Samenvatting Oud-examenvragen Cellular Immunology -
Geert Raes
A 10 year old male patient is diagnosed with an acute bacterial infection. His blood
leukocyte count was 38,000 cells per uL (reference range: 4,500 - 12,500 per uL). The
predominant cell type found in increased numbers in this patient's blood is:
a. eosinophils
b. neutrophils
c. monocytes
d. B cells
e. dendritic cells - ANSWER---neutrophils
Cytotoxxic T cells are isolated from a sample of peripheral blood from a healthy 25 year
old female medical student participating in a research study. Which of the following
molecules will these cells express on their cell surfaces in addition to CD8?
a. CCL2
b. CD1d
c. CD3
d. CD4
e. CD19 - ANSWER---CD3
A previously healthy 17 year old male patient presents for evaluation of recent onset
severe pain in his knees and elbows. He is febrile and examination reveals a rash on
his trunk, arms, and legs. His past medical history is unremarkable, and he is up to date
on all immunizations. Further questioning reveals that he had a sore throat about 3
weeks ago that resolved without treatment. The signs and symptoms experienced now
by this patient are most likely the result of a/an
a. .allergic reaction
b. cell-mediated hypersensitivity
c. cytotoxic reaction
d. contact dermatitis
e. immune complex disease - ANSWER---immune complex disease
Antibodies directed against which of the following proteins are useful in identifying T
helper cells in samples of peripheral blood?
a. CCL21
b. CD4
c. CD56
d. CXCR4
e. LFA-1 - ANSWER---CD4
A 4 year old boy has a history of recurrent bacterial infections, including several
episodes of pneumococcal sepsis. He has an undetectable level of serum
immunoglobulins and is diagnosed with an X-linked disorder. The disorder most likely to
be responsible for the findings in this patient is
a. Bruton agammaglobulinemia
b. Chediak-Higashi syndrome
c. CVID
d. DiGeorge syndrome
, e. Hereditary angioedema - ANSWER---Bruton agammaglobulinemia
A 27 year old female presents for evaluation of fatigue, loss of appetite, and muscle
aches of several months duration. She also reports increased sensitivity to sunlight.
Testing reveals the presence of antinuclear antibodies. The HLA gene most likely
associated with her condition is
a. B8
b. B27
c. Cw6
d. DR3
e. DR4 - ANSWER---DR3
A 17 year old female patient has mounted a considerable adaptive immune response.
Which of the following most likely served as the trigger of this response?
a. Albumin (a protein) from her own blood plasma
b. Botulinum toxin from Clostridium botulinum
c. Ethinyl estradiol (an estrogenic steroid hormone) from her oral contraceptives
d. Fructose from high-fructose corn syrup
e. Glycine (an amino acid) from a mouse protein - ANSWER---Botulinum toxin from
Clostridium botulinum
A healthy 27 year old male participates in a research study. Cell isolated from his
peripheral blood express MHC Class II molecules. Which of the following types of cell
have been isolated?
a. B cells
b. Eosinophils
c. Erythrocytes
d. Granulocytes
e. Natural killer cells - ANSWER---B cells
A certain population of lymphocytes inhibits activity of autoreactive lymphocytes. Such
inhibitory cells express both
a. CD4 and CD25
b. CD19 and CD45
c. CD28 and CD80
d. IgA and IgD
e. IgG and IgM - ANSWER---CD4 and CD25
"regulatory T cells"
A previously healthy 9 year old girl becomes infected with a strain of Strep. pyogenes
that she has not encountered in the past. She does not want to miss a birthday party,
does not complain of a sore throat, and does not receive medical treatment. Two weeks
later, her symptoms have resolved and microbial numbers have decreased rapidly. The
isotype of antibody responsible for eventual clearing of this infection is
a. IgA
b. IgD
c. IgE
d. IgG
e. IgM - ANSWER---IgG
A large amount of a certain immunoglobulin isotype is found associated with the
mucosal surface of the GI tract. This immunoglobulin isotype is most likely
Geert Raes
A 10 year old male patient is diagnosed with an acute bacterial infection. His blood
leukocyte count was 38,000 cells per uL (reference range: 4,500 - 12,500 per uL). The
predominant cell type found in increased numbers in this patient's blood is:
a. eosinophils
b. neutrophils
c. monocytes
d. B cells
e. dendritic cells - ANSWER---neutrophils
Cytotoxxic T cells are isolated from a sample of peripheral blood from a healthy 25 year
old female medical student participating in a research study. Which of the following
molecules will these cells express on their cell surfaces in addition to CD8?
