MLS CSMLS Exam Question Bank 2023| Over
700 Questions And Correct Answers, Verified
Solution
Which bleeding disorder is an inherited lack of fibrinogen, often diagnosed by
umbilical bleeding? (TT, PT, and APTT all increased)
Afibrinogenemia
What is the factor name of HMWK?
Fitzgerald factor
What is the factor name of prekallikrein?
Fletcher factor
What is the name of factor XIII?
Fibrin stabilizing factor
What is the name of factor XII?
Hageman factor
What is the name of factor XI?
Plasma thromboplastin antecedent
What is the name of factor X?
Stuart-Prower factor
What is the name of factor IX?
Christmas factor
What is the name of factor VIII?
Anti-hemophilic factor
What is the name of factor VII?
Stable factor
Which factor deteriorates at RT?
Factor V
What is the name of factor V?
Labile factor
What is the name of factor IV?
Ca2+
What is the name of factor III?
Tissue thromboplastin
What is the name of factor II?
Prothrombin
What is the name of factor I?
Fibrinogen
Which factors are consumed during clotting?
I, V, VIII, XIII
What are acquired pathologic plasma proteins - usually IgG Abs against factors -
that inhibit coagulation?
Circulating anticoagulants
,A test in which abnormal patient plasma is mixed 1:1 with normal control plasma
and the mixture is used for PT/APTT tests. If the abnormal result is not corrected,
a circulating anticoagulant is detected.
1:1 mix test
What is the critical value for INR?
>5.0
When should a patient have an APTT result that is 1.5-2x the normal value?
Heparin therapy
Which coagulation test measures the factors of the intrinsic and common
pathways and is used to monitor patients on heparin therapy?
APTT
When should a patient have a PT result that is 1.5-2x the normal value?
Coudamin (warfarin) therapy
Which coagulation test detects deficiencies in the extrinsic and common pathway
factors and is used to calculate INR to monitor patients on warfarin therapy?
PT
Which coagulation test measures the time required for thrombin to convert
fibrinogen to fibrin?
TT
Which coagulation test measures platelet number and function?
Bleeding time
What is caused by arterial thrombosis in the brain?
Stroke
What is caused by arterial thrombosis in the heart?
AMI
What is caused by arterial thrombosis in the limb?
Gangrene
How does plasmin activate complement?
Cleaves C3 into C3a and C3b
What is the name of C3a?
Anaphylatoxin
What is the name of C3b?
Opsonin
What does warfarin inhibit?
Vitamin K
What is a vitamin K dependent protease inhibitor that acts as a co-factor for
Protein C?
Protein S
What is a vitamin K dependent protease inhibitor that is activated by thrombin
and degrades factors V and VIII:C?
Protein C
Which protease inhibitor is the major natural inhibitor, also called heparin co-
factor because it is greatly accelerated by heparin, and is the major inactivator of
thrombin and Xa?
Antithrombin III (ATIII)
What is the main inhibitor of plasmin and inhibits rapidly?
,Alpha 2 antiplasmin
What is a plasmin inhibitor that inhibits slowly?
Alpha 2 macroglobulin
What enzyme is responsible for hydrolyzing fibrin, fibrinogen and other
coagulation proteins?
Plasmin
What system is activated when plasminogen that is bound to fibrin is converted
to plasmin by TPA?
Fibrinolytic system
What system results in enzymatic cleavage of the fibrin clot to soluble fragments
to re-establish blood flow?
Fibrinolytic system
What factors are involved in the common pathway?
I, II, V, X
Which coagulation tests can monitor the common pathway?
PT and APTT
Which pathway begins with the activation of factor X by the intrinsic and/or
extrinsic pathway?
Common
Which portion of factor VIII is the smallest portion, called the procoagulant
protein or anti-hemophilic portion, and acts as a co-factor for factor IXa to
activate factor X in the intrinsic pathway?
VIII:C
Which portion of factor VIII is the larger portion, called the carrier portion, and is
necessary for platelet adhesion to tissue?
VWF
Activation of which factor activates the intrinsic pathway, inflammation
(prekallikrein), fibrinolysis, and complement?
XII
Which factors are needed to amplify the contact factors to speed up the intrinsic
pathway?
Fletcher and Fitzgerald
Which factors are involved in the intrinsic pathway?
XII, XI, IX, VIII, Fletcher, Fitzgerald
Which factors are involved in the extrinsic pathway?
