SALMONELLOSIS
Poultry Pathology (Path-611)
Lecture 20&21
Dr. Muhammad Kashif Saleemi
DVM, M.Sc (Hons.), PhD
Associate Professor (Tenured)
Member National Disease Control Committee (NDCC)
US-NAS One Health Fellowship
Head Diagnostic Laboratory Department of Pathology
Department of Pathology, Faculty of Veterinary Science,
University of Agriculture, Faisalabad, Pakistan
, Introduction and History
◼ PullorumDisease (PD)
◼ Fowl Typhoid (FT)
, Public Health Significance
◼ The pathogenesis of infection is such that in adult birds the
alimentary tract is rarely affected unless clinical disease occurs.
◼ Therefore the pathogens seldom enter the human food chain.
◼ Rare cases of PD in humans have resulted from massive
exposure following the ingestion of contaminated foods or
experimental challenge.
◼ According to a Centers for Disease Control and Prevention report
18 S. pullorum isolates and 8 S. gallinarum isolates were reported
out of a total of 458,081 Salmonella isolates from humans
between 1982 and 1992.
◼ Experimental reproduction of salmonellosis with 4 strains of S.
Pullorum in humans with large numbers (billions) of bacteria
produced only transient clinical signs followed by prompt recovery
, INTRODUCTION AND HISTORY
◼ The bacillus that causes pullorum disease was first described in
1900. Within a few years pullorum disease was recognized as a
common, worldwide, egg-borne disease of chickens.
◼ A tube agglutination test that would detect carriers was developed
in 1913 and a whole blood test was developed in 1931. These
tests permitted development of eradication programs.
◼ Losses from pullorum disease were once so severe that they
impaired expansion of the poultry industry.
◼ Pullorum disease was spread through hatchery-infected chicks.
◼ Extensive losses from Pullorum disease and fowl typhoid were
partly responsible for stimulating the development of the National
Poultry Improvement Plan in US
Poultry Pathology (Path-611)
Lecture 20&21
Dr. Muhammad Kashif Saleemi
DVM, M.Sc (Hons.), PhD
Associate Professor (Tenured)
Member National Disease Control Committee (NDCC)
US-NAS One Health Fellowship
Head Diagnostic Laboratory Department of Pathology
Department of Pathology, Faculty of Veterinary Science,
University of Agriculture, Faisalabad, Pakistan
, Introduction and History
◼ PullorumDisease (PD)
◼ Fowl Typhoid (FT)
, Public Health Significance
◼ The pathogenesis of infection is such that in adult birds the
alimentary tract is rarely affected unless clinical disease occurs.
◼ Therefore the pathogens seldom enter the human food chain.
◼ Rare cases of PD in humans have resulted from massive
exposure following the ingestion of contaminated foods or
experimental challenge.
◼ According to a Centers for Disease Control and Prevention report
18 S. pullorum isolates and 8 S. gallinarum isolates were reported
out of a total of 458,081 Salmonella isolates from humans
between 1982 and 1992.
◼ Experimental reproduction of salmonellosis with 4 strains of S.
Pullorum in humans with large numbers (billions) of bacteria
produced only transient clinical signs followed by prompt recovery
, INTRODUCTION AND HISTORY
◼ The bacillus that causes pullorum disease was first described in
1900. Within a few years pullorum disease was recognized as a
common, worldwide, egg-borne disease of chickens.
◼ A tube agglutination test that would detect carriers was developed
in 1913 and a whole blood test was developed in 1931. These
tests permitted development of eradication programs.
◼ Losses from pullorum disease were once so severe that they
impaired expansion of the poultry industry.
◼ Pullorum disease was spread through hatchery-infected chicks.
◼ Extensive losses from Pullorum disease and fowl typhoid were
partly responsible for stimulating the development of the National
Poultry Improvement Plan in US
