Farrier
Kern
Hematological disorder characterized by Panctopenia with criteria
megaloblastichyperplasia of BM Macrocytes evidence
Good response to B12 8 folic acit GIT 8 Neuro manifestations
B12 deficiency 1intake A intrinsicfactor Perniciousanemia or
chronic liverdisease Bodystoressufficientfor 3Yrs
folicaciddeficiency intake Absorption Drugs ex methotrexate
Requirements
NB isolatedfolic acid def donot cause neuro manifestations
111Pernicious Anemia intrinsic factor Autoimmuneex parietalcells Antibodies
vacate
1 Neuro manifestations 3P As B12 is important in formation ofmyelinsheath
peripheral neuropathy pyramidal tract lesion
Posterior column loss of deepsensations
I GET manifestations 3Atrophy atrophicglossitis atrophicgastritis
I spleenomegally Atrophy in intestine
I n
I CBC Pandytopenia MCV MCH MCHCN 111B12 2100 1 200
AnisoOltosis differentRBCs sizes folic 24 N 6 20
Poikilocytosis differentRBCsshapes Iv schilling test
BM megaloblasticmperplasia
Therapeutic test Good response to B12 or folic acid Reticulocytosis
serological test Anti Parietal AB Anti intrinsic factor AB
VII FIGLU es the in folic acid deficiency Give oral histidine
Emas
life long treatment 12H
1st week weekly1stmont
Vit B12def I m injection ooo mg monthly for life
folicacidset 5mg day oral B12 C
qq.gg Tgkiacigqetth
Arrest of division due to eficiencyessential forDNAsynthes
i ineffective erythropoiesis
macrocytes evidence
Rapid hemolysis BY spleen lead to splenomegaly
Kern
Hematological disorder characterized by Panctopenia with criteria
megaloblastichyperplasia of BM Macrocytes evidence
Good response to B12 8 folic acit GIT 8 Neuro manifestations
B12 deficiency 1intake A intrinsicfactor Perniciousanemia or
chronic liverdisease Bodystoressufficientfor 3Yrs
folicaciddeficiency intake Absorption Drugs ex methotrexate
Requirements
NB isolatedfolic acid def donot cause neuro manifestations
111Pernicious Anemia intrinsic factor Autoimmuneex parietalcells Antibodies
vacate
1 Neuro manifestations 3P As B12 is important in formation ofmyelinsheath
peripheral neuropathy pyramidal tract lesion
Posterior column loss of deepsensations
I GET manifestations 3Atrophy atrophicglossitis atrophicgastritis
I spleenomegally Atrophy in intestine
I n
I CBC Pandytopenia MCV MCH MCHCN 111B12 2100 1 200
AnisoOltosis differentRBCs sizes folic 24 N 6 20
Poikilocytosis differentRBCsshapes Iv schilling test
BM megaloblasticmperplasia
Therapeutic test Good response to B12 or folic acid Reticulocytosis
serological test Anti Parietal AB Anti intrinsic factor AB
VII FIGLU es the in folic acid deficiency Give oral histidine
Emas
life long treatment 12H
1st week weekly1stmont
Vit B12def I m injection ooo mg monthly for life
folicacidset 5mg day oral B12 C
qq.gg Tgkiacigqetth
Arrest of division due to eficiencyessential forDNAsynthes
i ineffective erythropoiesis
macrocytes evidence
Rapid hemolysis BY spleen lead to splenomegaly
