An elderly patient is suffering from depression was given St. John's Wort.
Which of the following drugs if administered concomitantly will have a
clinically significant interaction?
A. Simvastatin
B. Salbutamol
C. Sertraline
D. Gliclazide
The high prevalence of osteoporosis in the elderly results which incidence in geriatric
population?
A. Hyperkalemia
B. Bone fractures
C. Urinary retention
D. Memory impairment
An elderly man presented to the Emergency Room with dizziness, altered
consciousness, respiratory depression and rhabdomyolysis. He was recently
prescribed a medication for inability to sleep.
Which is the most likely drug toxicity?
A. Benzodiazepines
B. Acetaminophen
C. Salicylate
D. Opioid
A man weighs 78 Kg is to be administered one gram vancomycin intravenously
every 12 hours for seven days. The half-life of vancomycin is approximately eight
hours and volume of distribution is approximately 1 L/ Kg. What is the expected
average steady state plasma concentration in mg/L of vancomycin?
A. 5
B. 7
C. 13
D. 19
𝐷𝑜𝑠𝑒 1000 𝑚𝑔
Ans: Cpss= = =12.3 ~13mg/L
𝑉𝑑.𝐾𝑒.𝑇 78𝑋0.0867𝑋12
An antibiotic has an elimination rate constant of 0.05 per hour and apparent
volume of distribution of 0.6 L/Kg. What will be the clearance value in a 75 Kg
adult?
A. 1 .75 L/hrs
B. 2.25 L/hrs
C. 3.55 L/hrs
D. 4.25 L/hrs
Ans: Cl =Vd.ke = (0.6 X 75) X 0.05 = 2.25 L/hrs
, A 45 year-old patient of rheumatoid arthritis has been prescribed naproxen 250 mg
enteric coated tablets twice daily. The elimination half-life of naproxen is 12 hours.
How much time it would take to reach the 95% of steady state plasma concentration?
A. 22.3 hrs
B. 38 .7 hrs
C. 51 .6 hrs
D. 66.5 hrs
Ans: Time to reach 95% steady state conc. require 4.3 half-lives (t1/2) 4.3 X 12 = 51.6 h
A 35 year-old individual is receiving 20 mg of propranolol hydrochloride four times
daily as a prophylaxis to migraine attacks. If the drug has only 25% bioavailability
due to extensive first pass effect. What amount of the drug reaches the systemic
circulation after each dosing?
A. 2.5 mg
B. 5.0 mg
C. 7.5 mg
D. 10 mg
𝑚𝑎𝑠𝑠 𝑜𝑓 𝑑𝑟𝑢𝑔 𝑑𝑒𝑙𝑖𝑣𝑒𝑟𝑒𝑑 𝑡𝑜 𝑝𝑙𝑎𝑠𝑚𝑎
Ans: F = = Mass = 25% X 20 mg = 5 mg
𝑡𝑜𝑡𝑎𝑙 𝑚𝑎𝑠𝑠 𝑜𝑓 𝑡ℎ𝑒 𝑑𝑟𝑢𝑔 𝑎𝑑𝑚𝑖𝑛𝑖𝑠𝑡𝑟𝑎𝑖𝑜𝑛
An NSAID has an oral dose of 200 mg, bioavailability of 80% and elimination half-
life of four hours. How much drug will be remaining in the body after 12 hours?
A. 20 mg
B. 40 mg
C. 60 mg
D. 80 mg
Ans: Mass = 200X80%=160mg
Total hrs. =12h
(After 4h will reach its half “80mg” after another 4 h “40 mg” after another 4h “20 mg”)
Which one of the medications can be dispensed without prescription?
A. Insulin vials
B. Metoprolol 50 mg tablet
C. Ibuprofen 400 mg tablet
D. Aripiprazole 10 mg tablet
What is the indication of pseudoephedrine?
A. Nasal congestion
B. Pyrexia
C. Allergy
D. Pain
, What is the appropriate recommendation for diclofenac oral tablet use?
A. With food or milk to decrease GI upset
B. Take with fatty meals to enhance absorption
C. Two hours after meals to avoid delay in absorption
D. Four hours before meals to prevent drug-food interaction
In which one of the following conditions estrogen containing contraceptive is contraindicated?
