Biochemistry II: Exam 2 Questions And Answers

With regards to fatty acid synthesis, what is not inhibited by glucose 6 phosphate and what is inhibited by it? - Correct Answer 1. Not - Liver 2. Is - muscle What are the primary tissues for fatty acid synthesis? - Correct Answer 1. Liver 2. Lesser extent adipose tissue, & kidney 3. Mammary glands during lactation Where does fatty acid synthesis occur? - Correct Answer 1. In the cytosol What is the general mechanism of fatty acid synthesis? - Correct Answer 1. Incorporation of 2 carbon molecules (acetyl) 2. NADPH provides reducing power 3. ATP is consumed What 2 molecules are needed to start the process od fatty acid synthesis? - Correct Answer 1. Acetyl CoA (2 carbons) 2. Malonyl CoA (3 carbons) What is malonyl made from? - Correct Answer 1. Acetyl What is the mechanism of synthesis for fatty acids? - Correct Answer 1. Get acetyl to the cytosol 2. Make Malonyl CoA 3. Multienzyme complex Oxidation of _________ makes acetyl CoA and occurs where? - Correct Answer 1. Pyruvate 2. In the mitochondria With regards to getting acetyl to the cytosol, the _____ portion cannot cross to the cytosol, so translocation occurs via ________. - Correct Answer 1. CoA 2. Citrate With regards to getting acetyl to the cytosol, citrate levels elevate when _____ _________ is inhibited. - Correct Answer 1. Isocitrate Dehydrogenase High levels of _____ inhibit Isocitrate Dehydrogenase. - Correct Answer 1. ATP Acetyl CoA requires what 4 things in order to become Malonyl CoA? - Correct Answer 1. Acetyl CoA Carboxylase 2. CO2