III, VII
High molecular weight proteins that are consumed during clotting and are acted
on by thrombin to convert fibrinogen to fibrin, includes factors I, V, VIII, and XIII
Fibrinogen proteins
Low molecular weight, vitamin K dependent proteins that contain the amino acids
necessary for Ca2+ binding, includes factors II, VII, IX, and X
Prothrombin proteins
Factors that in vitamin K deficiency will lack specific binding receptors for Ca2+
and therefore do not function normally, includes factors II, VII, IX, and X
PIVKAs (proteins induced by vitamin K absence)
, Proteins that are involved in the initial phase of intrinsic system activation,
includes factors XI, XII, Fletcher, and Fitzgerald?
Contact proteins
Which coagulation factors act as enzymes?
II, VII, IX, X, XI, XII, XIII
Which factors are proteases that cleave peptide bonds when activated?
II, VII, IX, X, XI, XII
Which factor is a transaminase that cross links fibrin monomers to give a stable
fibrin clot?
XIII
Which coagulation factors act as co-factors?
III, V, VIII:C, Fitzgerald
Factors that accelerate the reactions of enzyme coagulation factors
Co-factors
What coagulation factors act as substrates?
I
The type of factor that the enzymes act on
Substrate
Where is VWF produced?
Endothelial cells and megakaryocytes
Where are most of the coagulation factors produced?
Liver
A disorder of platelet secretion of ADP due to decreased stores of ADP/ATP in
dense granules, causing decreased aggregation
Storage pool deficiency
Which coagulation disorder is caused by decreased factor IX, has a normal PT,
bleeding time, and platelet count, but a prolonged APTT?
Hemophilia B
What is another name for Hemophilia B?
Christmas disease
Which coagulation disorder is caused by decreased factor VIII, has a normal PT,
bleeding time, and platelet count, but a prolonged APTT?
Hemophilia A
Which congenital platelet disorder is a disorder of platelet aggregation caused by
absence or deficiency of platelet receptors GIIb and GIIIa, therefore platelets
cannot bind fibrinogen, VWF, or fibronectin - bleeding time is increased, clot
retraction is absent, platelet morphology and function is normal?
Glanzmann's thrombasthenia
Which congenital platelet disorder is a rare disorder of adhesion caused by a
defect or lack of platelet receptor G1b, therefore platelets cannot bind to VWF on
endothelial cells - platelets are giant and poorly functioning, bleeding time is
increased, platelet count is decreased, clot retraction is normal?
Bernard Soulier
What is a treatment for VWD and sometimes Hemophilia A that induces release of
VWF from endothelial tissue?
DDVAP
700 Questions And Correct Answers, Verified
Solution
Which bleeding disorder is an inherited lack of fibrinogen, often diagnosed by
umbilical bleeding? (TT, PT, and APTT all increased)
Afibrinogenemia
What is the factor name of HMWK?
Fitzgerald factor
What is the factor name of prekallikrein?
Fletcher factor
What is the name of factor XIII?
Fibrin stabilizing factor
What is the name of factor XII?
Hageman factor
What is the name of factor XI?
Plasma thromboplastin antecedent
What is the name of factor X?
Stuart-Prower factor
What is the name of factor IX?
Christmas factor
What is the name of factor VIII?
Anti-hemophilic factor
What is the name of factor VII?
Stable factor
Which factor deteriorates at RT?
Factor V
What is the name of factor V?
Labile factor
What is the name of factor IV?
Ca2+
What is the name of factor III?
Tissue thromboplastin
What is the name of factor II?
Prothrombin
What is the name of factor I?
Fibrinogen
Which factors are consumed during clotting?
I, V, VIII, XIII
What are acquired pathologic plasma proteins - usually IgG Abs against factors -
that inhibit coagulation?
Circulating anticoagulants
,A test in which abnormal patient plasma is mixed 1:1 with normal control plasma
and the mixture is used for PT/APTT tests. If the abnormal result is not corrected,
a circulating anticoagulant is detected.
1:1 mix test
What is the critical value for INR?
>5.0
When should a patient have an APTT result that is 1.5-2x the normal value?
Heparin therapy
Which coagulation test measures the factors of the intrinsic and common
pathways and is used to monitor patients on heparin therapy?
APTT
When should a patient have a PT result that is 1.5-2x the normal value?
Coudamin (warfarin) therapy
Which coagulation test detects deficiencies in the extrinsic and common pathway
factors and is used to calculate INR to monitor patients on warfarin therapy?
PT
Which coagulation test measures the time required for thrombin to convert
fibrinogen to fibrin?
TT
Which coagulation test measures platelet number and function?
Bleeding time
What is caused by arterial thrombosis in the brain?
Stroke
What is caused by arterial thrombosis in the heart?
AMI
What is caused by arterial thrombosis in the limb?
Gangrene
How does plasmin activate complement?
Cleaves C3 into C3a and C3b
What is the name of C3a?
