Proton pump
INC Syllabus inhibitors
Antiemetics
Emetics
Purgatives
Composition, Action, Dosage, Route.
Antacids Indications, Contraindications, Drug
Cholinergic < Interactions, Side effects, Adverse
Anticholinergics effects. Toxicity & Role of nurse
Fluid and Electrolyte therapy
Antidiarrheals
Histamines
,Antiemetics
•Antiemetics are the Drugs which
prevent or control the
Vomiting/Nausea.
, Classification
Ondansetron
Granisetron 5HT3 Antagonists
Dolasetron
Domperidone
Prokinetics / Dopamine Antagonists
Olanzapine
Metoclopramide
Cyclizine
Diphenhydramine
Mcclozinc Antihistamines
Promethazine
Hydroxyzine
Hyoscine & Dicyclomine Anticholinergics
, Mechanism of action
• 5HT3 Antagonists: They block serotonin receptors in CNS and
Gastrointestinal tract So they can be used to treat post operative and
cytotoxic (Chemotherapy) drugs nausea? vomiting.
• Prokinetics (Dopamine Antagonists): They block the dopamine
neurotransmitter also they promote gastrointestinal motility &
quicken gastric emptying.
• Antihistamines: They block the histamine neurotransmitter and
they act by an effect on vomiting center and by producing sedation,
• Anticholinergics: An Anticholinergic agents block the
neurotransmitter Acetyl choline in central and peripheral nervous
system.
INC Syllabus inhibitors
Antiemetics
Emetics
Purgatives
Composition, Action, Dosage, Route.
Antacids Indications, Contraindications, Drug
Cholinergic < Interactions, Side effects, Adverse
Anticholinergics effects. Toxicity & Role of nurse
Fluid and Electrolyte therapy
Antidiarrheals
Histamines
,Antiemetics
•Antiemetics are the Drugs which
prevent or control the
Vomiting/Nausea.
, Classification
Ondansetron
Granisetron 5HT3 Antagonists
Dolasetron
Domperidone
Prokinetics / Dopamine Antagonists
Olanzapine
Metoclopramide
Cyclizine
Diphenhydramine
Mcclozinc Antihistamines
Promethazine
Hydroxyzine
Hyoscine & Dicyclomine Anticholinergics
, Mechanism of action
• 5HT3 Antagonists: They block serotonin receptors in CNS and
Gastrointestinal tract So they can be used to treat post operative and
cytotoxic (Chemotherapy) drugs nausea? vomiting.
• Prokinetics (Dopamine Antagonists): They block the dopamine
neurotransmitter also they promote gastrointestinal motility &
quicken gastric emptying.
• Antihistamines: They block the histamine neurotransmitter and
they act by an effect on vomiting center and by producing sedation,
• Anticholinergics: An Anticholinergic agents block the
neurotransmitter Acetyl choline in central and peripheral nervous
system.
