BC 368
Biochemistry of the
Cell II
Integration of
Mammalian
Metabolism
May 7, 2015
, Highlights of
Metabolism
1. ATP = universal energy currency
•expended to ensure unidirectionality of each
metabolic pathway and complete conversion to
products
coupling ATP hydrolysis to a reaction
increases K by a factor of ~108.
, Highlights of
Metabolism
1. ATP = universal energy currency
•expended to ensure unidirectionality of each
metabolic pathway and complete conversion to
products
•an important allosteric regulator
•generated by the oxidation of fuel molecules:
NADH and FADH2 shuttle electrons to the
ETC where the bulk of ATP is formed via
oxidative phosphorylation.
, 2. NADPH is the major electron
donor in reductive biosynthesis
•formed primarily via the pentose phosphate
pathway
3. Central metabolic pathways have
both anabolic and catabolic roles.
•TCA is an excellent example of an amphibolic
pathway.
Biochemistry of the
Cell II
Integration of
Mammalian
Metabolism
May 7, 2015
, Highlights of
Metabolism
1. ATP = universal energy currency
•expended to ensure unidirectionality of each
metabolic pathway and complete conversion to
products
coupling ATP hydrolysis to a reaction
increases K by a factor of ~108.
, Highlights of
Metabolism
1. ATP = universal energy currency
•expended to ensure unidirectionality of each
metabolic pathway and complete conversion to
products
•an important allosteric regulator
•generated by the oxidation of fuel molecules:
NADH and FADH2 shuttle electrons to the
ETC where the bulk of ATP is formed via
oxidative phosphorylation.
, 2. NADPH is the major electron
donor in reductive biosynthesis
•formed primarily via the pentose phosphate
pathway
3. Central metabolic pathways have
both anabolic and catabolic roles.
•TCA is an excellent example of an amphibolic
pathway.
