UNE Biochemistry Unit 3
Which of the following lipoproteins distributes dietary lipids?
chylomicron
The interaction of chylomicrons with lipoprotein lipase is stimulated by which of
the following Apo proteins?
ApoC II
Nascent chylomicrons are synthesized in which tissue?
Intestine
Bile salts are synthesized from cholesterol and are used for the emulsification of
dietary lipids. What is the primary fate of bile salts during digestion?
They are reabsorbed in the ileum
Nascent chylomicrons interact with HDL particles and obtain which of the
following Apo protiens?
ApoCII and ApoE
The activity of pancreatic lipase is inhibited by which of the following
compounds?
Bile salts
Which of the following statements regarding lipid digestion and absorption is
true?
A. The products of lipid digestion travel in the circulatory system in the form of
micelles.
B. The products of lipid digestion diffuse into capillaries in the vicinity of the
intestinal epithelium.
C. Pancreatic lipase emulsifies lipids.
D. The products of lipid digestion are resynthesized into triacylglycerols in
intestinal epithelial cells.
E. In the absence of bile salts, no digestion of lipids would occur.
The products of lipid digestion are resynthesized into triacylglycerols in intestinal
epithelial cells.
Under fasting conditions (Ratio of insulin to glucagon <1), elevated glucagon will
activate which of the following enzymes?
Hormone sensitive lipase
VLDL particles are characterized by which of the following apoproteins?
Apo B 100
An increase in insulin leads to which of the following metabolic shifts?
Acetyl CoA carboxylase will become dephosphorylated and active
Biotin is a cofactor required for which of the following enzymes?
A and B (Acetyl CoA carboxylase and Pyruvate carboxylase)
The first step in fatty acid synthesis is the formation of ________ from acetyl CoA
and carbon dioxide.
,malonyl CoA
Insulin increases the activity of all of the following enzymes except:
Hormone sensitive lipase
Which of the following is the regulatory enzyme for fatty acid synthesis?
AcetylCo A carboxylase
Which of the following is the regulated step of fatty acid synthesis in eukaryotes?
A. Carboxylation of acetyl CoA
B. Transportation of mitochondrial acetyl CoA into the cytosol
C. Assembly of the fatty acid chain
D. All of the above
Carboxylation of acetyl CoA
Under conditions of starvation, all of the following are true except:
A. the brain will preferentially be oxidizing ketones
B. hormone sensitive lipase will be phosphorylated
C. AMP kinase will be active
D. Malonyl CoA will be elevated
Malonyl CoA will be elevated
Which of the following proteins is responsible for the transfer of ApoB48 to
nascent chylomicrons before secretion into circulation?
Microsomal transfer protein (MTP)
The process of β-oxidation generates all of the following compounds except:
A. Acetyl CoA
B. NADPH
C. NADH
D. FADH2
NADPH
During the fasted state, lipolysis is facilitated by the action of hormone sensitive
lipase. This enzyme requires which of the following post - translational
modification for activation?
Phosphorylation
Adiponectin is secreted from adipocytes. One of the primary roles of adiponectin
is to activate AMPK in skeletal muscle which enhances the activity of which of the
following pathways?
, β oxidation
When the processes of glucose oxidation is elevated, the acetyl CoA produced
will allosterically activate which of the following enzymes leading to an increase
in the production of oxaloacetate?
Pyruvate carboxylase
The process of ketogenesis refers to the conversion of acetyl CoA to which of the
following compounds?
β-hydroxybutyrate
The transport of newly synthesized fatty acids to the adipose requires all of the
following except:
A. Interaction of ApoCII with lipoprotein lipase
B. Transport of triacylglycerols from the liver using VLDLs
C. Synthesis of triacylglycerol using glycerol 3-phosphate
D. Carnitine to shuttle the fatty acids out of the mitochondria
Carnitine to shuttle the fatty acids out of the mitochondria
In the case of a deficiency of biotin, which of the following enzymes required for
fatty acid synthesis will be impaired?
Acetyl CoA carboxylase
Which of the following compounds is the substrate for the synthesis of coritsol?
A. Cholesterol
B. Free fatty acids
C. Glucose
D. Amino acids
Cholesterol
Under cellular conditions when cholesterol is low, which of the following is a true
statement regarding the sterol response element binding protein ?
