Cellular and Molecular Immunology 9th Edition Abbas Test Bank Latest Updates 2023 A+ GRADE.

Match each of the descriptions in questions 1-5 with the correct lettered antibody isotype (A-E). (Answers may be used more than once.) A. IgA B. IgD C. IgE D. IgG E. IgM 1. The secreted form of this isotype forms pentamers around a J chain ANS: E. IgM is secreted as a J chain–linked pentamer. 2. The most abundant Ig isotype in the blood ANS: D. The blood IgG concentration is about 3.5mg/ml and includes four subtypes (IgG1 to IgG4). 3. The isotype only found in membrane-bound form on naive B cells ANS: B. Very little IgD is secreted, and in membrane form is only on the surface of naive B cells. Its function is not well understood. 4. The isotype found predominantly in mucosal secretions ANS: A. IgA accounts for almost two thirds of the 3 g of antibody produced each day by an adult, most of which is produced in the gastrointestinal associated lymphoid tissues and secreted into the gut lumen. 5. The isotype most closely associated with immediate hypersensitivity (allergic) disease ANS: C. Most IgE that is secreted is bound to mast cells, and it plays a role in the activation of mast cells during allergic reactions. Questions 6-10 Match each description in questions 6-10 with the appropriate lettered term (A-I). A. Conformational determinant Test Bank 2 B. Linear determinant C. Neoantigenic determinant D. Hinge region E. Immun complex F. Fab G. Fc H. Tail piece I. Hapten 6. A proteolytic fragment of an antibody molecule that contains an intact antigen- binding site ANS: F. Fab fragments, derived from enzymatic cleavage of Ig molecules, are composed of one intact light chain covalently linked to the N-terminal region of one heavy chain and include a single intact antigen-binding site. 7. A three-dimensional shape, formed by a portion of a macromolecule, to which an antibody binds ANS: A. Conformational determinants will usually be destroyed by physicochemical disruption of macromolecules, such as by denaturation or proteolysis of proteins. 8. A small chemical group recognized by an antibody that is attached to a larger macromolecule