A. Depression
B. Uncomplicated diabetes
C. Controlled hypertension
D. 40 year-old women who smoke
A 31 year-old, three months pregnant woman, develops urinary tract infection. What is the
most appropriate antimicrobial therapy?
A. Tetracycline
B. Ciprofloxacin
C. Nitrofurantoin
D. Sulfamethoxazole and trimethoprim
A 38 year-old man with invasive aspergillosis is receiving voriconazole.
Which of the following disease states warrant dose adjustment?
A. Colon cancer
B. Renal failure
C. Hepatic cirrhosis
D. No dose adjustments is needed for voriconazole
Which of the following substances is classified as a weak electrolyte?
A. Urea
B. Dextrose
C. Creatinine
D. Calcium chloride
Calcium chloride is strong electrolyte, the other options are non-electrolytes. I think there’s something
wrong in the ques!
Which of the following bases can be used to prepare rectal suppositories?
A. Sucrose
B. Cocoa butter
C. Methylcellulose
D. Propylene glycol
, Which of the following replacement fluids is an isotonic solution?
A. 3% Saline
B. 5% dextrose
C. Ringers lactate
D. 1/2 strength normal saline
The pharmacy received a call from the Intensive Care Unit nurse who has a patient receiving an
intravenous solution containing amoxicillin. The doctor has now ordered morphine to be injected
into the Y site of the intravenous solution every 4 hours. The nurse wants to know if these drugs
will be compatible at the Y site. From which references the pharmacist should provide the
required information?
A. Red book
B. Merck manual
C. Review of natural products
D. Handbook on injectable drugs
Which of the following parenteral anticoagulants require routine
monitoring of coagulation lab parameters?
A. UFH intravenously
B. IJFH subcutaneously
C. Enoxaparin subcutaneously
D. Fondaparinux subcutaneously
What is the possible serious side effect that is common amongst all
anticoagulant agents?
A. Hypokalemia
B. Major Bleeding
C. Liver Dysfunction
D. Renal Dysfunction
Stroke or previous TIA is a contraindication to the use of which antiplatelet agent?
A. Aspirin
B. Prasugrel
C. Ticagrelor
D. Clopidogrel
Which of the following drugs if administered concomitantly will have a
clinically significant interaction?
A. Simvastatin
B. Salbutamol
C. Sertraline
D. Gliclazide
The high prevalence of osteoporosis in the elderly results which incidence in geriatric
population?
A. Hyperkalemia
B. Bone fractures
C. Urinary retention
D. Memory impairment
An elderly man presented to the Emergency Room with dizziness, altered
consciousness, respiratory depression and rhabdomyolysis. He was recently
prescribed a medication for inability to sleep.
Which is the most likely drug toxicity?
A. Benzodiazepines
B. Acetaminophen
C. Salicylate
D. Opioid
A man weighs 78 Kg is to be administered one gram vancomycin intravenously
every 12 hours for seven days. The half-life of vancomycin is approximately eight
hours and volume of distribution is approximately 1 L/ Kg. What is the expected
average steady state plasma concentration in mg/L of vancomycin?
A. 5
B. 7
C. 13
D. 19
𝐷𝑜𝑠𝑒 1000 𝑚𝑔
Ans: Cpss= = =12.3 ~13mg/L
𝑉𝑑.𝐾𝑒.𝑇 78𝑋0.0867𝑋12
An antibiotic has an elimination rate constant of 0.05 per hour and apparent
volume of distribution of 0.6 L/Kg. What will be the clearance value in a 75 Kg
adult?
A. 1 .75 L/hrs
B. 2.25 L/hrs
C. 3.55 L/hrs
D. 4.25 L/hrs
Ans: Cl =Vd.ke = (0.6 X 75) X 0.05 = 2.25 L/hrs
, A 45 year-old patient of rheumatoid arthritis has been prescribed naproxen 250 mg
enteric coated tablets twice daily. The elimination half-life of naproxen is 12 hours.
How much time it would take to reach the 95% of steady state plasma concentration?
A. 22.3 hrs
B. 38 .7 hrs
C. 51 .6 hrs
D. 66.5 hrs
Ans: Time to reach 95% steady state conc. require 4.3 half-lives (t1/2) 4.3 X 12 = 51.6 h
A 35 year-old individual is receiving 20 mg of propranolol hydrochloride four times
daily as a prophylaxis to migraine attacks. If the drug has only 25% bioavailability
due to extensive first pass effect. What amount of the drug reaches the systemic
circulation after each dosing?
