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Summary Final year MD notes - renal/ nephrology

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A collection suite of final medicine MD notes to ace your penultimate and final year exams! Look no further and save the stress of accessing multiple resources as this PDF collates and summarises information from several resources including but not limited to: -Talley and O’Connor clinical examinations -OSCE revision resources online (inc. AMBOSS, AMSA, OSCEstop etc.) -RACGP guidelines -Lecture notes It is NOT intended and should NOT be used as a resource, guideline or reference for clinical practice or decision making. The resources provided should not be utilised and applied to patients looking for medical information or advice. If any of the information presented seems slightly questionable, please consult your senior colleagues, guidelines, research papers or personal doctor for further info.

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RENAL MEDICINE H+E:

How often? How much – polyuria ® oliguria (<400mL)® anuria (<40mL) ? [possible UTI]
F requency • Small void – BPH?
• Clear urine = Renal failure?
U rgency • Sudden/gradual urge? è (stress, urge, overflow incontinence)
N octuria Excessive urination at night è benign prostatic hyperplasia (BPH)
Any pain when urinating? è Flank / Back Pain? è Does it radiate? [renal colic – STONES?]
• Infection?
D ysuria
• Pain syndrome?
• Storage/trigonal/ureteric pathology?
W eak stream Does it flow out slowly? è (hesitancy)
I ntermittency Flow that stops and starts
S training/Strangury “Do you need to strain to urinate?” (prostate issue) | Or strangury = bloody urine + dysuria
E mptying incomplete Dribbling è Pis-en-deux ® double-voiding (incomplete bladder emptying)
• Smell & Colour (Heamaturia, pale, dark yellow),
Quality • Consistency (foamy = proteinemia | microscopic deposits in urine = casts )
1. History of (e.g. RBC casts/clumps = haemorrhage , WBC casts = infection/inflammation)
presenting Fever • Night Sweats [clear differential that it is NOT CKD] è UTI or stones
complaint
• Protective sex | Libido | Vaginal/Penile Discharge | Genital rash
Common
[FUNDWISE-QFS] • Infertility | Urethral discharge (STIs)
[PORN HAWCS] • Pre-ejaculation |Erectile dysfunction (Full Erection) è diabetes or HF
Men
• Retrograde ejaculation
Sexual Health • # of Pregnancies | Orgasm (MS?, spinal cord disease)
• LAST menses cycle (regularity – 28-35 days)
• Oligomenorrhea (regular menses)
Women
• Amenorrhea (primary = menopause or ovarian failure, Oral contraceptives)
• Menorrhagia (heavy menstrual flow)
• Dysmenorrhea (pain with menstruation)

General symptom screen especially for CKD (eGFR < 60 mL/min/1.73m2):
• Hiccups | Anorexia (reduced appetite + metallic taste)
• Pruritus
(accumulation of ureamic toxins)
• Oliguria (< 400mL = LATE stage CKD)
• Weight gain/loss (Unexplained)
• REST è insomnia | Fatigue/lethargy
• Confusion
Malaise (discomfort)
• Swelling/Oedema (weight gain) è extremity swelling, pleural
• Nausea & Vomiting
effusions, pulmonary oedema èexertional SOB
(accumulation of ureamic toxins)
• polydipsia (excessive thirst)
Kidneys Ureter Bladder Prostate Urethra/Gynae/Teste
• Sepsis • Sepsis • Sepsis • Sepsis • Sepsis
• Loin-groin pain • Loin-groin pain • Cystitis [FUND] • Cystitis [FUND] • Obstruction [WISE]
2. Organ Focus
• Heamaturia • Heamaturia • Incontinence • Incontinence • Mass
(kidneys, ureter,
bladder, genitals, • Heamaturia • Obstruction [WISE] • Burning/pain at tip
urethra) • Vitals, febrile • Vitals, febrile • Vitals, febrile • Vitals, febrile • Vitals, febrile
• Ballotable • +ve dipstick • Palpate Bladder • Percuss Bladder • Pelvic exam (Females)
kidney • +ve dipstick • DRE (size, tender) • Testicular mass
• +ve dipstick
• Conditions = Previous UTI | diabetes (gestational, obese) è hypoglycemic episodes | HT | Gout |Enuresis
3. Past MHx • Medications:
[CHOMV STAVE] 1. oral hypoglycemics | PDE5i (Viagra) = erectile dysfunction
“compliance about 2. Nephrotoxins: IV contrasts (lithium), NSAIDs (aspirin) | Alpha-blockers (prostatic enlargement)
medication?” 3. Diuretics è adds to nocturia / incontinence / stones | Antibiotics (UTI prophylaxis + strep infections)
4. ACEi/ARBs è elevated creatinine
• Home life/accommodation + family support (esp. prostate cancer predisposes children)
• Independence: mobility care/needs [CKD patients have social problems – How are you coping?]
4. Social Hx
• Lifestyle + Hobbies è DIET + EXERCISE (Esp. dietician advice)
[SHIELDOM]
• Alcohol (CAGE questions) | Smoking (pack years) + when did they quit |
• Drugs (opioids, benzodiazepines, hallucinogens, cannabinoids – how long, how administered)
5. Family Hx • FHx of renal disease: Autosomal dominant polycystic kidney disease or glomerulonphritidies (e.g. IgA neuropathy)
“important for young child • Family Hx of CV risk factors (e.g. diabetes and HT)
with diabetes” • Family Hx of deafness and renal impairment (Alport’s syndrome è inherited nephritis)

