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PMNHP QUESTIONS AND ANSWER ALREADY PASSED

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HLA-B 1502 - check for prior to starting carbamazepine o asia patient, FDA required. Increased risk of SJS in pts with the allele Medication that can induce Mania: - Steroids, Antidepressants in bipolar, isoniazid, disulfiram- antabase Medication that can induce depression - Beta blockers Benzos Antineoplastic drugs, accutane Steroids Interferon Some retroviral drugs Progesterone Inhibitors - lower dose of medication - Buproprion Clomipramine - tricyclic Clarithromycin Flouroquinolones - levofloxin, cipro, moxifloxin, ofloxacin Grapefruit jice Ketoconazole - NIzoral, antifungal Nefazondome MAOI SSRI - Fluoxetine, Paroxetine Sx of lithium toxicity - N/V/D, altered mental status, oliguria, ataxia, coarse tremor, arrhythmias, T-wave flattening EPS: Dystonia - Can be within hours, muscle stiffness, involuntary movements and tics Give Cogentin, Benadryl

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PMNHP QUESTIONS AND ANSWER
ALREADY PASSED
HLA-B 1502 - ✔✔check for prior to starting carbamazepine o asia patient, FDA required. Increased
risk of SJS in pts with the allele



Medication that can induce Mania: - ✔✔Steroids, Antidepressants in bipolar, isoniazid, disulfiram-
antabase



Medication that can induce depression - ✔✔Beta blockers

Benzos

Antineoplastic drugs, accutane

Steroids

Interferon

Some retroviral drugs

Progesterone



Inhibitors - lower dose of medication - ✔✔Buproprion

Clomipramine - tricyclic

Clarithromycin

Flouroquinolones - levofloxin, cipro, moxifloxin, ofloxacin

Grapefruit jice

Ketoconazole - NIzoral, antifungal

Nefazondome MAOI

SSRI - Fluoxetine, Paroxetine



Sx of lithium toxicity - ✔✔N/V/D, altered mental status, oliguria, ataxia, coarse tremor, arrhythmias,
T-wave flattening



EPS: Dystonia - ✔✔Can be within hours, muscle stiffness, involuntary movements and tics

Give Cogentin, Benadryl
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