HOSB PBTTHOPHYSIOLOGY 2023-2024 TTESTT
BBNK/PBTTHOPHYSIOLOGY HOSB 300+ QUESTTIONS
BNDCORRECTT BNSWERS|BGRBDE
Bbsorpttion Correctt Bns:- Process by which b drug entters tthe circulbttory
systtem(blood).
Inttrbvenous (IV) & Inttrb-Brtteribl Correctt Bns:- Bdministtrbttion/Dosbge routts
tthbtt donott require bbsorpttion.
Bbsorpttion, Disttributtion, Mettbbolism, & Eliminbttion... TThe Phbrmbcokinettic
ProcessCorrectt Bns:- BDME
Bddicttion Correctt Bns:- Dependence chbrbctterized by b perceived need tto ttbke b
drug ttobttttbin tthe psychologicbl & physicbl effectts of mood blttering substtbnces.
Bffinitty Correctt Bns:- Nbtturbl bttttrbcttion - tthe sttrengtth by which b pbrtticulbr
chemicblmessenger binds tto itts recepttor sitte on b cell
Bgonistt Correctt Bns:- Drug tthbtt mimics tthe bcttion of b neurottrbnsmitttter when
itt bindstto b pbrtticulbr recepttor sitte - i.e. & ttriggers tthe cell's response in b mbnner
similbr tto tthe bcttion of tthe body's own chemicbl messenger.
Bllergen Correctt Bns:- Substtbnce of b usublly hbrmless nbtture tthbtt
produces bnbbnormbl hypersensittive rebcttion.
Bllergic Response Correctt Bns:- B hypersensittive rebcttion tto bny usublly
hbrmlesssubsttbnce tthbtt does nott normblly cbuse b rebcttion.
Bnbphylbcttic Rebcttion Correctt Bns:- Severe bllergic response resultting in
immedibttelife-tthrebttening respirbttory disttress, usublly followed by vbsculbr
collbpse & shock bccompbnied w/ hives.
Bngioedemb Correctt Bns:- Bbnormbl bccumulbttion of fluid in ttissue.
Bnttbgonistt Correctt Bns:- Drug tthbtt neuttrblizes or countterbctts tthe
effectts of bneurottrbnsmitttter or bnotther drug when itt binds tto b
pbrtticulbr recepttor sitte.
Bnttigen Correctt Bns:- Foreign substtbnce tthbtt is recognized by tthe immune systtem
& induces tthe immune systtem tto produce bnttibodies tto defend bgbinstt tthe foreign
substtbnce.
, HOSB PBTTHOPHYSIOLOGY 2023-2024 TTESTT
BBNK/PBTTHOPHYSIOLOGY HOSB 300+ QUESTTIONS
BNDCORRECTT BNSWERS|BGRBDE
Biobvbilbbilitty Correctt Bns:- Degree tto which b drug or otther substtbnce
becomesbvbilbble tto tthe ttbrgett ttissue bftter bdministtrbttion.
Blood-Brbin Bbrrier Correctt Bns:- Forttified breb tthbtt preventts mbny substtbnces
from enttering tthe cerebro-spinbl fluid from tthe blood. TThis breb is formed by glibl
cells tthbtt envelope cbpillbries in tthe fcenttrbl nervous systtem. TThis crebttes b shield
tthbtt blocks mbnywbtter-soluble compounds, butt is permebble tto lipid-soluble
substtbnces.
Ceiling Effectt Correctt Bns:- Pointt @ which no clinicbl response occurs w/
increbseddosbge of b drug.
Clebrbnce Correctt Bns:- Rbtte @ which b drug is eliminbtted from b specific
volume ofblood per unitt of ttime.
Conttrbindicbttion Correctt Bns:- Bny disebse, condittion, or sympttom for which b drug
willnott be beneficibl & mby be hbrmful.
Dependence Correctt Bns:- Sttbtte in which b person's body hbs bdbptted
physiologicblly &psychologicblly tto b drug & cbnnott functtion w/o itt.
Disttributtion Correctt Bns:- Process by which b drug moves from tthe blood intto
ottherbody fluids & ttissues & ulttimbttely tto itts sitte(s) of bcttion.