Biochemical examination [DIPSTICK]
Urinalysis Indication Interpretation
Colour Heamaturia
Turbidity Proteinuria or bacteria

pH acidity of urine
↓pH in systemic acidosis = More suggestive of HC
infection
amount of solute
Specific gravity ↓ in DI, polydipsia
dissolved in
Blood RBC in urine Infection, inflammation, cancer, obstruction?
Protein level of protein in the urine ↑ nephrotic syndrome
• High sensitivity ATN CKD
Leukocyte enzyme produced by • low specificity for infection as can be
esterase neutrophils due to STI, renal calculi, IDC, recent
surgery, chemo
• Higher specificity (more likely to be MICROSCOPIC examination of Urine sediments (RBC, WBC, bacteria, casts)
breakdown products
infection) Feature Indication
Nitrites caused by
Gram -ve organisms • low sensitivity as some bacteria do not RBC haematuria, haemoglobinuria or myoglobinuria
produce nitrites confirmed by + positive leukocyte esterase)
WBC
breakdown product of UTI or urinary tract inflammation
Ketones ↑ starvation / ↑DKA
fatty acid metabolism • cylindrical structures formed in the lumen of renal
Glucose ↑ hyperglycaemia poorly controlled diabetes tubules and collecting ducts by precipitation of
Casts
mucoproteins secreted by cells in the kidney
Bilirubin ↑ conjugated bilirubin ↑ biliary tract obstruction • WAXY CASTS = CKD
Urobilinogen ↑ bilirubin turnover ↑haemolytic anaemia

, Urological Key Features
Diseases = Possible causes [VITAMINS D]
• V= vascular issues Failure Type Description
• I = Infection/inflammation
rapid severe loss in renal function è waste
• T = traumatic causes • Acute (AKI)
accumulation + oliguria
• A = auto-immune conditions
• M = malignant tumour (or benign) • Chronic Persistent > 3 months
• I = iatrogenic (caused by physician/surgery)
• N/M = Neoplasms or metabolic abnormality • Acute on Worsening of kidney function when patient has CKD
• S = Stones + strictures/stenosis +cysts chronic
• D = Drugs



Urine Issue
• Urological: cystitis, urethritis, pyelonephritis, BPH
Dysuria
• Other: anxiety, prostatitis, pregnancy, bladder or lower urethral calculi, drugs (e.g. diuretics)
• Endocrine: (T2DM, diabetes insipidus, cushings)
Polyuria
• Urological: CKD, UTI,
Oliguria (<400mL/day)/ • Late stage CKD, urethral stricture, BPH, UTI (+ dysuria), bladder neck obstruction (i.e. tumour, calculi)
Anuria (<50mL/day) • Other: Phimosis, MS, SCI, anticholinergic drugs, constipation (common), SIADH



Colour of urine Underlying cause
• overhydration, recent colourless excessive beer consumption,
Very pale/colourless
• diabetes insipidus,* post-obstructive diuresis
• Concentrated urine (e.g. dehydration), Bilirubin
Yellow-orange
• Drugs: Tetracycline, anthracene, sulfasalazine, riboflavin, rifampacin
Brown • Brown Bilirubin, Nitrofurantoin, phenothiazines; chloroquine, senna, rhubarb (yellow to brown or red)
• Beetroot consumption
Pink
• Drugs” Phenindione, phenolphthalein (laxatives),
• bladder transitional cell carcinoma (painless hamaturia)
• renal cell carcinoma | urethral trauma (e.g. catheter) | UTI | Urethitis
Red / heamaturia
• Other Urological: glomerulonephritis, PKD, BPH, urinary tract TB
• Miscellaneous: coagulopathy, sickle cell, IE, menstruation, rhabdomyolysis
Green • Methylene blue, triamterene, myoglobinuria when mild
• Severe haemoglobinuria
Black • Melanoma, ochronosis; porphyrins, alkaptonuria (red to black on standing)
• Drugs: Methyldopa, metronidazole, unipenem
White/milky • Chyluria (Pus, chyle (lymphatic fluid) or blood can cause a more turbid appearance)
• Phosphate or urate deposits can occur normally and produce white (phosphate) or pink (urate) cloudiness
Cloudiness
• Fainter cloudiness may be due to bacteria



