetaxel - No PVC bags or tubing! Paclitaxel - Glass or Polyolefin container. NO PVC container or tubing. 0.22 in-line filter Etoposide - Alopecia Hypotension Can cause hypotension w/ rapid infusion Monitor for hypersensitivity reactions Irinotecan - EARLY diarrhea - give atropine LATE diarrhea - give Imodium Vincristine - Neurotoxicity Peripheral Neuropathy Constipation Monitor LFTs FOR IV USE ONLY!!! FATAL IF GIVEN INTRATHERCALLY Cetuximab - Acneform rash Ipilimumab - Immune mediated S/E TX= STEROIDS Pembrolizumab - Immune mediated toxicities: Manage immune mediated toxicities with high dose steroids Rituximab - for CD20+ lymphocytes Trastuzumab - Cardiac issues Administered in HER 2+ disease Erlotinib - Rash (75% of pts) Arsenic trioxide - Serum electrolyte Mg Thalidomide - Teratogenicity BLACK BOX WARNING: DO NOT GIVE TO WOMEN WITH RISK OF PREGNANCY Hydroxyurea - Radiosensitizer Bicalutamide - MOA- blocks effects of androgens on prostate LHRH Agonists and LHRH Antagonists - ACUTE: Increases in hormones- hot flashes, osteoporosis, high cholesterol, wt gain, depression CHRONIC: effects from decreased hormone production- loss of muscle mass, cognitive changes, anemia, sexual dysfunction, gynecomastia Aromatase inhibitors- Anastrazole - Osteoporosis Give to post-menopausal women only SERMS (Tamoxifen) - Menopausal symptoms Risk of endometrial cancer Thrombosis risk Amifoxtine - Tissue protectant: nephrotoxicity & n