Scored A+
An individual goes to bed around 8 pm and doesn't wake up until 9 am the next
morning . During this time, which of the following is the primary oxidizable
substrate in the skeletal muscle?
Free fatty acids
The process of ketogenesis refers to the conversion of acetyl CoA to which of the
following compounds?
D-3-hydroxybutyrate or beta hydroxybutyrate
Under fasting conditions, elevated glucagon will activate which of the following
enzymes?
Hormone sensitive lipase
In the fasted state, fatty acyl CoAs are transported across the mitochondrial
membrane. The transport of fatty acids via CPT1 can be directly inhibited by
which of the following compounds?
Malonyl CoA
In liver, which of the following key inhibitory events ensures that newly
synthesized palmitoyl CoA is not immediately oxidized?
Inhibition of CPT1 by malonyl CoA
During the fasted state, lipolysis is facilitated by the action of hormone sensitive
lipase. This enzyme requires which of the following modifications for activation?
phosphorylation
Which of the following is NOT a product of beta oxidation?
NADPH
A 12 year old male is brought to his primary care physician. His parents are
concerned with his recent decline in school work due to persistent blurred vision.
On physical exam, planar xanthomas are noted and laboratory testing reveals
extremely low plasma HDL. The presentation would be consistent with the LOSS
of which of the following apoproteins?
ApoA
A 16 year old woman presents to her pcp for a f/u visit. At her initial visit, 3 mo
ago, her serum cholesterol was 255 mg/dL (above normal). Today her serum
triglycerides are reported to be 260 mg/dL (above normal). She finds this very
disappointing as she started a strict dietary regimen reducing all fats and
cholesterol, replacing them with a high carb diet. You tell her that high carb diets
can increase serum triglyceride levels in some individuals. This can be attributed
to an increase in the synthesis of which of the following lipoproteins?
VLDL
Nascent chylomicrons are synthesized in which of the following organs?
Intestine
Which of the following is the major source of extracellular cholesterol for human
tissues?
LDLs