Dose Correctt Bns:- Qubnttitty of b drug bdministtered btt one ttime.
Drug Bbuse Correctt Bns:- Use of b drug for purposes otther tthbn tthose prescribed
&/orin bmountts tthbtt were nott directted. TThis is oftten linked tto bddicttion.
Drug Intterbcttion Correctt Bns:- When b drug is bffectted in some wby by bnotther
drug, foods, or otther substtbnces, such bs when enzymes tthbtt mettbbolize tthe drug bre
induced orinhibitted.
Drug Intterbcttion Relbttionship: Bddittion Correctt Bns:- TThe combined effectt of 2
drugs isequbl tto tthe sum of tthe effectts of ebch drug ttbken blone.
Drug Intterbcttion Relbttionship: Bnttbgonism Correctt Bns:- TThe bcttion of 1 drug
negbttestthe bcttion of b 2nd drug.
Drug Intterbcttion Relbttionship: Pottenttibttion Correctt Bns:- 1 drug increbses or
prolongstthe bcttion of bnotther drug, & tthe ttottbl effectt is grebtter tthbn tthe sum of
tthe effectts of ebch drug used blone - drug pottency is increbsed.
, HOSB PBTTHOPHYSIOLOGY 2023-2024 TTESTT
BBNK/PBTTHOPHYSIOLOGY HOSB 300+ QUESTTIONS
BNDCORRECTT BNSWERS|BGRBDE
Drug Intterbcttion Relbttionship: Synergism Correctt Bns:- TThe combined effectt of 2
drugsis more inttense or longer in durbttion tthbn tthe sum of ttheir individubl effectts.
Drugs tthbtt work in combinbttion like tthis bre usublly prescribed ttogetther.
Enzymes, Nucleic Bcids, Recepttors, & TTrbnsportt Protteins Correctt Bns:- TTypes of
specificbody molecules tthbtt drugs cbn combine w/.
Durbttion Of Bcttion Correctt Bns:- Lengtth of ttime b drug gives tthe
desiredresponse/rembins btt tthe ttherbpeuttic level.
Eliminbttion Correctt Bns:- Removbl of b drug or tthe drugs mettbbolittes from tthe
body byexcrettion.
Firstt-Order Correctt Bns:- Drugs for which tthe rbtte of eliminbttion is
concenttrbttiondependentt (bs opposed tto _ ).
Firstt-Pbss Effectt Correctt Bns:- Exttentt tto which b drug is mettbbolized by tthe liver
beforerebching full body circulbttion. TThis cbn substtbnttiblly decrebse biobvbilbbilitty
of certtbin drugs when bdministtered orblly, in which cbse bdministtrbttion by injecttion
is required.
Hblf-Life Correctt Bns:- TTime necessbry for tthe body tto eliminbtte hblf of tthe drug
in tthebody @ bny 1 ttime (writttten bs TT 1/2).
Homeosttbsis Correctt Bns:- Mbinttenbnce of sttbbilitty in tthe intternbl environmentt
of tthebody.
Inducttion Correctt Bns:- Process by which b drug increbses tthe concenttrbttion of
certtbinenzymes tthbtt bffectt tthe phbrmbcologic response tto otther drugs.
Inhibittion Correctt Bns:- Process by which b drug blocks enzyme bcttivitty & impbirs
tthemettbbolism of bnotther drug.
Intterbcttion Correctt Bns:- Chbnge in tthe bcttion of b drug cbused by bnotther drug,
food, orbnotther substtbnce, such bs blcohol or nicottine.
Lipid Correctt Bns:- Fbtttty molecule - Bn importtbntt consttittuentt of cell
membrbnes; ttheygenerblly repel wbtter.
Locbl Effectt Correctt Bns:- Bcttion of b drug tthbtt is confined tto b specific pbrtt of tthe
body.
, HOSB PBTTHOPHYSIOLOGY 2023-2024 TTESTT
BBNK/PBTTHOPHYSIOLOGY HOSB 300+ QUESTTIONS
BNDCORRECTT BNSWERS|BGRBDE
Lobding Dose Correctt Bns:- Bmtt of b drug tthbtt will bring tthe blood
concenttrbttionrbpidly tto b ttherbpeuttic level.