A. 2.5 mg
B. 5.0 mg
C. 7.5 mg
D. 10 mg
𝑚𝑎𝑠𝑠 𝑜𝑓 𝑑𝑟𝑢𝑔 𝑑𝑒𝑙𝑖𝑣𝑒𝑟𝑒𝑑 𝑡𝑜 𝑝𝑙𝑎𝑠𝑚𝑎
Ans: F = = Mass = 25% X 20 mg = 5 mg
𝑡𝑜𝑡𝑎𝑙 𝑚𝑎𝑠𝑠 𝑜𝑓 𝑡ℎ𝑒 𝑑𝑟𝑢𝑔 𝑎𝑑𝑚𝑖𝑛𝑖𝑠𝑡𝑟𝑎𝑖𝑜𝑛
An NSAID has an oral dose of 200 mg, bioavailability of 80% and elimination half-
life of four hours. How much drug will be remaining in the body after 12 hours?
A. 20 mg
B. 40 mg
C. 60 mg
D. 80 mg
Ans: Mass = 200X80%=160mg
Total hrs. =12h
(After 4h will reach its half “80mg” after another 4 h “40 mg” after another 4h “20 mg”)
Which one of the medications can be dispensed without prescription?
A. Insulin vials
B. Metoprolol 50 mg tablet
C. Ibuprofen 400 mg tablet
D. Aripiprazole 10 mg tablet
What is the indication of pseudoephedrine?
A. Nasal congestion
B. Pyrexia
C. Allergy
D. Pain
, What is the appropriate recommendation for diclofenac oral tablet use?
A. With food or milk to decrease GI upset
B. Take with fatty meals to enhance absorption
C. Two hours after meals to avoid delay in absorption
D. Four hours before meals to prevent drug-food interaction
In which one of the following conditions estrogen containing contraceptive is contraindicated?
A. Depression
B. Uncomplicated diabetes
C. Controlled hypertension
D. 40 year-old women who smoke
A 31 year-old, three months pregnant woman, develops urinary tract infection. What is the
most appropriate antimicrobial therapy?
A. Tetracycline
B. Ciprofloxacin
C. Nitrofurantoin
D. Sulfamethoxazole and trimethoprim
A 38 year-old man with invasive aspergillosis is receiving voriconazole.
Which of the following disease states warrant dose adjustment?
A. Colon cancer
B. Renal failure
C. Hepatic cirrhosis
D. No dose adjustments is needed for voriconazole
Which of the following substances is classified as a weak electrolyte?
A. Urea
B. Dextrose
C. Creatinine
D. Calcium chloride
Calcium chloride is strong electrolyte, the other options are non-electrolytes. I think there’s something
wrong in the ques!
Which of the following bases can be used to prepare rectal suppositories?
A. Sucrose
B. Cocoa butter
C. Methylcellulose
D. Propylene glycol
, Which of the following replacement fluids is an isotonic solution?
A. 3% Saline
B. 5% dextrose
C. Ringers lactate
D. 1/2 strength normal saline
The pharmacy received a call from the Intensive Care Unit nurse who has a patient receiving an
intravenous solution containing amoxicillin. The doctor has now ordered morphine to be injected
into the Y site of the intravenous solution every 4 hours. The nurse wants to know if these drugs
will be compatible at the Y site. From which references the pharmacist should provide the
required information?
A. Red book
B. Merck manual
C. Review of natural products
D. Handbook on injectable drugs
Which of the following parenteral anticoagulants require routine
monitoring of coagulation lab parameters?
A. UFH intravenously
B. IJFH subcutaneously
C. Enoxaparin subcutaneously
D. Fondaparinux subcutaneously
What is the possible serious side effect that is common amongst all
anticoagulant agents?
A. Hypokalemia
B. Major Bleeding
C. Liver Dysfunction
D. Renal Dysfunction
Stroke or previous TIA is a contraindication to the use of which antiplatelet agent?
A. Aspirin
B. Prasugrel
C. Ticagrelor
D. Clopidogrel
