WITH ANSWERS
Carbapenems
Patients using valproate to control seizures should not be placed on imipenem.
Vancomycin
Use with caution in patients with renal impairment.
Cephalosporins
Contraindicated for patients with a history of allergic reactions to this drug class or severe reactions to
penicillin.
Tetracyclines
Contraindicated ind with s pregnant women and in children younger than 8 years.
Macrolides
Use with caution in patients with QT prolongation.
Aminoglycosides
Used with caution in patients with renal impairment, preexisting hearing impairment, and those
receiving cytotoxic and neurotoxic drugs
Trimethoprim/Sulfam
,Contraindicated for nursing mothers, pregnant women in the first trimester and also those near term,
and infants younger than 2 months.
Penicillin High Risk for Toxicity
Renal Impairment
Acutely ill
Very young
Very Old
Which patients should penicillins be used with extreme caution?
Patients with a history of severe allergic reactions to cephalosporins, or carbapenems.
Cephalosporins
All appear to be safe for use in pregnancy
Penicillins
Although there are no well-controlled studies in pregnant women, evidence we do have suggests there
is no second or third trimester fetal risk.
Tetracyclines
Animal studies reveal that these drugs can cause fetal harm in pregnancy. Thus this class of drugs should
be avoided in during pregnancy.
Aminoglycosides
, There is evidence that use of this drug class in pregnancy can harm the fetus so they should not be used.
Sulfonamides
Systemic drugs in this class may cause birth defects, especially if taken during the first semester. If taken
near term, the infant may develop kernicterus.
Acute otitis externa presents with what symptoms that differentiates it from otitis media to determine
diagnosis and treatment?
Rapid-onset ear pain that include pruritis.
What baseline data is needed to prescribe trimethoprim/sulfamethoxazole? (Select all that apply)
2 Establish an infection appropriate for this drug class exists Complete blood count with white cell
differential for prolonged therapy Renal function if there is concern in may be compromised
Which antibiotic class is most likely to be given to someone with otitis media if there are no
contraindications?
Penicillin After 3 days of observation, start 10 days of amoxicillin or amoxicillin/clavulanate. Information
found in the course module.
What is the likely causative agent for acute otitis media?
Streptococcus pneumoniae
Third-generation drugs Cephalosporins are used to treat bacterial infections in neonates as well as
infants.
Cephalosporins