Smell of urine Underlying cause
mild ammoniacal smell • normal
fishy smell • urinary tract infection (UTI)
Asparagus smell • antibiotics


Types Of Incontinence [cannot hold urine]

Stress incontinence Urge Incontinence Overflow incontinence INNERVATION TO URINATE
(outlet incompetence) (detrusor overactivity) • PSNS è ACh è detrusor relax [PROPULSION]
Inability of sphincters to hold Sudden contraction of detrusor muscle Underactive bladder • SNS è NA è sphincter contracts [STORAGE]
urine = Involuntary urine when bladder only partially filled ® causing urine to leak out • Somatic pudendal è external urethral sphincter
Issue leakage (esp. on ↑intra-abdo [large volume – sudden urge] (incomplete emptying) (voluntary control)
pressure = cough /sneeze / Ø Dry = reaches toilet in time [low volume]
exercise) Ø Wet = cannot make to toilet
1) Weak abdo muscles 1) UTI Ø MAIN = Chronic
(multipregnancy) 2) Overactive bladder syndrome urinary retention
2) +++ intra-abdo pressure > 3) Bladder Stone/clot/tumour (e.g. opioid usage)
closing pressure of 4) Neuro = T2DM, SCI – stroke, Ø Obstruction =
urethral sphincter = Alzheimer, PD, Urethral stricture,
RF obesity, heavy lifting, Stones, UTI
chronic cough Key notes: Ø Weak bladder
3) Sphincter tone failure = 5) Triggers = Advanced age, muscles = NMD,
childbirth trauma Smoking diabetic cystopathy
4) Loss of urethral support 6) URODYNAMIC studies needed
= post-meno E2 def.
Ø Prolapse Sx = fullness, dragging, back ache Basic Investigations
Ø Sexual Sx = dyspareunia Ø UA MSU + M/C/S
Ø Pelvic pain = bladder, pudendal neuralgia (worse on sitting) ® if Ø Pelvic USS (post and
relieved with pudendal block (= NANTES) pre-void residue)
Exam + Ix
Ø +ve Cough/stress test = stress leak Ø Uroflowmetry
Ø DRE = assess anal sphincter tone + rectocele Ø Intake-void diary (3-5
Ø Neuro exam (L1-S4) = perineum sensation + sacral reflex (anal days)
wink)
Ø Reduce BMI < 25 Ø ↓↓fluid intake (esp. ↓caffeine, Ø Timed voiding
o NEAT regime ↓EtOH, soda) (bladder retraining)
Ø PT = Kegel exercise (If no Ø Timed voiding (bladder
Conservative hip #) especially post- retraining)
pregnancy for prevention Ø Manage constipation IMPORTANT DIFFERENTIAL FOR “LEAKY URINE”
Ø Vaginal pessary (1st line for Ø UTI – “burning, stinging sensation + frequency”
prolapses) Ø PROLAPSE - fullness
Ø + metformin (if DM) Ø Oxybutynin (anti-chol -M3 to Ø Local E2 ® manage Ø HERNIA – reducible (DDx: incarcerated)
Ø Topical estrogen ↓ACh – ANTI-SLUDGE) post-meno atrophy Ø NEURO – MS, DM, Cauda Equina
Ø Mirabegron (B3 agonist – less *Flomax (tamsulosin) in Transient incontinence [DIAPPERS]
Medical
A/E) men for both urge and Ø Delirium,
Ø Duloxetine = SNRI ® ↑ contract overflow Ø infection,
internal urethral sphincter Ø atrophic urethritis,
Ø Mid-urethral sling - Ø Botulinum toxin ® blocks ACH Ø IDC (self- Ø pharm, psych,
tension free vaginal tape release ® injected directly into catheterise) Ø XS urine (caffeine, EtOH),
(TVT) bladder via cystoscopy (Pt must Ø Continuous bladder Ø restricted mobility,
Ø Colposuspensions self-catheterize as botox can lead drain
Ø stool incontinence
(laparscopically) to urinary retention)
Surgical Other types of incontinence)
*Rarely used = urethral injections Ø Neuromodulation ® posterior
(bulking agents e.g. silicon) Ø Mixed
tibial or sacral nerve ® inhibit
Ø True/continuous (? Fistula, ectopic ureter)
reflex contraction of bladder
Ø Nocturnal uresis
Ø Situations (coital/giggle)

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