TEST BANK FOR PSYCHOPHARMACOLOGY DRUGS THE BRAIN AND BEHAVIOR 3RD EDITION BY MEYER.

TEST BANK FORPSYCHOPHARMACOLOGY DRUGS TH
BRAIN AND BEHAVIOR 3RD EDITION BY MEYER.
Chapter 1: Principles of Pharmacology

Multiple Choice

• refer(s) to specific molecular changes that occur when a drug binds to a
particular target site or receptor, while are the resulting widespread alterations in
function.
• Drug action; therapeutic effects
• Side effects; drug effects
• Therapeutic effects; side effects
• Drug action; drug effects
Answer: d
Textbook Reference: Pharmacology: The Science of Drug Action

• After drug administration has occurred, the amount of drug in the blood that is free to
bind at specific target sites is referred to as
• the therapeutic dose.
• first-pass effects.
• bioavailability.
• ED50.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• The specific molecular changes that occur when a drug binds to a particular target siteor
receptor are referred to as
• drug effects.
• drug action.
• side effects.
• placebo effects.
Answer: b
Textbook Reference: Pharmacology: The Science of Drug Action

• Which of the following is not a possible explanation for placebo effects?
• Pavlovian conditioning
• Genetic variation
• Drug competition
• Expectation of outcome
Answer: c
Textbook Reference: Pharmacology: The Science of Drug Action

,• The administration of oxytocin has been proposed as a treatment for autism.
• intravenous
• oral
• intranasal
• intracerebral
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Which factor does not affect the pharmacokinetics of a drug?
• Route of administration
• Lipid solubility
• Depot binding
• Drug action
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• First-pass metabolism occurs when drugs are taken
• orally.
• intravenously.
• subcutaneously.
• nasally.
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• The area postrema is one area in the brain where the is not complete.
• cerebrospinal fluid
• blood–brain barrier
• choroid plexus
• phospholipid membrane
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• First-pass metabolism occurs with orally administered drugs because
• their absorption is slowed by food.
• drugs absorbed into the bloodstream from the stomach go to the liver on the way to
general circulation.
• drugs must first survive the acidic environment of the stomach.
• salivary enzymes in the mouth begin the process of metabolism.
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

,• Toxic substances in the blood trigger a vomiting response by activating the
• blood–brain barrier.
• choroid plexus.
• area postrema.
• median eminence.

Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Drugs administered _ have the most rapid onset of action.
• subcutaneously
• intramuscularly
• orally
• intravenously
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Ionization of a drug depends on the of the solution and the of the
drug.
• pH; pKa
• pKa; pH
• concentration; lipid solubility
• pH; concentration
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• The absorption of a drug depends on all of the following except
• lipid solubility.
• ionization.
• body temperature.
• the concentration of the drug.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Drugs that are should be avoided by women of childbearing age.
• teratogenic
• able to cross the placental barrier
• psychoactive
• highly lipid-soluble
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

, • Agents that induce developmental abnormalities in a fetus are known as
• psychoactive drugs.
• illicit drugs.
• teratogens.
• placental drugs.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Depot binding is said to occur when drugs
• bind to their target sites.

• bind to inactive sites.
• compete for binding sites.
• are excreted before binding.
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Which statement about depot binding is false?
• It reduces the concentration of drug at its site of action.
• It may delay the onset of drug action.
• It may prolong drug action by disrupting normal metabolism.
• It increases the concentration of drug at its site of action by releasing large quantities at
once.
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Drug metabolism mostly occurs in the and usually makes a drug more
soluble.
• kidneys; fat
• liver; fat
• liver; water
• kidneys; water
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action

• Which statement about drug clearance by first-order kinetics is false?
• Molecules of a drug are cleared at a constant rate regardless of drug concentration.
• Molecules of a drug are cleared at an exponential rate.
• A constant fraction of the free drug in the blood is removed in each time interval.
• Clearance of most drugs occurs in this manner.
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action