Anaphylatoxin
What is the name of C3b?
Opsonin
What does warfarin inhibit?
Vitamin K
What is a vitamin K dependent protease inhibitor that acts as a co-factor for
Protein C?
Protein S
What is a vitamin K dependent protease inhibitor that is activated by thrombin
and degrades factors V and VIII:C?
Protein C
Which protease inhibitor is the major natural inhibitor, also called heparin co-
factor because it is greatly accelerated by heparin, and is the major inactivator of
thrombin and Xa?
Antithrombin III (ATIII)
What is the main inhibitor of plasmin and inhibits rapidly?
,Alpha 2 antiplasmin
What is a plasmin inhibitor that inhibits slowly?
Alpha 2 macroglobulin
What enzyme is responsible for hydrolyzing fibrin, fibrinogen and other
coagulation proteins?
Plasmin
What system is activated when plasminogen that is bound to fibrin is converted
to plasmin by TPA?
Fibrinolytic system
What system results in enzymatic cleavage of the fibrin clot to soluble fragments
to re-establish blood flow?
Fibrinolytic system
What factors are involved in the common pathway?
I, II, V, X
Which coagulation tests can monitor the common pathway?
PT and APTT
Which pathway begins with the activation of factor X by the intrinsic and/or
extrinsic pathway?
Common
Which portion of factor VIII is the smallest portion, called the procoagulant
protein or anti-hemophilic portion, and acts as a co-factor for factor IXa to
activate factor X in the intrinsic pathway?
VIII:C
Which portion of factor VIII is the larger portion, called the carrier portion, and is
necessary for platelet adhesion to tissue?
VWF
Activation of which factor activates the intrinsic pathway, inflammation
(prekallikrein), fibrinolysis, and complement?
XII
Which factors are needed to amplify the contact factors to speed up the intrinsic
pathway?
Fletcher and Fitzgerald
Which factors are involved in the intrinsic pathway?
XII, XI, IX, VIII, Fletcher, Fitzgerald
Which factors are involved in the extrinsic pathway?
III, VII
High molecular weight proteins that are consumed during clotting and are acted
on by thrombin to convert fibrinogen to fibrin, includes factors I, V, VIII, and XIII
Fibrinogen proteins
Low molecular weight, vitamin K dependent proteins that contain the amino acids
necessary for Ca2+ binding, includes factors II, VII, IX, and X
Prothrombin proteins
Factors that in vitamin K deficiency will lack specific binding receptors for Ca2+
and therefore do not function normally, includes factors II, VII, IX, and X
PIVKAs (proteins induced by vitamin K absence)
, Proteins that are involved in the initial phase of intrinsic system activation,
includes factors XI, XII, Fletcher, and Fitzgerald?
Contact proteins
Which coagulation factors act as enzymes?
II, VII, IX, X, XI, XII, XIII
Which factors are proteases that cleave peptide bonds when activated?
II, VII, IX, X, XI, XII
Which factor is a transaminase that cross links fibrin monomers to give a stable
fibrin clot?
XIII
Which coagulation factors act as co-factors?
III, V, VIII:C, Fitzgerald
Factors that accelerate the reactions of enzyme coagulation factors
Co-factors
What coagulation factors act as substrates?
I
The type of factor that the enzymes act on
Substrate
Where is VWF produced?
Endothelial cells and megakaryocytes
Where are most of the coagulation factors produced?
Liver
A disorder of platelet secretion of ADP due to decreased stores of ADP/ATP in
dense granules, causing decreased aggregation
Storage pool deficiency
Which coagulation disorder is caused by decreased factor IX, has a normal PT,
bleeding time, and platelet count, but a prolonged APTT?
Hemophilia B
What is another name for Hemophilia B?
Christmas disease
Which coagulation disorder is caused by decreased factor VIII, has a normal PT,
bleeding time, and platelet count, but a prolonged APTT?
Hemophilia A
Which congenital platelet disorder is a disorder of platelet aggregation caused by
absence or deficiency of platelet receptors GIIb and GIIIa, therefore platelets
cannot bind fibrinogen, VWF, or fibronectin - bleeding time is increased, clot
retraction is absent, platelet morphology and function is normal?
Glanzmann's thrombasthenia
Which congenital platelet disorder is a rare disorder of adhesion caused by a
defect or lack of platelet receptor G1b, therefore platelets cannot bind to VWF on
endothelial cells - platelets are giant and poorly functioning, bleeding time is
increased, platelet count is decreased, clot retraction is normal?
Bernard Soulier
What is a treatment for VWD and sometimes Hemophilia A that induces release of
VWF from endothelial tissue?
DDVAP
