Chemotherapy/Immunotherapy Certificate Course (ONS, ONCC). Top Exam Questions and answers. Rated A+

Chemotherapy/Immunotherapy Certificate Course (ONS, ONCC). Top Exam Questions and answers. Rated A+ Alkylating agents - Classification Break DNA helix strand, thereby interfering with DNA replication Altretamine (Hexalen) - Alkylating Agent PO Ovarian CA Side effects- nausea, vomiting, skin rash, hypersensitivity reaction, diarrhea Dose limiting - neuro-toxicity, peripheral neuropathy, myelosuppression Bendamustine (Treanda/Bendeka) - Alkylating agent IV CLL or Indolent NHL Side effects- pyrexia, nausea, vomiting, skin reactions, TLS, hepatotoxicity, vein irritation Dose limiting - myelosuppression Irritant and vesicant properties infusion reactions likely to occur in 2nd or subsequent infusions Busulfan (IV busulfex: PO Myleran) - Alkylating Agent IV or PO CML and Stem cell prep Side effects - profound tachycardia, HTN, chest pain, hyperpigmentation, alopecia, infertility, confusion, suizures, mucositis, nausea, vomiting, insomnia, hyperglycemia, blurred vision, secondary malignancy, VOD (now sinusoidal obstruction syndrome) seizure prophylaxis central line only for IV Carboplatin - Alkylating agent IV Ovarian CA