WGU D115 master set-Advanced
Pathophysiology for the Advanced
Practice Nurse Already Graded A+
Which type of genetic disease affects males more frequently than females? ✔✔Sex-Linked
recessive. Since males only have one X and one Y, if the affected chromosome has the illness, it
will be expressed.
In which two conditions are chromosomal abnormalities the leading known cause?
✔✔Intellectual disability and fetal miscarriage. Chromosome abnormalities are the leading
known cause of intellectual disability and fetal miscarriage.
What are three examples of prenatal diagnostic studies? ✔✔Chorionic villus sampling (CVS),
amniocentesis, and preimplantation genetic testing (PGT) are examples of prenatal diagnostic
studies and are performed in vitro. CVS is a form of genetic testing that provides genetic
information found in utero and is usually performed between weeks 11 and 14 of pregnancy. An
amniocentesis is a form of genetic testing that evaluates amniotic fluid and is usually performed
during the second trimester, between weeks 15 and 20 of pregnancy. PGT is performed on the
embryo prior to implantation.
,Which genetic disorder is characterized by the presence of a zygote having one chromosome
with a normal complement of genes and one chromosome with a missing gene? ✔✔Cri du chat
syndrome (translated as "cry of the cat") is caused by a DNA deletion. This term describes the
cry often heard from a baby affected by the syndrome. Cri du chat syndrome can present as a
microcephalic, low birth-weight baby with a piercing cry.
How can an X-linked recessive disease skip generations? ✔✔The disease can be transmitted
through female carriers.
Since females have two copies of the X chromosome, the mother may provide an unaffected X to
a daughter or son. Furthermore, a daughter may not show signs of the disease because she has
the other X (the only X the father can give to a female) to cancel it out.
Which type of risk is referred to as the ratio of the disease rate among the entire population to the
disease rate in an unexposed population? ✔✔Relative risk is a ratio of probability, not an actual
occurrence of disease.
What are the empirical risks for most multifactorial diseases based on? ✔✔Many factors from
lifestyle to genetics affect multifactorial diseases. Observation and evaluation of each case
individually provides the most thorough and accurate assessment.
,What refers to the silenced gene of a gene pair. ✔✔The imprinted gene is the silent gene of a
gene pair.
What is the primary reason that some older adults have impaired inflammation and wound
healing? ✔✔The underlying chronic illness exists.
A generalized inflammatory response seen in chronic illness depletes the body's reserves to fight
against illness.
Which cells are the body's primary defense against parasite invasion? ✔✔Eosinophils are the
body's primary defense against parasites.
What Phagocytes bacteria? ✔✔Macrophages work by eating or phagocytosing bacteria.
What is the first response to a foreign pathogen? ✔✔Helper T cells
Which characteristic is the most important determinant of immunogenicity when considering the
antigen? ✔✔Immunogenicity is primarily based on the ability to recognize something foreign.
, How are erythrocytes destroyed when mismatched blood is administered, causing an ABO
incompatibility? ✔✔The complement pathway is activated in response to blood incompatibility.
What is the hypersensitivity reaction that causes atopic dermatitis? ✔✔An immediate (type I)
hypersensitivity reaction causes atopic dermatitis.
Which four infections are considered fungal infections? ✔✔Infection with a fungus is called
mycosis and includes dermatophytes (e.g., tineas, which refers to several skin mycoses,
including ringworm and athlete's foot) and yeasts, which include candida and aspergillus.
When is the earliest after sexual transmission of HIV that lab results can detect infection?
✔✔Lab testing can detect HIV RNA 4 to 10 days after sexual transmission, whereas HIV
antibody testing may take 23 to 90 days to result in a positive test. Repeat testing may be needed
to rule out a false negative test due to testing too soon after exposure, especially if a high
likelihood of exposure is suspected.
What is a characteristic of exotoxins? ✔✔Exotoxins are released during bacterial growth.
Pathophysiology for the Advanced
Practice Nurse Already Graded A+
Which type of genetic disease affects males more frequently than females? ✔✔Sex-Linked
recessive. Since males only have one X and one Y, if the affected chromosome has the illness, it
will be expressed.
In which two conditions are chromosomal abnormalities the leading known cause?
✔✔Intellectual disability and fetal miscarriage. Chromosome abnormalities are the leading
known cause of intellectual disability and fetal miscarriage.
What are three examples of prenatal diagnostic studies? ✔✔Chorionic villus sampling (CVS),
amniocentesis, and preimplantation genetic testing (PGT) are examples of prenatal diagnostic
studies and are performed in vitro. CVS is a form of genetic testing that provides genetic
information found in utero and is usually performed between weeks 11 and 14 of pregnancy. An
amniocentesis is a form of genetic testing that evaluates amniotic fluid and is usually performed
during the second trimester, between weeks 15 and 20 of pregnancy. PGT is performed on the
embryo prior to implantation.
,Which genetic disorder is characterized by the presence of a zygote having one chromosome
with a normal complement of genes and one chromosome with a missing gene? ✔✔Cri du chat
syndrome (translated as "cry of the cat") is caused by a DNA deletion. This term describes the
cry often heard from a baby affected by the syndrome. Cri du chat syndrome can present as a
microcephalic, low birth-weight baby with a piercing cry.
How can an X-linked recessive disease skip generations? ✔✔The disease can be transmitted
through female carriers.
Since females have two copies of the X chromosome, the mother may provide an unaffected X to
a daughter or son. Furthermore, a daughter may not show signs of the disease because she has
the other X (the only X the father can give to a female) to cancel it out.
Which type of risk is referred to as the ratio of the disease rate among the entire population to the
disease rate in an unexposed population? ✔✔Relative risk is a ratio of probability, not an actual
occurrence of disease.
What are the empirical risks for most multifactorial diseases based on? ✔✔Many factors from
lifestyle to genetics affect multifactorial diseases. Observation and evaluation of each case
individually provides the most thorough and accurate assessment.
,What refers to the silenced gene of a gene pair. ✔✔The imprinted gene is the silent gene of a
gene pair.
What is the primary reason that some older adults have impaired inflammation and wound
healing? ✔✔The underlying chronic illness exists.
A generalized inflammatory response seen in chronic illness depletes the body's reserves to fight
against illness.
Which cells are the body's primary defense against parasite invasion? ✔✔Eosinophils are the
body's primary defense against parasites.
What Phagocytes bacteria? ✔✔Macrophages work by eating or phagocytosing bacteria.
What is the first response to a foreign pathogen? ✔✔Helper T cells
Which characteristic is the most important determinant of immunogenicity when considering the
antigen? ✔✔Immunogenicity is primarily based on the ability to recognize something foreign.
, How are erythrocytes destroyed when mismatched blood is administered, causing an ABO
incompatibility? ✔✔The complement pathway is activated in response to blood incompatibility.
What is the hypersensitivity reaction that causes atopic dermatitis? ✔✔An immediate (type I)
hypersensitivity reaction causes atopic dermatitis.
Which four infections are considered fungal infections? ✔✔Infection with a fungus is called
mycosis and includes dermatophytes (e.g., tineas, which refers to several skin mycoses,
including ringworm and athlete's foot) and yeasts, which include candida and aspergillus.
When is the earliest after sexual transmission of HIV that lab results can detect infection?
✔✔Lab testing can detect HIV RNA 4 to 10 days after sexual transmission, whereas HIV
antibody testing may take 23 to 90 days to result in a positive test. Repeat testing may be needed
to rule out a false negative test due to testing too soon after exposure, especially if a high
likelihood of exposure is suspected.
What is a characteristic of exotoxins? ✔✔Exotoxins are released during bacterial growth.