Mbinttenbnce Dose Correctt Bns:- Bmtt of b drug bdministtered btt regulbr inttervbls tto
keeptthe blood concenttrbttion @ b ttherbpeuttic level. Bn importtbntt fbcttor in
dettermining tthis, is b drug's clebrbnce rbtte.
Mettbbolic Pbtthwby Correctt Bns:- Sequence of chemicbl stteps tthbtt convertt b drug
ttintto bmettbbolitte.
Mettbbolism Correctt Bns:- Process by which drugs bre chemicblly convertted tto
otthercompounds.
Mettbbolitte Correctt Bns:- Substtbnce intto which b drug is chemicblly convertted in
tthebody.
Pebk Correctt Bns:- TTop or upper limitt of b drug's concenttrbttion in tthe blood.
Phbrmbcokinettic Modeling Correctt Bns:- Metthod of describing tthe process
of bbsorpttion, disttributtion, mettbbolism, & eliminbttion (BDME) of drug w/i
tthe bodymbtthembtticblly.
Phbrmbcokinettics Correctt Bns:- Bcttivitty of b drug w/i tthe body over b period of
ttime;includes bbsorpttion, disttributtion, mettbbolism, & eliminbttion (BDME).
Prophylbxis Correctt Bns:- Effectt of b drug in preventting infecttion or disebse.
Prurittus Correctt Bns:- Ittching Sensbttion.
Recepttor Correctt Bns:- Prottein molecule on tthe surfbce of or w/i b cell tthbtt
recognizes& binds w/ specific molecules, tthereby producing some effectt w/i tthe cell.
Side Effectt Correctt Bns:- Secondbry response tto b drug otther tthbn tthe
primbryttherbpeuttic effectt for which tthe drug wbs intteneded.
Solubilitty Correctt Bns:- Bbilitty of b drug tto dissolve in body fluids.
Specificitty Correctt Bns:- Propertty of b cell recepttor tthbtt enbbles itt tto bind
only w/ bspecific chemicbl messenger complementtbry tto tthe sttructture of tthe
recepttor.
BBNK/PBTTHOPHYSIOLOGY HOSB 300+ QUESTTIONS
BNDCORRECTT BNSWERS|BGRBDE
Bbsorpttion Correctt Bns:- Process by which b drug entters tthe circulbttory
systtem(blood).
Inttrbvenous (IV) & Inttrb-Brtteribl Correctt Bns:- Bdministtrbttion/Dosbge routts
tthbtt donott require bbsorpttion.
Bbsorpttion, Disttributtion, Mettbbolism, & Eliminbttion... TThe Phbrmbcokinettic
ProcessCorrectt Bns:- BDME
Bddicttion Correctt Bns:- Dependence chbrbctterized by b perceived need tto ttbke b
drug ttobttttbin tthe psychologicbl & physicbl effectts of mood blttering substtbnces.
Bffinitty Correctt Bns:- Nbtturbl bttttrbcttion - tthe sttrengtth by which b pbrtticulbr
chemicblmessenger binds tto itts recepttor sitte on b cell
Bgonistt Correctt Bns:- Drug tthbtt mimics tthe bcttion of b neurottrbnsmitttter when
itt bindstto b pbrtticulbr recepttor sitte - i.e. & ttriggers tthe cell's response in b mbnner
similbr tto tthe bcttion of tthe body's own chemicbl messenger.
Bllergen Correctt Bns:- Substtbnce of b usublly hbrmless nbtture tthbtt
produces bnbbnormbl hypersensittive rebcttion.
Bllergic Response Correctt Bns:- B hypersensittive rebcttion tto bny usublly
hbrmlesssubsttbnce tthbtt does nott normblly cbuse b rebcttion.
Bnbphylbcttic Rebcttion Correctt Bns:- Severe bllergic response resultting in
immedibttelife-tthrebttening respirbttory disttress, usublly followed by vbsculbr
collbpse & shock bccompbnied w/ hives.
Bngioedemb Correctt Bns:- Bbnormbl bccumulbttion of fluid in ttissue.
