UNE medical biochemistry Unit 1 Test Questions With
Complete Solutions.
Changes in the physiological variables listed below can alter the affinity of
hemoglobin for oxygen. Which of the following will lower the affinity of
hemoglobin for oxygen?
a) decrease in protons
b) increase in 2,3 bisphosphoglycerate (BPG)
c) increase in pH
d) decrease in CO2
Increase in 2,3 bisphosphoglycerate (BPG)
Domains are common structural elements that retain a particular function within
the protein. Which of the following is an example of a protein domain?
a) a prosthetic group such as heme
b) irregular coils and loops
c) an arrangement of β-strands connected by α- helixes
d) a single α- helix
An arrangement of β-strands connected by α-helixes
A 22-year-old female is diagnosed with acute pancreatitis. Elevation of which of
the following serum enzymes would be consistent with this diagnosis?
a) lactate dehydrogenase
b) amylase
c) troponin
d) creatine kinase
amylase
Movement of ammonia from an amino acid to an alpha-keto acid involves a family
of enzymes best categorized as:
a) transferases
b) ligases
c) lyases
d) isomerases
transferases
Which of the following proteins is likely to have quaternary structure?
a) a protein that contains both α-helix and β-sheet secondary structures
b) a multimeric protein that contains multiple peptide chains
c) a small protein consisting of a single amino acid chain
d) a large transmemberane protein with seven alpha helical domains
a multimeric protein that contains multiple peptide chains
Cleavage of fructose 1, 6 bisphosphate to dihydroxyacetone and glyceraldehyde
3-phosphate is achieved by what class of enzymes?
, a) ligase
b) lyase
c) transferase
d) hydrolase
Lyase
Which of the following best describes the structure of heme?
a) a planar porphyrin ring that binds iron
b) a nicotinamide structure that is readily oxidized
c) an n-linked glycosylation
d) a negatively charged phosphate group
a planar porphyrin ring that binds iron
Prosthetic groups are complex nonprotein molecules that participate in catalysis
by providing functional groups that form a covalent intermediate between the
enzyme and the substrate. Which of the following is an example of a coenzyme or
cofactor that participates in a covalent catalysis reaction?
a) ATP
b) OH-
c) NADH
d) pyridoxal phosphate
pyridoxal phsophate
Which of the following best describes tertiary structure?
a) interactions between differing subunits of a protein
b) interactions between α-helixes and β-pleated sheets to form a domain
c) interactions between amino acids 4 residues away from each other
d) interactions between single amino acids adjacent to one another
interactions between α-helixes and β-pleated sheets to form a domain
Hemoglobin bound to heme is termed a holoprotein. The heme is required for
oxygen binding and is defined as which of the following?
a) apoprotein
b) holoprotein
c) heteroprotein
d) prosthetic group
prosthetic group
Children with cystinosis have growth delay and renal issues to to accumulation
of cysteine in cellular lysosomes. The defect involves a specific lysosomal
membrane receptor that facilitates cysteine removal from the cell. An effective
therapy involves administration of a drug with a similar structure to cysteine. This
therapy reflects the general principle that competitive inhibitors typically
resemble the structure of which of the following?
a) substrates or ligands that bind the active site
Complete Solutions.
Changes in the physiological variables listed below can alter the affinity of
hemoglobin for oxygen. Which of the following will lower the affinity of
hemoglobin for oxygen?
a) decrease in protons
b) increase in 2,3 bisphosphoglycerate (BPG)
c) increase in pH
d) decrease in CO2
Increase in 2,3 bisphosphoglycerate (BPG)
Domains are common structural elements that retain a particular function within
the protein. Which of the following is an example of a protein domain?
a) a prosthetic group such as heme
b) irregular coils and loops
c) an arrangement of β-strands connected by α- helixes
d) a single α- helix
An arrangement of β-strands connected by α-helixes
A 22-year-old female is diagnosed with acute pancreatitis. Elevation of which of
the following serum enzymes would be consistent with this diagnosis?
a) lactate dehydrogenase
b) amylase
c) troponin
d) creatine kinase
amylase
Movement of ammonia from an amino acid to an alpha-keto acid involves a family
of enzymes best categorized as:
a) transferases
b) ligases
c) lyases
d) isomerases
transferases
Which of the following proteins is likely to have quaternary structure?
a) a protein that contains both α-helix and β-sheet secondary structures
b) a multimeric protein that contains multiple peptide chains
c) a small protein consisting of a single amino acid chain
d) a large transmemberane protein with seven alpha helical domains
a multimeric protein that contains multiple peptide chains
Cleavage of fructose 1, 6 bisphosphate to dihydroxyacetone and glyceraldehyde
3-phosphate is achieved by what class of enzymes?
, a) ligase
b) lyase
c) transferase
d) hydrolase
Lyase
Which of the following best describes the structure of heme?
a) a planar porphyrin ring that binds iron
b) a nicotinamide structure that is readily oxidized
c) an n-linked glycosylation
d) a negatively charged phosphate group
a planar porphyrin ring that binds iron
Prosthetic groups are complex nonprotein molecules that participate in catalysis
by providing functional groups that form a covalent intermediate between the
enzyme and the substrate. Which of the following is an example of a coenzyme or
cofactor that participates in a covalent catalysis reaction?
a) ATP
b) OH-
c) NADH
d) pyridoxal phosphate
pyridoxal phsophate
Which of the following best describes tertiary structure?
a) interactions between differing subunits of a protein
b) interactions between α-helixes and β-pleated sheets to form a domain
c) interactions between amino acids 4 residues away from each other
d) interactions between single amino acids adjacent to one another
interactions between α-helixes and β-pleated sheets to form a domain
Hemoglobin bound to heme is termed a holoprotein. The heme is required for
oxygen binding and is defined as which of the following?
a) apoprotein
b) holoprotein
c) heteroprotein
d) prosthetic group
prosthetic group
Children with cystinosis have growth delay and renal issues to to accumulation
of cysteine in cellular lysosomes. The defect involves a specific lysosomal
membrane receptor that facilitates cysteine removal from the cell. An effective
therapy involves administration of a drug with a similar structure to cysteine. This
therapy reflects the general principle that competitive inhibitors typically
resemble the structure of which of the following?
a) substrates or ligands that bind the active site
