NU665 paraphilic and metabolic
syndrome
pulsatile release pattern - Answers release of extended release drugs I.e. stimulants
false sense of security-still able to be misused I.e. stimulants
how do you resensitize drug receptors for pleasurable effects? - Answers substance needs to be
withdrawn-leads to cravings
when are nicotinic receptors desensitized - Answers time that one cigarette is finished
resensitized in ~45 mins
most commonly abused substances (in order)
most commonly USED substance - Answers alcohol-tobacco-MJ (in that order)
caffeine
onset of caffeine w/d sx
peak
resolution - Answers 12-24 hrs
peak 24-48 hrs
resolution 1 week
nicotine w/d sx onset
peak
duration - Answers onset 2 hrs
peak 24-48 hrs
last weeks-months
, ETOH w/d
early onset
later onset - Answers 6 hrs of significant drop in BAC
early 6-24 hrs
late 10-72 hrs
adverse effects of cannabis Carlat - Answers "makes you feel great until it doesn't"
hallucinations, anxiety, tachycardia, sleepiness, impaired memory/problem solving
heavy use unmask psychotic d/o earlier than it would have otherwise occurred
how long can impaired motor skills and slow rxn time last after acute cannabis use? - Answers 8-12 hrs
chronic cannbis use can mimic - Answers ADHD
ANXIETY
DEPRESSION
Cannabis w/d onset and duration - Answers 3-14 days last use lasts a week or less
what percent of people w/ OUD have another psychiatric d/o? - Answers 90%
what percent of people with OUD will attempt suicide at least once? - Answers 15%
fatal withdrawals - Answers ETOH
BZDs
heroine w/d onset and peak
methadone w/d onset and peak - Answers 1. 6-8 hrs, 2-3 days, resolves 7-10 days
2. 1-3 days, lasts 10-14 days
syndrome
pulsatile release pattern - Answers release of extended release drugs I.e. stimulants
false sense of security-still able to be misused I.e. stimulants
how do you resensitize drug receptors for pleasurable effects? - Answers substance needs to be
withdrawn-leads to cravings
when are nicotinic receptors desensitized - Answers time that one cigarette is finished
resensitized in ~45 mins
most commonly abused substances (in order)
most commonly USED substance - Answers alcohol-tobacco-MJ (in that order)
caffeine
onset of caffeine w/d sx
peak
resolution - Answers 12-24 hrs
peak 24-48 hrs
resolution 1 week
nicotine w/d sx onset
peak
duration - Answers onset 2 hrs
peak 24-48 hrs
last weeks-months
, ETOH w/d
early onset
later onset - Answers 6 hrs of significant drop in BAC
early 6-24 hrs
late 10-72 hrs
adverse effects of cannabis Carlat - Answers "makes you feel great until it doesn't"
hallucinations, anxiety, tachycardia, sleepiness, impaired memory/problem solving
heavy use unmask psychotic d/o earlier than it would have otherwise occurred
how long can impaired motor skills and slow rxn time last after acute cannabis use? - Answers 8-12 hrs
chronic cannbis use can mimic - Answers ADHD
ANXIETY
DEPRESSION
Cannabis w/d onset and duration - Answers 3-14 days last use lasts a week or less
what percent of people w/ OUD have another psychiatric d/o? - Answers 90%
what percent of people with OUD will attempt suicide at least once? - Answers 15%
fatal withdrawals - Answers ETOH
BZDs
heroine w/d onset and peak
methadone w/d onset and peak - Answers 1. 6-8 hrs, 2-3 days, resolves 7-10 days
2. 1-3 days, lasts 10-14 days
