Chapter 49: Immune Blockers Introductory Clinical Pharmacology 12th Edition by Susan M Ford

Introductory Clinical Pharmacology 12th Edition by Susan M Ford 1. The nurse works with a number of clients who require immunosuppressive treatment of autoimmune diseases. What classes of drugs would the nurse expect health care providers to order? Select all that apply. a. Corticosteroids b. Calcineurin inhibitors c. Sodium channel antagonists d. Biologics e. Antibiotics f. Diuretics Answer: A, B, D Rationale: Drugs used to suppress immunity include corticosteroids, calcineurin inhibitors, mTOR inhibitors, IMDH inhibitors, biologics, and monoclonal antibodies. Sodium channel antagonists are used to treat chronic angina. Antibiotics are used to treat bacterial infections. Diuretics are medications designed to increase the amount of water and salt expelled from the body as urine and lower blood pressure. Question format: Multiple Choice Chapter: 49 Learning Objective: 1 Cognitive Level: Remember Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Clinical Problem-solving Process (Nursing Process) Reference: p. 666, Immunosuppressant Drugs 2. A nurse is teaching a client about immunosuppressive medication. Which client statement validates that the teaching was successful? a. “They are drugs that increase the production of T lymphocytes.” b. “They decrease the strength of the body’s immune response.” c. “They reduce organ rejection in transplant clients.” d. “These drugs attack the body’s own tissue as if it were foreign.” Answer: B Rationale: Immunosuppressive drugs are agents that reduce the strength of the body’s own immune system. These medications also inhibit the inflammatory response, inhibit the action of T cells, and reduce antibody formation. These medications are used to treat autoimmune disease and reduce organ rejections in transplant clients. Autoimmune diseases usually attack the body’s own tissues as foreign, resulting in the development of the disease. Question format: Multiple Choice Chapter: 49 Learning Objective: 2 Cognitive Level: Apply Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Teaching/Learning Reference: p. 666, Immunosuppressant Drugs 3. A nurse is reviewing the electronic health record of a client who has been prescribed monoclonal antibody. The nurse would contact the prescriber if a history of which disease is documented? a. Ulcerative colitis b. Multiple sclerosis c. Rheumatoid arthritis d. Hepatitis B Answer: D Rationale: Monoclonal antibodies are used in the treatment of a variety of diseases, including multiple sclerosis, ulcerative colitis, and rheumatoid arthritis. Viral infections, such as hepatitis B, can be reactivated during therapy, so the nurse should contact the prescriber if this disease is documented in the history. Question format: Multiple Choice Chapter: 49 Learning Objective: 2 Cognitive Level: Apply Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Clinical Problem-solving Process (Nursing Process) Reference: p. 667, Monoclonal Antibodies 4. A nurse is providing teaching to a client who will undergo kidney transplantation. Which statement will the nurse include in the teaching regarding medications taken following the procedure? A. “Antirejection drugs are taken to prevent the body from rejecting the new kidney.” B. “You will take the drugs if you experience complications from the procedure.” C. “Immunotherapy medications will suppress the immune response of the new kidney.” D. “You’ll have to take the medications if the match with the donor kidney is not exact.” Answer: A Rationale: The new organ is as much of a threat to the body as foreign microorganisms, and as a result, the immune system recognizes the foreign cell and attacks it. Immunotherapy medications or antirejection drugs are used to suppress the production and activity of the body’s own immune cells. Immunotherapy is used as a long-term treatment to protect the new organ. They are not taken only in the presence of complications, and they are used even if the there is a match between the two individuals. Question format: Multiple Choice Chapter: 49 Learning Objective: 2 Cognitive Level: Apply Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Teaching/Learning Reference: p. 666, Organ Transplant 5. A client with a kidney transplant taking cyclosporine has a laboratory requisition. Which laboratory tests would the nurse expect on the requisition? Select all that apply