NSCS307: Lectures 26 & 27 & Practice Exam Questions and answers, Graded A+

NSCS307: Lectures 26 & 27 & Practice Exam Questions and answers, Graded A+ what are the effects on the sensitivity of the sense of smell if there is a kinase inhibitor? - -increased; GRK would not be able to inhibit the GPCR anymore what are the effects on the sensitivity of the sense of smell if there is a drug preventing hydrolysis of GTP into G proteins? - -increased; more GTP to activate AC what are the effects on the sensitivity of the sense of smell if there is a drug that prevents the re-association of the heterotrimeric G-proteins? - -decreased; more beta-gamma subunit to activate GRK, you will eventually run out of GDP what are the effects on the sensitivity of the sense of smell if there is a GRK inhibitor? - -increased; you would stop the inhibitor what are the effects on the sensitivity of the sense of smell if there is a PDE inhibitor? - -increased; you would have more cAMP present to open more CNGC channels the glomeruli in the olfactory bulb are thought to be fundamental units of organization in the olfactory system. Why is this? What information comes into a glomerulus? - -the glomeruli are where the signals are integrated from the receptors to alert the brain there is an odor; the different firing of certain receptors comes into these What does the receptive field of an olfactory receptor cell look like? - -type and concentration of odorants that best active the receptor What is it about the cortical connections in the olfactory pathway that explains the fact that scent is often associated with memory formation and mood? - -the signal goes directly to the amygdala and hippocampus before it reaches the cortex How can a limited number of odorant receptors (~300) allow humans to detect so many different odors? - -one odor will activate many receptors and the combination of those is what the brain perceives as different scents A patient reports to her doctor that she has begun to have strange olfactory experiences. In particular, her perfumes now smell bad to her, and roses have a disgusting scent for her. The doctor asks her many questions about her recent history and learns that she has had terrible allergy attacks and has been using a potent nasal spray to get relief from congestion. From what we know about the way we detect odors, explain why this might happen. - -the nasal spray either: - killed her receptor neurons and therefore the combination of the receptors still active produce a different patter which she perceives