NUR 601 Pharm exam 2 question well done2023/2024.

Prochlorperazine Promethazine Droperidol - answersantipsychotic/antiemetic-- blocks dopamine receptors in brain (adverse: anticholineric, OTH, increased HR, extrapyramidal) Bonjesta & Diclegis - answersSerotonin Receptor Antagonist: 1st line morning sickness (doxclilamine + B6) Aprepitant (Emend) - answershighly selective oral P Neurokinin1 (NKI) receptor antagonist. Prevention of CINV in combo with standard antiemetic regimens Fosaprepitant - answersIV drug converted to Aprepitant in 30 min Amiodarone & Fluoroquinolones (prolong QT) - answersavoid these drugs with serotonin receptor antagonist antiemetics Decadron - answersenhance the efficacy of 5-HT3 (serotonin) receptor antagonists for CINV (short term use) 5HT3 antagonist, decadron, & NKI antagonist - answerstriple therapy antiemetics PPI BID, Clarithromycin, Amoxicillin or Metronidazole - answers1st line therapy for H. Pylori Calcium carbonate (TUMS) - answersantacids that can cause kidney stones & constipation magnesium hydroxide & H2 antagonists - answersAssess for renal insufficiency with these antacids Cimetidine (Tagamet) - answersH2 antagonist with CYP interactions PPI's - answersirreversibly binds to enzyme H, K-ATPase to inhibit the proton pump Clopidogrel (Plavix) - answersOmeprazole inhibits CYP 2C19 which my inhibit metabolism of -- Misoprostol (Cytotec) - answersAVOID this if pregnant! inhibits gastric production & stimulates production of mucous -psyllium -methycellulose - answersBulk laxatives: MUST take with water -promotes peristalsis Mg Hydroxide or Mg Citrate - answersosmotic laxative: avoid in renal patients Torsades de pointe - answersMajor risk with Loperamide (Imodium) -Linaclotide (Linzess) -Lubiprostone (Amitiza)- women only -PEG laxatives - answersDrugs used if IBS with constipation Linaclotide (Linzess) - answersDrug used of IBS with constipation that increases intestinal fluid so stool softens -Mesalamine PR -Hydrocortisone PR - answersTreatment of mild/moderate U.C. Zetia - answerscholesterol absorption inhibitor, acts as brush boarder for small intestine -pancreatitis -fasting triglycerides 300 - answerscontraindications for bile acid resins (Questran) warfarin - answersFibric Acid Derivative (Gemfibrozil) can increase PCSK9 inhibitors (Praluent & Repatha) - answersmonoclonal antibodies used in patients on high intensity statin Antithrombin 3 - answersHeparin binds reversibly to -- -Dabigatran -Rivaroxaban -Apixaban -Edoxaban - answerspreferred oral anticoag meds for a. fib LMWH - answerstype of heparin you cannot use in renal patients Unfractionated Heparin - answerstype of heparin you CAN use in renal patients Rivaroxaban (Xarelto) -Apixaban (Eliquis) - answersFactor Xa inhibitor, given as fixed dose, no monitoring. More rapid onset & shorter half life than warfarin. PCC (Kcentra) (if not available use plasma) - answerswarfarin antidote Idarucizumab - answersDabigatran antidote