No
Date
CHARACTERI STIC 9 OF TUMOURS
Majority of neoplasms can be categorized base4 on
certain characeristics below :
I· Rate of growth
I Caner phenotype &
e stem cels
Clinical &&gros
aross feature
N Micro5copic features
I: Local invasion (Dieet spread)
V. Met¡stasis ( Distant pre ad)
’ RATE OF GROWTH
The tumouY cells qenerally proliferate More rapdly than
the normal cells .
Benign tumours qrow slowly and nmalinant turmours
Yapialy
The rate at which the tumour enlarges depends upon
2. main factors :
Rate of cell production, qrowth fraction & rate of
cell losS
Degree of differentialion of the tumour.
producionqrOnh fraction & rae of cell loss :
Rate of cel
upon 3 important
Rale of qronth of a tumour depends
parameters
tumour cels
i) Doubling time ofremainingin proliferative pool (qronh fracten)
Gi) Number of cels cells by cell sheddng
(üt) Rae of loss of tumour
CAMPAP
, No
Date
- Malinant tumour cells have increased mito tie rate (doubling
Hime and sloNer rate of deah,i , the. cancer cells do
not follow normal controls in cel cycde and ae imnortal.
- JF the rate of cell divislon is high, it is likely that
tumour cells in the centra of the tumour do not
receive adequate nounishment and undergo isehaemic
necrosis.
These tumor cells either lost by shedding or leare
are
the cel cycle to enter into Go (resting phase) or ai phase
e Deqree of differenti ation
The raBe of qrowth of malignant tumour is directy
proporhonal o he degree of differentiation
Poorls differentiated tumours show aqgressive growth
tumours .
patem as compared to beter. differentiated of
The requlation of tumour qrowth is under the contol
the tumour cells. These sre :
growth factors &ecre ated by
Epidemal qro wth factor (ESF)
Fibro blast growth actor (FoF)
* Platelet derived growth factor (PD6F)
Cdony stimulating factor (cSF)
Transbrmin groh factor - ¢ (TaF - c)
Inter leukins (IL)
Vas cular endotheli al qrowth factor (VEGF)
Date
CHARACTERI STIC 9 OF TUMOURS
Majority of neoplasms can be categorized base4 on
certain characeristics below :
I· Rate of growth
I Caner phenotype &
e stem cels
Clinical &&gros
aross feature
N Micro5copic features
I: Local invasion (Dieet spread)
V. Met¡stasis ( Distant pre ad)
’ RATE OF GROWTH
The tumouY cells qenerally proliferate More rapdly than
the normal cells .
Benign tumours qrow slowly and nmalinant turmours
Yapialy
The rate at which the tumour enlarges depends upon
2. main factors :
Rate of cell production, qrowth fraction & rate of
cell losS
Degree of differentialion of the tumour.
producionqrOnh fraction & rae of cell loss :
Rate of cel
upon 3 important
Rale of qronth of a tumour depends
parameters
tumour cels
i) Doubling time ofremainingin proliferative pool (qronh fracten)
Gi) Number of cels cells by cell sheddng
(üt) Rae of loss of tumour
CAMPAP
, No
Date
- Malinant tumour cells have increased mito tie rate (doubling
Hime and sloNer rate of deah,i , the. cancer cells do
not follow normal controls in cel cycde and ae imnortal.
- JF the rate of cell divislon is high, it is likely that
tumour cells in the centra of the tumour do not
receive adequate nounishment and undergo isehaemic
necrosis.
These tumor cells either lost by shedding or leare
are
the cel cycle to enter into Go (resting phase) or ai phase
e Deqree of differenti ation
The raBe of qrowth of malignant tumour is directy
proporhonal o he degree of differentiation
Poorls differentiated tumours show aqgressive growth
tumours .
patem as compared to beter. differentiated of
The requlation of tumour qrowth is under the contol
the tumour cells. These sre :
growth factors &ecre ated by
Epidemal qro wth factor (ESF)
Fibro blast growth actor (FoF)
* Platelet derived growth factor (PD6F)
Cdony stimulating factor (cSF)
Transbrmin groh factor - ¢ (TaF - c)
Inter leukins (IL)
Vas cular endotheli al qrowth factor (VEGF)
