Bioisosterism
Definition: Functional groups or molecules that
have chemical and physical similarities producing
broadly similar biological properties.
They affect same biochemically associated system
as agonists or antagonists and thereby, produce
similar biological properties.
Classification: Bioisosteres can be classified into 2
groups i.e. classical bioisiosteres and non classical
bioisosteres.
CLASSICAL BIO ISOSTERES:
They are called so because they satisfy the
Langmuir and Grimm conditions which are:
1. The bio isosteric functional groups should
contain same number of valence electrons.
E.g. Chloride and fluoride group.
2. They should be from the same column of the
periodic table. E.g. sodium and potassium.
3. Grimm’s Hydride displacement law:
Functional groups which maintain same
number of valence electrons by hydride
Definition: Functional groups or molecules that
have chemical and physical similarities producing
broadly similar biological properties.
They affect same biochemically associated system
as agonists or antagonists and thereby, produce
similar biological properties.
Classification: Bioisosteres can be classified into 2
groups i.e. classical bioisiosteres and non classical
bioisosteres.
CLASSICAL BIO ISOSTERES:
They are called so because they satisfy the
Langmuir and Grimm conditions which are:
1. The bio isosteric functional groups should
contain same number of valence electrons.
E.g. Chloride and fluoride group.
2. They should be from the same column of the
periodic table. E.g. sodium and potassium.
3. Grimm’s Hydride displacement law:
Functional groups which maintain same
number of valence electrons by hydride
