Chapter 10 B-Cell Development Updated Version.

Chapter 10 B-Cell Development Updated Version.1. B lymphocytes are made in the: A. blood stream. B. bone marrow. C. liver. D. thymus. E. totipotent cell. - answerAnswer: B Section: Introduction Difficulty: 1 Hint: Location of B cell production from a HSC. 2. How long does B cell maturation from an HSC to a mature B cell take? A. 1 to 2 hours B. 1 to 2 days C. 1 to 2 weeks D. 1 to 2 months E. 1 to 2 years - answerAnswer: C Section: Introduction Difficulty: 1 Hint: B cell will begin to secrete antibodies within a few days of infection. 3. Which cell type is found in both B- and T-cell lineages? A. Common lymphoid progenitors B. Common pro-B-T cells C. Immature B cell D. Naïve lymphoid progenitor E. Pro-B-T cell - answerAnswer: A Section: Introduction Difficulty: 1 Hint: B cells belong to the lymphoid lineage. 4. This type of cell will leave the bone marrow and complete maturation in the spleen. A. Common lymphoid progenitor cell B. hematopoietic stem cell C. immature B cell D. pro-B cell E. pro-T cell - answerAnswer: C Section: Introduction Difficulty: 1 Hint: B cells will see potential antigens in the germinal centers of secondary lymphoid organs such as the spleen. 5. All of the following are true regarding B-cell development EXCEPT: A. B cells complete maturation in the spleen. B. B cells are mostly developed when they leave the bone marrow. C. B cells, like T cells, are MHC class restricted. D. Self-reactive B cells may be eliminated though apoptosis. E. Self- reactive B cells may be rendered unreactive (anergic). - answerAnswer: C Section: Introduction Difficulty: 2 Hint: B cells display IgD as their BCR. 6. Hematopoiesis produces: A. B cells only. B. Red blood cells only. C. myeloid lineage cells only. D. lymphoid and myeloid lineage cells. E. erythorid, lymphoid, and myeloid lineage cells. - answerAnswer: E Section: The Site of Hematopoiesis Difficulty: 2 Hint: Hematopoietic stem cells produce all blood cells.