NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGY
FACULTY OF MEDICINE
DIVISION OF BASIC MEDICAL SCIENCES
BACHELOR OF MEDICINE AND BACHELOR OF SURGERY DEGREE
PART I FINAL EXAMINATIONS
MBM 1202 : BIOCHEMISTRY PAPER 1
DATE : JUNE 2013
TIME : 3 HOURS
Instructions to Candidates
Answer all questions in the answer booklet provided
1. Compare and contrast the metabolic shifts that characterise the overnight fast
and the adapted starved state. (20)
2. Outline haem biosynthesis and describe the regulation of this pathway. Elucidate
the metabolic derangements that characterise congenital erythropoietic porphyria
(CEP). (20)
3. Different cells can respond differently to the same extracellular signal molecule.
Using a particular hormone or hormones as examples, discuss the validity of this
statement. (20)
4. Giving examples of the hormones that utilize each type of receptor, discuss how
the major types of hormonal receptors function in signal transduction.
Use diagrams to illustrate your answer. (20)
5. Describe the pentose phosphate pathway, highlighting the tissue and cellular
distribution of the enzymes of the pathway, reaction sequence and its biological
significance. (20)
END OF EXAMINATION
Page 1 of 1
FACULTY OF MEDICINE
DIVISION OF BASIC MEDICAL SCIENCES
BACHELOR OF MEDICINE AND BACHELOR OF SURGERY DEGREE
PART I FINAL EXAMINATIONS
MBM 1202 : BIOCHEMISTRY PAPER 1
DATE : JUNE 2013
TIME : 3 HOURS
Instructions to Candidates
Answer all questions in the answer booklet provided
1. Compare and contrast the metabolic shifts that characterise the overnight fast
and the adapted starved state. (20)
2. Outline haem biosynthesis and describe the regulation of this pathway. Elucidate
the metabolic derangements that characterise congenital erythropoietic porphyria
(CEP). (20)
3. Different cells can respond differently to the same extracellular signal molecule.
Using a particular hormone or hormones as examples, discuss the validity of this
statement. (20)
4. Giving examples of the hormones that utilize each type of receptor, discuss how
the major types of hormonal receptors function in signal transduction.
Use diagrams to illustrate your answer. (20)
5. Describe the pentose phosphate pathway, highlighting the tissue and cellular
distribution of the enzymes of the pathway, reaction sequence and its biological
significance. (20)
END OF EXAMINATION
Page 1 of 1
