LE2 College aantekeningen Kidney Physiology (NWI-BM079) - Tubule: The Nephron

LE 2 – Tubule
November 8th, 2023

Plasma Osmolality & Volume
 Control of body fluid volume (i.e., renin-angiotensin-aldosterone system to control NaCl
excretion).
 Control of body fluid osmolality (i.e., vasopressin secretion to control water excretion).
 Osmolarity = amounts of molecules in a volume.
 Osmolality = molecules that contribute to balance.

Segmental Ion Transmission along the Nephron




PCT Proximal Convoluted Tubule  bulk transport, reabsorption of sodium, potassium, calcium
(paracellular transport).
TAL Thick Ascending Limb  paracellular transport
DCT Distal Convoluted Tubule  transcellular transport
CD Collecting Duct  transcellular transport

Negative K = secretion instead of uptake. Calcium phosphate will result in kidney stones.

, Tubular Transport Disorders




Paracellular and Transcellular Transport