Walden 6630 Psychopharmacology
Midterm Study Guide
Serotonin regulates - answers Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from
reuptake of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic
5HT2 receptors - answers SSRIs
First line therapy for MDD due to milder side effect profiles - answers SSRIs
Six Common SSRIs - answers citalopram, escitalopram, fluoxetine, fluvoxamine,
sertraline, paroxetine
Onset of therapeutic benefit from SSRIs - answers 4-6 weeks
In addition to MDD, SSRIs also treat - answers Chronic Anxiety, PTSD, OCD, and
eating disorders (bulimia)
Five Common side effects of SSRIs include - answers Anxiety, insomnia, GI distress,
sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old - answers
suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination with
other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - answers Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous system -
answers Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - answers Flushing, hyperthermia, agitation,
muscle rigidity, seizure, coma, HYPERreflexia
, The treatment for serotonin syndrome - answers Cyproheptadine (5-HT2 receptor
antagonist)
Cyproheptadine treats serotonin syndrome by - answers blocking 5-HT2 receptors
(serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include -
answers Irritability, headaches, and insomnia
Medicine specific side effect of citalopram - answers Prolonged QT interval
(normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects -
answers Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - answers C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - answers fluoxetine,
fluvoxamine, and paroxetine
Five common SNRIs include - answers duloxetine, venlafaxine, desvenlafaxine,
milnacipran, levomilnacipran
This antidepressant class of medications works by binding to presynaptic SERT and
NET to inhibit them from reuptake of serotonin and norepinephrine to increase their
levels in the synaptic cleft - answers SNRIs
In addition to MDD SNRIs treat - answers Anxiety and neuropathic pain (peripheral
neuropathy)
Medication specific indications of duloxetine: - answers urinary incontinence and
Fibromyalgia
Medication specific indications of venlafaxine: - answers social anxiety, panic disorders,
PTSD, OCD, postmenopausal hot flashes
Six common side effects of SNRIs include: - answers Insomnia, nausea, sexual
dysfunction, hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old: - answers
suicidal ideation
Life threatening adverse effect of SNRIs, especially when used in combination with
other serotonergic drugs: - answers Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes: - answers venlafaxine
Midterm Study Guide
Serotonin regulates - answers Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from
reuptake of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic
5HT2 receptors - answers SSRIs
First line therapy for MDD due to milder side effect profiles - answers SSRIs
Six Common SSRIs - answers citalopram, escitalopram, fluoxetine, fluvoxamine,
sertraline, paroxetine
Onset of therapeutic benefit from SSRIs - answers 4-6 weeks
In addition to MDD, SSRIs also treat - answers Chronic Anxiety, PTSD, OCD, and
eating disorders (bulimia)
Five Common side effects of SSRIs include - answers Anxiety, insomnia, GI distress,
sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old - answers
suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination with
other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - answers Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous system -
answers Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - answers Flushing, hyperthermia, agitation,
muscle rigidity, seizure, coma, HYPERreflexia
, The treatment for serotonin syndrome - answers Cyproheptadine (5-HT2 receptor
antagonist)
Cyproheptadine treats serotonin syndrome by - answers blocking 5-HT2 receptors
(serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include -
answers Irritability, headaches, and insomnia
Medicine specific side effect of citalopram - answers Prolonged QT interval
(normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects -
answers Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - answers C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - answers fluoxetine,
fluvoxamine, and paroxetine
Five common SNRIs include - answers duloxetine, venlafaxine, desvenlafaxine,
milnacipran, levomilnacipran
This antidepressant class of medications works by binding to presynaptic SERT and
NET to inhibit them from reuptake of serotonin and norepinephrine to increase their
levels in the synaptic cleft - answers SNRIs
In addition to MDD SNRIs treat - answers Anxiety and neuropathic pain (peripheral
neuropathy)
Medication specific indications of duloxetine: - answers urinary incontinence and
Fibromyalgia
Medication specific indications of venlafaxine: - answers social anxiety, panic disorders,
PTSD, OCD, postmenopausal hot flashes
Six common side effects of SNRIs include: - answers Insomnia, nausea, sexual
dysfunction, hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old: - answers
suicidal ideation
Life threatening adverse effect of SNRIs, especially when used in combination with
other serotonergic drugs: - answers Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes: - answers venlafaxine