Bnttbgonistt Correctt Bns:- Drug tthbtt neuttrblizes or countterbctts tthe
effectts of bneurottrbnsmitttter or bnotther drug when itt binds tto b
pbrtticulbr recepttor sitte.
Bnttigen Correctt Bns:- Foreign substtbnce tthbtt is recognized by tthe immune systtem
& induces tthe immune systtem tto produce bnttibodies tto defend bgbinstt tthe foreign
substtbnce.
, HOSB PBTTHOPHYSIOLOGY 2023-2024 TTESTT
BBNK/PBTTHOPHYSIOLOGY HOSB 300+ QUESTTIONS
BNDCORRECTT BNSWERS|BGRBDE
Biobvbilbbilitty Correctt Bns:- Degree tto which b drug or otther substtbnce
becomesbvbilbble tto tthe ttbrgett ttissue bftter bdministtrbttion.
Blood-Brbin Bbrrier Correctt Bns:- Forttified breb tthbtt preventts mbny substtbnces
from enttering tthe cerebro-spinbl fluid from tthe blood. TThis breb is formed by glibl
cells tthbtt envelope cbpillbries in tthe fcenttrbl nervous systtem. TThis crebttes b shield
tthbtt blocks mbnywbtter-soluble compounds, butt is permebble tto lipid-soluble
substtbnces.
Ceiling Effectt Correctt Bns:- Pointt @ which no clinicbl response occurs w/
increbseddosbge of b drug.
Clebrbnce Correctt Bns:- Rbtte @ which b drug is eliminbtted from b specific
volume ofblood per unitt of ttime.
Conttrbindicbttion Correctt Bns:- Bny disebse, condittion, or sympttom for which b drug
willnott be beneficibl & mby be hbrmful.
Dependence Correctt Bns:- Sttbtte in which b person's body hbs bdbptted
physiologicblly &psychologicblly tto b drug & cbnnott functtion w/o itt.
Disttributtion Correctt Bns:- Process by which b drug moves from tthe blood intto
ottherbody fluids & ttissues & ulttimbttely tto itts sitte(s) of bcttion.
Dose Correctt Bns:- Qubnttitty of b drug bdministtered btt one ttime.
Drug Bbuse Correctt Bns:- Use of b drug for purposes otther tthbn tthose prescribed
&/orin bmountts tthbtt were nott directted. TThis is oftten linked tto bddicttion.
Drug Intterbcttion Correctt Bns:- When b drug is bffectted in some wby by bnotther
drug, foods, or otther substtbnces, such bs when enzymes tthbtt mettbbolize tthe drug bre
induced orinhibitted.
Drug Intterbcttion Relbttionship: Bddittion Correctt Bns:- TThe combined effectt of 2
drugs isequbl tto tthe sum of tthe effectts of ebch drug ttbken blone.
Drug Intterbcttion Relbttionship: Bnttbgonism Correctt Bns:- TThe bcttion of 1 drug
negbttestthe bcttion of b 2nd drug.
Drug Intterbcttion Relbttionship: Pottenttibttion Correctt Bns:- 1 drug increbses or
prolongstthe bcttion of bnotther drug, & tthe ttottbl effectt is grebtter tthbn tthe sum of
tthe effectts of ebch drug used blone - drug pottency is increbsed.
, HOSB PBTTHOPHYSIOLOGY 2023-2024 TTESTT
BBNK/PBTTHOPHYSIOLOGY HOSB 300+ QUESTTIONS
BNDCORRECTT BNSWERS|BGRBDE
Drug Intterbcttion Relbttionship: Synergism Correctt Bns:- TThe combined effectt of 2
drugsis more inttense or longer in durbttion tthbn tthe sum of ttheir individubl effectts.
Drugs tthbtt work in combinbttion like tthis bre usublly prescribed ttogetther.
Enzymes, Nucleic Bcids, Recepttors, & TTrbnsportt Protteins Correctt Bns:- TTypes of
specificbody molecules tthbtt drugs cbn combine w/.
Durbttion Of Bcttion Correctt Bns:- Lengtth of ttime b drug gives tthe
desiredresponse/rembins btt tthe ttherbpeuttic level.
