BioChem C785 - WGU - Module 2 - all
questions graded A
Deedra's dad has Alzheimer's Disease (AD) which is caused by a change in protein structure
✔✔True
Alzheimer's disease is caused by aggregation of the Amyloid beta peptide and tangle formation
by the tau protein. What kinds of amino acids are likely to drive the formation of these protein
aggregates? ✔✔hydrophobic
After learning about Alzheimer's disease and one of the drugs used in its treatment, what other
drug design strategies could you use to offer treatment for AD? ✔✔1. Drugs that break up the
amyloid plaques
2. Drugs that block the production of amyloid beta peptide
3. drugs that inhibits the aggregation of protein structures
A substrate binds to an enzyme at a specific site is referred to as ✔✔an active site
You are in charge of designing a drug that inhibits the activity of a specific enzyme. An
important criteria for the drug selection is to ensure that the drug is directly in competition with
the original substrate when binding to the active site of the enzyme. What inhibitor would be an
ideal choice?
✔✔A competitive inhibitor
This study source was downloaded by 100000866603821 from CourseHero.com on 09-04-2023 07:41:45 GMT -05:00
https://www.coursehero.com/file/210851200/AP-11pdf/
, These factors can affect the protein folding and activity of an enzyme: ✔✔1. pH
2. Heat
3. Reducing agents
One way a cell can avoid overproduction of a molecule is by using a particular type of inhibition
in which the molecule itself acts as an inhibitor for an enzyme in its production pathway. This
type of regulation is known as feedback inhibition ✔✔True
What type of enzyme adds a phosphate to another molecule? ✔✔Kinase
What are possible effects that phosphorylation/dephosphorylation can have on the activity of an
enzyme? ✔✔1. turn the enzyme on
2. turn the enzyme off
In the enzymatic cycle, the enzyme shape is changed when substrate binds and resumes its
original shape when product is released after substrate is converted to product. ✔✔True
An enzyme increases the rate of a chemical reaction by: ✔✔decreasing the activation energy
Compared to a patient that is not on a statin medication, In a patient taking a statin medication
the concentration of cholesterol would decrease, the concentration of HMG-CoA would increase,
and the concentration of Acetoacetyle CoA would stay the same ✔✔True
This study source was downloaded by 100000866603821 from CourseHero.com on 09-04-2023 07:41:45 GMT -05:00
https://www.coursehero.com/file/210851200/AP-11pdf/
questions graded A
Deedra's dad has Alzheimer's Disease (AD) which is caused by a change in protein structure
✔✔True
Alzheimer's disease is caused by aggregation of the Amyloid beta peptide and tangle formation
by the tau protein. What kinds of amino acids are likely to drive the formation of these protein
aggregates? ✔✔hydrophobic
After learning about Alzheimer's disease and one of the drugs used in its treatment, what other
drug design strategies could you use to offer treatment for AD? ✔✔1. Drugs that break up the
amyloid plaques
2. Drugs that block the production of amyloid beta peptide
3. drugs that inhibits the aggregation of protein structures
A substrate binds to an enzyme at a specific site is referred to as ✔✔an active site
You are in charge of designing a drug that inhibits the activity of a specific enzyme. An
important criteria for the drug selection is to ensure that the drug is directly in competition with
the original substrate when binding to the active site of the enzyme. What inhibitor would be an
ideal choice?
✔✔A competitive inhibitor
This study source was downloaded by 100000866603821 from CourseHero.com on 09-04-2023 07:41:45 GMT -05:00
https://www.coursehero.com/file/210851200/AP-11pdf/
, These factors can affect the protein folding and activity of an enzyme: ✔✔1. pH
2. Heat
3. Reducing agents
One way a cell can avoid overproduction of a molecule is by using a particular type of inhibition
in which the molecule itself acts as an inhibitor for an enzyme in its production pathway. This
type of regulation is known as feedback inhibition ✔✔True
What type of enzyme adds a phosphate to another molecule? ✔✔Kinase
What are possible effects that phosphorylation/dephosphorylation can have on the activity of an
enzyme? ✔✔1. turn the enzyme on
2. turn the enzyme off
In the enzymatic cycle, the enzyme shape is changed when substrate binds and resumes its
original shape when product is released after substrate is converted to product. ✔✔True
An enzyme increases the rate of a chemical reaction by: ✔✔decreasing the activation energy
Compared to a patient that is not on a statin medication, In a patient taking a statin medication
the concentration of cholesterol would decrease, the concentration of HMG-CoA would increase,
and the concentration of Acetoacetyle CoA would stay the same ✔✔True
This study source was downloaded by 100000866603821 from CourseHero.com on 09-04-2023 07:41:45 GMT -05:00
https://www.coursehero.com/file/210851200/AP-11pdf/