a. CCL2
b. CD1d
c. CD3
d. CD4
e. CD19 - ANSWER---CD3
A previously healthy 17 year old male patient presents for evaluation of recent onset
severe pain in his knees and elbows. He is febrile and examination reveals a rash on
his trunk, arms, and legs. His past medical history is unremarkable, and he is up to date
on all immunizations. Further questioning reveals that he had a sore throat about 3
weeks ago that resolved without treatment. The signs and symptoms experienced now
by this patient are most likely the result of a/an
a. .allergic reaction
b. cell-mediated hypersensitivity
c. cytotoxic reaction
d. contact dermatitis
e. immune complex disease - ANSWER---immune complex disease
Antibodies directed against which of the following proteins are useful in identifying T
helper cells in samples of peripheral blood?
a. CCL21
b. CD4
c. CD56
d. CXCR4
e. LFA-1 - ANSWER---CD4
A 4 year old boy has a history of recurrent bacterial infections, including several
episodes of pneumococcal sepsis. He has an undetectable level of serum
immunoglobulins and is diagnosed with an X-linked disorder. The disorder most likely to
be responsible for the findings in this patient is
a. Bruton agammaglobulinemia
b. Chediak-Higashi syndrome
c. CVID
d. DiGeorge syndrome
, e. Hereditary angioedema - ANSWER---Bruton agammaglobulinemia
A 27 year old female presents for evaluation of fatigue, loss of appetite, and muscle
aches of several months duration. She also reports increased sensitivity to sunlight.
Testing reveals the presence of antinuclear antibodies. The HLA gene most likely
associated with her condition is
a. B8
b. B27
c. Cw6
d. DR3
e. DR4 - ANSWER---DR3
A 17 year old female patient has mounted a considerable adaptive immune response.
Which of the following most likely served as the trigger of this response?
a. Albumin (a protein) from her own blood plasma
b. Botulinum toxin from Clostridium botulinum
c. Ethinyl estradiol (an estrogenic steroid hormone) from her oral contraceptives
d. Fructose from high-fructose corn syrup
e. Glycine (an amino acid) from a mouse protein - ANSWER---Botulinum toxin from
Clostridium botulinum
A healthy 27 year old male participates in a research study. Cell isolated from his
peripheral blood express MHC Class II molecules. Which of the following types of cell
have been isolated?
a. B cells
b. Eosinophils
c. Erythrocytes
d. Granulocytes
e. Natural killer cells - ANSWER---B cells
A certain population of lymphocytes inhibits activity of autoreactive lymphocytes. Such
inhibitory cells express both
a. CD4 and CD25
b. CD19 and CD45
c. CD28 and CD80
d. IgA and IgD
e. IgG and IgM - ANSWER---CD4 and CD25
"regulatory T cells"
A previously healthy 9 year old girl becomes infected with a strain of Strep. pyogenes
that she has not encountered in the past. She does not want to miss a birthday party,
does not complain of a sore throat, and does not receive medical treatment. Two weeks
later, her symptoms have resolved and microbial numbers have decreased rapidly. The
isotype of antibody responsible for eventual clearing of this infection is
a. IgA
b. IgD
c. IgE
d. IgG
e. IgM - ANSWER---IgG
A large amount of a certain immunoglobulin isotype is found associated with the
mucosal surface of the GI tract. This immunoglobulin isotype is most likely
