Infectious Bursal Disease: Gumboro
Poultry Pathology(Path-611)
Lecture 8
Dr. Muhammad Kashif Saleemi
DVM, MSc(Hons.) PhD, US-NAS Fellow
Associate Professor (Tenured)
Department of Pathology, Faculty of Veterinary Science,
University of Agriculture, Faisalabad, Pakistan
,Introduction and History
◼ Infectious Bursal Disease (IBD) is an acute highly
contagious viral disease of young chicks having bursa of
Fabricius as primary target organ and immunosupression
◼ IBD was first reported in 1962 in Gumboro, Delware , USA
therefore disease is also named as Gumboro
◼ The immunosupressive role/effect of IBDV was first reported
by Allan in 1972
◼ IBD was controlled for many years with classical vaccines
prepared from early isolates
◼ In 1980 from Dalmarva USA variant serotype of IBD was
reported that is a persistent problem in Africa, Aisa, South
America, USA and Netherland (very virulent strain)
,The Town of Gumboro, Delaware in the United
States was the First Place where Gumboro
Disease was found in 1962.
, Etiology
◼ IBD is caused by double stranded RNA virus belonging to
genus Avibirnavirus and family Birnaviridae
◼ The viral genome has two double stranded RNA segments
◼ The virus can be easily propagated in chicken embryos and
cell lines
◼ Two serotypes are present but serotype 1 is pathogenic
◼ Five viral proteins are present VP1, VP2, VP3, VP4 and VP5
◼ VP3 major protein is responsible for immunosupression
◼ VP2 is essential immunogen of IBDV
◼ VP1 protein is involved in virus replication process
◼ VP5 induced apoptosis in the infected cells by IBD virus
Poultry Pathology(Path-611)
Lecture 8
Dr. Muhammad Kashif Saleemi
DVM, MSc(Hons.) PhD, US-NAS Fellow
Associate Professor (Tenured)
Department of Pathology, Faculty of Veterinary Science,
University of Agriculture, Faisalabad, Pakistan
,Introduction and History
◼ Infectious Bursal Disease (IBD) is an acute highly
contagious viral disease of young chicks having bursa of
Fabricius as primary target organ and immunosupression
◼ IBD was first reported in 1962 in Gumboro, Delware , USA
therefore disease is also named as Gumboro
◼ The immunosupressive role/effect of IBDV was first reported
by Allan in 1972
◼ IBD was controlled for many years with classical vaccines
prepared from early isolates
◼ In 1980 from Dalmarva USA variant serotype of IBD was
reported that is a persistent problem in Africa, Aisa, South
America, USA and Netherland (very virulent strain)
,The Town of Gumboro, Delaware in the United
States was the First Place where Gumboro
Disease was found in 1962.
, Etiology
◼ IBD is caused by double stranded RNA virus belonging to
genus Avibirnavirus and family Birnaviridae
◼ The viral genome has two double stranded RNA segments
◼ The virus can be easily propagated in chicken embryos and
cell lines
◼ Two serotypes are present but serotype 1 is pathogenic
◼ Five viral proteins are present VP1, VP2, VP3, VP4 and VP5
◼ VP3 major protein is responsible for immunosupression
◼ VP2 is essential immunogen of IBDV
◼ VP1 protein is involved in virus replication process
◼ VP5 induced apoptosis in the infected cells by IBD virus
