NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGY
FACULTY OF MEDICINE
DIVISION OF BASIC MEDICAL SCIENCES
BACHELOR OF MEDICINE AND BACHELOR OF SURGERY DEGREE
PART I FINAL EXAMINATIONS
MBM 1202 : BIOCHEMISTRY PAPER II
DATE : JUNE 2013
TIME : 3 HOURS
Instructions to Candidates
Answer all questions
1. What are the causes of phenylketonuria and how is it managed? (7)
2. Acetyl CoA can be described as a “cross-road” molecule. Sketch its metabolic
sources and its utilization. (4)
3. Map the distribution of amino acids in the well-fed state. (5)
4. Briefly, explain the biochemical bases of neonatal jaundice. (5)
5. Differentiate between the terms “metabolomics” and “metabonomics”. (4)
6. Differentiate between glucogenic and ketogenic amino acids. Are these
interconvertible? (6)
7. Explain the strategies used to regulate the synthesis of the non-essential amino
acids that are derived from glutamate. (5)
8. What is the biochemical basis of maple syrup urine disease and its sequelae? (5)
9. Write short notes explaining the roles of prostaglandin H2 synthase in local
hormone synthesis. (5)
Page 1 of 3
FACULTY OF MEDICINE
DIVISION OF BASIC MEDICAL SCIENCES
BACHELOR OF MEDICINE AND BACHELOR OF SURGERY DEGREE
PART I FINAL EXAMINATIONS
MBM 1202 : BIOCHEMISTRY PAPER II
DATE : JUNE 2013
TIME : 3 HOURS
Instructions to Candidates
Answer all questions
1. What are the causes of phenylketonuria and how is it managed? (7)
2. Acetyl CoA can be described as a “cross-road” molecule. Sketch its metabolic
sources and its utilization. (4)
3. Map the distribution of amino acids in the well-fed state. (5)
4. Briefly, explain the biochemical bases of neonatal jaundice. (5)
5. Differentiate between the terms “metabolomics” and “metabonomics”. (4)
6. Differentiate between glucogenic and ketogenic amino acids. Are these
interconvertible? (6)
7. Explain the strategies used to regulate the synthesis of the non-essential amino
acids that are derived from glutamate. (5)
8. What is the biochemical basis of maple syrup urine disease and its sequelae? (5)
9. Write short notes explaining the roles of prostaglandin H2 synthase in local
hormone synthesis. (5)
Page 1 of 3