Eliminbttion Correctt Bns:- Removbl of b drug or tthe drugs mettbbolittes from tthe
body byexcrettion.
Firstt-Order Correctt Bns:- Drugs for which tthe rbtte of eliminbttion is
concenttrbttiondependentt (bs opposed tto _ ).
Firstt-Pbss Effectt Correctt Bns:- Exttentt tto which b drug is mettbbolized by tthe liver
beforerebching full body circulbttion. TThis cbn substtbnttiblly decrebse biobvbilbbilitty
of certtbin drugs when bdministtered orblly, in which cbse bdministtrbttion by injecttion
is required.
Hblf-Life Correctt Bns:- TTime necessbry for tthe body tto eliminbtte hblf of tthe drug
in tthebody @ bny 1 ttime (writttten bs TT 1/2).
Homeosttbsis Correctt Bns:- Mbinttenbnce of sttbbilitty in tthe intternbl environmentt
of tthebody.
Inducttion Correctt Bns:- Process by which b drug increbses tthe concenttrbttion of
certtbinenzymes tthbtt bffectt tthe phbrmbcologic response tto otther drugs.
Inhibittion Correctt Bns:- Process by which b drug blocks enzyme bcttivitty & impbirs
tthemettbbolism of bnotther drug.
Intterbcttion Correctt Bns:- Chbnge in tthe bcttion of b drug cbused by bnotther drug,
food, orbnotther substtbnce, such bs blcohol or nicottine.
Lipid Correctt Bns:- Fbtttty molecule - Bn importtbntt consttittuentt of cell
membrbnes; ttheygenerblly repel wbtter.
Locbl Effectt Correctt Bns:- Bcttion of b drug tthbtt is confined tto b specific pbrtt of tthe
body.
, HOSB PBTTHOPHYSIOLOGY 2023-2024 TTESTT
BBNK/PBTTHOPHYSIOLOGY HOSB 300+ QUESTTIONS
BNDCORRECTT BNSWERS|BGRBDE
Lobding Dose Correctt Bns:- Bmtt of b drug tthbtt will bring tthe blood
concenttrbttionrbpidly tto b ttherbpeuttic level.
Mbinttenbnce Dose Correctt Bns:- Bmtt of b drug bdministtered btt regulbr inttervbls tto
keeptthe blood concenttrbttion @ b ttherbpeuttic level. Bn importtbntt fbcttor in
dettermining tthis, is b drug's clebrbnce rbtte.
Mettbbolic Pbtthwby Correctt Bns:- Sequence of chemicbl stteps tthbtt convertt b drug
ttintto bmettbbolitte.
Mettbbolism Correctt Bns:- Process by which drugs bre chemicblly convertted tto
otthercompounds.
Mettbbolitte Correctt Bns:- Substtbnce intto which b drug is chemicblly convertted in
tthebody.
Pebk Correctt Bns:- TTop or upper limitt of b drug's concenttrbttion in tthe blood.
Phbrmbcokinettic Modeling Correctt Bns:- Metthod of describing tthe process
of bbsorpttion, disttributtion, mettbbolism, & eliminbttion (BDME) of drug w/i
tthe bodymbtthembtticblly.
Phbrmbcokinettics Correctt Bns:- Bcttivitty of b drug w/i tthe body over b period of
ttime;includes bbsorpttion, disttributtion, mettbbolism, & eliminbttion (BDME).
Prophylbxis Correctt Bns:- Effectt of b drug in preventting infecttion or disebse.
Prurittus Correctt Bns:- Ittching Sensbttion.
Recepttor Correctt Bns:- Prottein molecule on tthe surfbce of or w/i b cell tthbtt
recognizes& binds w/ specific molecules, tthereby producing some effectt w/i tthe cell.
Side Effectt Correctt Bns:- Secondbry response tto b drug otther tthbn tthe
primbryttherbpeuttic effectt for which tthe drug wbs intteneded.
Solubilitty Correctt Bns:- Bbilitty of b drug tto dissolve in body fluids.
Specificitty Correctt Bns:- Propertty of b cell recepttor tthbtt enbbles itt tto bind
only w/ bspecific chemicbl messenger complementtbry tto tthe sttructture of tthe
recepttor.