It will be associated with the the sterol response element (SRE) in the DNA
HDL particles are characterized by the presence of which apoprotein:
A. Apo B 100
B. Apo B48
C. ApoA
D. ApoCII
ApoA
Which of the following lipoproteins distributes dietary lipids?
chylomicron
The interaction of chylomicrons with lipoprotein lipase is stimulated by which of
the following Apo proteins?
ApoC II
Nascent chylomicrons are synthesized in which tissue?
Intestine
Bile salts are synthesized from cholesterol and are used for the emulsification of
dietary lipids. What is the primary fate of bile salts during digestion?
They are reabsorbed in the ileum
Nascent chylomicrons interact with HDL particles and obtain which of the
following Apo protiens?
ApoCII and ApoE
The activity of pancreatic lipase is inhibited by which of the following
compounds?
Bile salts
Which of the following statements regarding lipid digestion and absorption is
true?
A. The products of lipid digestion travel in the circulatory system in the form of
micelles.
B. The products of lipid digestion diffuse into capillaries in the vicinity of the
intestinal epithelium.
C. Pancreatic lipase emulsifies lipids.
D. The products of lipid digestion are resynthesized into triacylglycerols in
intestinal epithelial cells.
E. In the absence of bile salts, no digestion of lipids would occur.
The products of lipid digestion are resynthesized into triacylglycerols in intestinal
epithelial cells.
Under fasting conditions (Ratio of insulin to glucagon <1), elevated glucagon will
activate which of the following enzymes?
Hormone sensitive lipase
VLDL particles are characterized by which of the following apoproteins?
Apo B 100
An increase in insulin leads to which of the following metabolic shifts?
Acetyl CoA carboxylase will become dephosphorylated and active
Biotin is a cofactor required for which of the following enzymes?
A and B (Acetyl CoA carboxylase and Pyruvate carboxylase)
The first step in fatty acid synthesis is the formation of ________ from acetyl CoA
and carbon dioxide.
,malonyl CoA
Insulin increases the activity of all of the following enzymes except:
Hormone sensitive lipase
Which of the following is the regulatory enzyme for fatty acid synthesis?
AcetylCo A carboxylase
Which of the following is the regulated step of fatty acid synthesis in eukaryotes?
A. Carboxylation of acetyl CoA
B. Transportation of mitochondrial acetyl CoA into the cytosol
C. Assembly of the fatty acid chain
D. All of the above
Carboxylation of acetyl CoA
Under conditions of starvation, all of the following are true except:
A. the brain will preferentially be oxidizing ketones
B. hormone sensitive lipase will be phosphorylated
C. AMP kinase will be active
D. Malonyl CoA will be elevated
Malonyl CoA will be elevated
Which of the following proteins is responsible for the transfer of ApoB48 to
nascent chylomicrons before secretion into circulation?
Microsomal transfer protein (MTP)
The process of β-oxidation generates all of the following compounds except:
A. Acetyl CoA
B. NADPH
C. NADH
D. FADH2
NADPH
During the fasted state, lipolysis is facilitated by the action of hormone sensitive
lipase. This enzyme requires which of the following post - translational
modification for activation?
Phosphorylation
Adiponectin is secreted from adipocytes. One of the primary roles of adiponectin
is to activate AMPK in skeletal muscle which enhances the activity of which of the
following pathways?
, β oxidation
When the processes of glucose oxidation is elevated, the acetyl CoA produced
will allosterically activate which of the following enzymes leading to an increase
in the production of oxaloacetate?
Pyruvate carboxylase
The process of ketogenesis refers to the conversion of acetyl CoA to which of the
following compounds?
β-hydroxybutyrate
The transport of newly synthesized fatty acids to the adipose requires all of the
following except:
A. Interaction of ApoCII with lipoprotein lipase
B. Transport of triacylglycerols from the liver using VLDLs
C. Synthesis of triacylglycerol using glycerol 3-phosphate
D. Carnitine to shuttle the fatty acids out of the mitochondria
Carnitine to shuttle the fatty acids out of the mitochondria
In the case of a deficiency of biotin, which of the following enzymes required for
fatty acid synthesis will be impaired?
Acetyl CoA carboxylase
Which of the following compounds is the substrate for the synthesis of coritsol?
A. Cholesterol
B. Free fatty acids
C. Glucose
D. Amino acids
Cholesterol
Under cellular conditions when cholesterol is low, which of the following is a true
statement regarding the sterol response element binding protein ?
It will be associated with the the sterol response element (SRE) in the DNA
HDL particles are characterized by the presence of which apoprotein:
A. Apo B 100
B. Apo B48
C. ApoA
D. ApoCII
ApoA
